Glistening formation in a new hydrophobic acrylic intraocular lens

Abstract Background: The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well-established in-vitro laboratory method, we evaluated a new IOL material’s resistance to glistening formation. Methods: An in-vitro stress test for glistening induction was performed on twenty samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm 2 ) was evaluated in five sections of each IOL. The results for each model were compared and rated on the Miyata Scale for grading glistening severity. Results: In all cases, glistening number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm 2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm². The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm². Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero. Conclusion: In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. Results from this in-vitro study suggest that glistening numbers will be low in clinical use in the Eyecryl ASHFY600.

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Glistening formation in a new hydrophobic acrylic intraocular lens

10.21203/rs.2.16427/v3 ◽

2020 ◽

Author(s):

Timur M. Yildirim ◽

Hui Fang ◽

Sonja K. Schickhardt ◽

Qiang Wang ◽

Patrick R. Merz ◽

...

Keyword(s):

Stress Test ◽

In Vitro Study ◽

Mean Value ◽

Laboratory Method ◽

Intraocular Lenses ◽

Fort Worth ◽

In Vitro Stress ◽

Vision Care ◽

Hydrophobic Acrylic

Abstract Background: The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well-established in-vitro laboratory method, we evaluated a new IOL material’s resistance to glistening formation.Methods: An in-vitro stress test for glistening induction was performed on twenty samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm2) was evaluated in five sections of each IOL. The results for each model were compared and rated on the Miyata Scale for grading glistening severity.Results: In all cases, glistening number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm². The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm². Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero.Conclusion: In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. Results from this in-vitro study suggest that glistening numbers will be low in clinical use in the Eyecryl ASHFY600.

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The material quality of a new hydrophobic acrylic intraocular lens

10.21203/rs.2.16427/v1 ◽

2019 ◽

Author(s):

Timur M. Yildirim ◽

Hui Fang ◽

Sonja K. Schickhardt ◽

Qiang Wang ◽

Patrick R. Merz ◽

...

Keyword(s):

Stress Test ◽

Mean Value ◽

Laboratory Method ◽

Intraocular Lenses ◽

Fort Worth ◽

In Vitro Stress ◽

Vision Care ◽

Hydrophobic Acrylic

Abstract Background The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well established in-vitro laboratory method, we evaluated a new IOL material’s resistance to glistenings formation. Methods An in-vitro stress test for glistenings induction was performed on twenty samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm 2 ) was evaluated in five sections of each IOL. The results for each model were compared and rated on the Miyata Scale for grading glistening severity. Results In all cases, glistenings number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm 2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm 2 . The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm 2 . Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero. Conclusion In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. In clinical use, one can confidently expect glistenings numbers will be low and clinically irrelevant in the Eyecryl ASHFY600.

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In-vitro glistening formation in six different foldable hydrophobic intraocular lenses

BMC Ophthalmology ◽

10.1186/s12886-021-01879-6 ◽

2021 ◽

Vol 21 (1) ◽

Cited By ~ 2

Author(s):

Tamer Tandogan ◽

Gerd U. Auffarth ◽

Hyeck-Soo Son ◽

Patrick Merz ◽

Chul Young Choi ◽

...

Keyword(s):

Image Analysis ◽

Laboratory Method ◽

Intraocular Lenses ◽

Analysis Program ◽

Quality Of Vision ◽

Different Types ◽

The Mean ◽

Hydrophobic Acrylic

Abstract Background Glistenings describe small, refractile microvacuoles that may arise within the intraocular lens (IOL) material and reduce the patients’ quality of vision. Lenses composed of hydrophobic acrylic material are particularly affected by glistening formation. In this study, we compared the tendency of glistening formation in six different types of hydrophobic acrylic intraocular lenses (IOLs). Methods We used a well-established accelerated laboratory method to develop glistenings in the following IOLs: Vivinex XY1 (Hoya), AcrySof SN60WF (Alcon), Tecnis ZCB00 (AMO), Avansee PN6A (Kowa), Aktis SP NS-60YG (Nidek), and CT Lucia 601P (Zeiss). IOLs were first immersed in saline at 45 °C for 24 h and then at 37 °C for 2.5 h in a water bath. Microvacuole (MV) density and size (Miyata grading) were documented and calculated using an image analysis program. Results The mean glistening density [MV/mm2] and mean Miyata grading (in brackets) were: Vivinex: 11.6 ± 5.7 (0), SN60WF: 264.4 ± 110.3 (2.6), Tecnis: 6.0 ± 2.8 (0), Avansee: 2.2 ± 0.7 (0), Aktis: 851.4 ± 59.4 (3+) and CT Lucia: 71.0 ± 71.6 (1). Conclusions While all tested IOLs showed glistenings with the accelerated laboratory method, the Aktis and SN60WF showed the highest microvacuole density, followed by the CT Lucia. In comparison, the Vivinex, Tecnis, and Avansee IOLs showed far fewer number of glistenings.

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Comparative analysis of in vitro accelerated glistening formation in foldable hydrophobic intraocular lenses

International Ophthalmology ◽

10.1007/s10792-021-01870-6 ◽

2021 ◽

Author(s):

Tamer Tandogan ◽

Gerd U. Auffarth ◽

Chul Young Choi ◽

Hyeck-Soo Son ◽

Ramin Khoramnia

Keyword(s):

Image Analysis ◽

Comparative Analysis ◽

Clinical Results ◽

Laboratory Method ◽

High Density ◽

Intraocular Lenses ◽

Analysis Program ◽

Different Types ◽

Hydrophobic Acrylic

Abstract Purpose To analyse and compare the propensity to form glistenings in 4 different types of hydrophobic acrylic intraocular lenses (IOLs): Alcon AcrySof ® MA60AC, HOYA iSert® PC-60AD, Bausch&Lomb enVista, and Kowa Avansee™ PU6A. Methods We used an accelerated laboratory method to create glistenings. IOLs were first immersed in saline at 45 °C for 24 h and then at 37 °C for 2.5 h. Microvacuole (MV) density and size were documented and calculated using an image analysis program. Results Median density of glistenings [MV/mm2] for Alcon AcrySof ® MA60AC was 623 (range 507–804), for HOYA iSert® PC-60AD 1358 (range 684–2699), for Bausch&Lomb enVista 2 (range 1–2), and for Kowa Avansee™ PU6A 1 (range 1–4). The prevailing MV size was: 0–5 µm for Hoya IOLs, 5–10 µm for Alcon IOLs, 20–50 µm for Bausch&Lomb IOLs, and 5–50 µm for Kowa IOLs. Conclusions Glistenings could be induced in all studied IOLs using the accelerated laboratory method. The Alcon AcrySof ® MA60AC and HOYA iSert® PC-60AD IOLs showed MV of high density, while the glistenings in the Hoya IOLs were smaller in size compared to the Alcon IOLs. The MV density was minimal in the Bausch&Lomb enVista and Kowa Avansee™ PU6A IOLs. The propensity of the Alcon AcrySof ® MA60AC IOLs to form glistenings in vitro correlated with the findings of clinical results that are already published.

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Quantitative evaluation of microvacuole formation in five intraocular lens models made of different hydrophobic materials

PLoS ONE ◽

10.1371/journal.pone.0250860 ◽

2021 ◽

Vol 16 (4) ◽

pp. e0250860

Author(s):

Timur M. Yildirim ◽

Sonja K. Schickhardt ◽

Qiang Wang ◽

Elfriede Friedmann ◽

Ramin Khoramnia ◽

...

Keyword(s):

Intraocular Lenses ◽

Laboratory Model ◽

Copolymer Composition ◽

Fort Worth ◽

Clinical Use ◽

Acrylic Copolymer ◽

Santa Ana ◽

Hydrophobic Materials ◽

Hydrophobic Acrylic

In this laboratory study, we assessed the resistance to microvacuole (glistening) formation in hydrophobic intraocular lenses (IOLs). Glistenings were induced in five lenses each of five different hydrophobic acrylic IOL models, using an established in vitro laboratory model: 800C (Rayner, Worthing, UK), AcrySof SN60WF (Alcon, Fort Worth, USA), Tecnis ZCB00 (Johnson & Johnson Vision, Santa Ana, USA), Vivinex XY1 (Hoya, Tokyo, Japan) and CT Lucia 611P (Zeiss, Oberkochen, Germany). We evaluated the number of microvacuoles per square millimeter (MV/mm2) in the central part of each IOL. Results were analyzed statistically, and mean glistening numbers were ranked, with the highest in the SN60WF which had 66.0 (±45.5) MVs/mm, followed by the 611P with 30.7 (±8.4) MVs/mm2. The 800C and XY1 showed comparable values of 2.0 (±3.6) and 2.7 (±2.4) MVs/mm2, respectively. ZCB00 had the lowest number with 0.9 (±0.6) MVs/mm2. This study shows that the resistance to glistening formation differs depending on the hydrophobic acrylic copolymer composition of the IOL material. Some IOLs from current clinical use are still prone to develop glistenings whereas others, including the ZCB00, 800C and XY1 show high resistance to microvacuole formation.

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Shear bond strength evaluation of bonded molar tubes on fluorotic molars

The Angle Orthodontist ◽

10.2319/030812-203.1 ◽

2012 ◽

Vol 83 (1) ◽

pp. 152-157 ◽

Cited By ~ 6

Author(s):

Erika L. Silva-Benítez ◽

Veronica Zavala-Alonso ◽

Gabriel A. Martinez-Castanon ◽

Juan P. Loyola-Rodriguez ◽

Nuria Patiño-Marin ◽

...

Keyword(s):

Bond Strength ◽

Shear Bond Strength ◽

Dental Fluorosis ◽

In Vitro Study ◽

Mean Value ◽

Fixed Appliance ◽

Adhesive Remnant Index ◽

The Mean ◽

Electronic Microscope

Abstract Objective: To study the shear bond strength (SBS), sites of failure, and micromorphology of bonded molar tubes used on teeth affected by dental fluorosis. Materials and Methods: This in vitro study included 140 first molars classified according to Dean's index for dental fluorosis. Samples were divided into seven groups: (1) healthy teeth etched for 15 seconds, (2) teeth with moderate fluorosis (MOF) etched for 15 seconds, (3) teeth with MOF etched for 150 seconds, (4) teeth with MOF microabrasion etched for 15 seconds, (5) teeth with severe fluorosis (SEF) etched for 15 seconds, (6) teeth with SEF etched for 150 seconds, and (7) teeth with SEF microabrasion etched for 15 seconds. All samples were incubated and were then submitted to the SBS test and evaluated with the modified adhesive remnant index (ARI) and analyzed by using a scanning electronic microscope. Results: The SBS mean value for healthy enamel was 20 ± 10.2 MPa. For the group with MOF, the etched 150-second mean value was the highest (19 ± 7.6 MPa); for the group with SEF treated with microabrasion and etched for 15 seconds, the mean value was (13 ± 4.1 MPa). Significant differences (P ≤ .05) were found in the ARI between healthy and fluorosed groups. Conclusions: Fluorotic enamel affects the adhesion of bonded molar tubes. The use of overetching in cases of MOF and the combination of microabrasion and etching in SEF provides a suitable adhesion for fixed appliance therapy.

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In-Vitro Study of Bacterial Adherence to Different Types of Intraocular Lenses

Drug Development and Industrial Pharmacy ◽

10.1081/ddc-120001490 ◽

2002 ◽

Vol 28 (1) ◽

pp. 95-99 ◽

Cited By ~ 20

Author(s):

Carole Burillon ◽

Laurent Kodjikian ◽

Gérard Pellon ◽

Annie Martra ◽

Jean Freney ◽

...

Keyword(s):

In Vitro Study ◽

Bacterial Adherence ◽

Vitro Study ◽

Intraocular Lenses ◽

Different Types

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Milled versus moulded mock-ups based on the superimposition of 3D meshes from digital oral impressions: a comparative in vitro study in the aesthetic area

BMC Oral Health ◽

10.1186/s12903-019-0922-2 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 14

Author(s):

Francesca Cattoni ◽

Giulia Teté ◽

Alessandro Mauro Calloni ◽

Fabio Manazza ◽

Giorgio Gastaldi ◽

...

Keyword(s):

Statistical Analysis ◽

Test Group ◽

In Vitro Study ◽

Mean Value ◽

Digital Impression ◽

Control Group ◽

Minimal Invasiveness ◽

Significant Difference ◽

The Aesthetic

Abstract Background Aesthetic porcelain veneers proved to be a long-term reliable prosthetic solution, ensuring minimal invasiveness. The use of veneers requires an adhesive cementation technique, so maintaining as much enamel as possible is to ensure lasting success. A diagnostic mock-up is a key tool that allows a preview of the outcome of the aesthetic restoration: it is obtainable both in an analog and digital way. With the recent developments in impression technology and the ever so fast growing use of CAD-CAM technologies it is useful to understand the pros and cons of either one of these techniques (analog and digital) in order to identify the easier and more convenient workflow in aesthetic dentistry. Methods After taking pictures and impressions of the dental arcs of a patient in need of aesthetic rehabilitation, 52 resin models were produced and a digital drawing of the smile was outlined. Both an analog and a digital wax-up were obtained from two of the 52 models: the latter was obtained using digital impressions and a dedicated software. The analog wax-up was then used to produce 25 matrices that have later been used to mould 25 resin mock-ups using a traditional moulding protocol (Control Group - CG). The digital wax-up was used to mill 25 PMMA mock-ups. Each mock-up, both milled and moulded (total 50), was then laid on the other 50 resin models as a digital impression of it was taken. The STL. files of the milled mock-ups were compared with the 3D CAD wax-up made using a specific software. The STL. files of the analog printed mock-ups were compared with the traditional wax-up design. A statistical analysis was carried out to evaluate the difference between the groups. Results The statistical analysis showed a significant difference (P > 0.01) between the mean value of the distance between the points of the overlapping STL. meshes in GC (0.0468 mm) and in TG (Test Group - TG) (0,0109 mm). Conclusions The study showed a difference in accuracy between traditional moulded and milled mock-ups compared to their original wax-up. The data analysis reports that the digital method allows for greater accuracy. Within the limitations of this study, a fully digital workflow is to considered more reliable when it come to creating an esthetic mockup: the digital procedure has been shown to be more accurate than the one made manually which is much more operator dependent and it brings an increase to the chance of error, and that could ultimately affect the final result.

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