scholarly journals Correlation between IL‐7R gene variants and breast cancer susceptibility in Chinese Han women

2020 ◽  
Author(s):  
Miao Li ◽  
Chenli Yue ◽  
Xiaoxiao Zuo ◽  
Guoquan Jin ◽  
Guanying Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Size ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Gene Variants ◽  
Tumor Site ◽  
Healthy Individuals ◽  
Chinese Han ◽  
Stratified Analysis ◽  
Er Expression

Abstract Introduction IL-7R is involved in the occurrence and development of breast cancer by binding to its ligand IL-7. This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibility in Chinese Han women.Methods Five polymorphisms (rs969129, rs10213865, rs10053847, rs118137916, and rs6451231) of IL-7R genewere genotyped in 553 patients and 550 healthy healthy individuals from the in Chinese Han women using the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated used to evaluate the relationship.Results IL-7R rs10213865, rs969129 and rs6451231 was correlated with an increased the risk of breast cancer in multiple genetic models. Age stratified analysis revealed that rs6451231 was correlated with an increased breast cancer risk at age > 52 years. Additionally, rs10213865 was correlated with tumor site and ER expression, rs969129 was related to tumor size and Ki67 expresses status, and rs6451231was related to tumor size. Haplotype CGAG (rs969129, rs10213865, rs10053847 and rs118137916) were observed to a decrease breast cancer risk.Conclusions IL-7R polymorphism were significantly correlated with an increased breast cancer susceptibility in Chinese Han women.

IL-7R gene variants are associated with breast cancer susceptibility in Chinese Han women

2020 ◽  
Vol 86 ◽  
pp. 106756
Author(s):  
Zhenghua Wang ◽  
Xiaoyu Wang ◽  
Yu Gao ◽  
Yuanyuan Wang ◽  
Minghao Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Gene Variants ◽  
Chinese Han

Evaluation of Association of LOC105371267 Polymorphisms and Breast Cancer Susceptibility

2020 ◽  
Author(s):  
Xiaoli Liu ◽  
Dandan Li ◽  
Chunjuan He ◽  
Linna Peng ◽  
Shishi Xing ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Haplotype Analysis ◽  
Genetic Model ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Candidate Snps ◽  
Healthy Individuals ◽  
Stratified Analysis ◽  
Relationship Of ◽  
The Relationship

Abstract Background: LOC105371267 (also known as PR-lncRNA1) was reported to be a p53-regulated lncRNA, which played essential roles in the pathogenesis of breast cancer (BC). We aimed to investigate the potential associations between LOC105371267 polymorphisms and BC risk. Method: Totally, 555 healthy individuals and 561 BC patients were recruited. Five candidate SNPs of LOC105371267 were genotyped with Agena MassARRAY system. Odds ratio (OR) and 95% confidence intervals (CIs) were applied to evaluate the relationship of LOC105371267 with BC susceptibility. Additionally, stratification analyses based on clinical features and haplotype analysis were also conducted. Results: A decreased BC risk was observed rs3931698 GG genotype (OR = 0.30, P = 0.018) and recessive genetic model (OR = 0.30, P = 0.021). Stratified analysis with age also revealed that this SNP was associated with a lower risk at age < 52 years. Meanwhile, multiple clinical characteristics, including ER and PR status and stage were all correlated with SNPs rs6499221, rs3931698, rs3852740 and rs8044565.Conclusion: Four LOC105371267 SNPs (rs6499221, rs3931698, rs8044565 and rs3852740) were found to be correlated with development of BC. Additionally, ER, PR, and stage were also linked to LOC105371267 polymorphisms, providing novel diagnostic and therapeutic targets for of BC management.

CYP2D6 Gene Variants and Their Association with Breast Cancer Susceptibility

2011 ◽  
Vol 20 (6) ◽  
pp. 1255-1258 ◽  
Author(s):  
Jean E. Abraham ◽  
Mel J. Maranian ◽  
Kristy E. Driver ◽  
Radka Platte ◽  
Bolot Kalmyrzaev ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Gene Variants ◽  
Cyp2d6 Gene

Lysyl Oxidase 473 G>A Polymorphism and Breast Cancer Susceptibility in Chinese Han Population

2011 ◽  
Vol 30 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Jinghua Ren ◽  
Xiaoling Wu ◽  
Wenshan He ◽  
Jun Shao ◽  
Bo Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Susceptibility ◽  
Lysyl Oxidase ◽  
Breast Cancer Susceptibility ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Association of Genetic Polymorphisms in CDH1 and CTNNB1 with Breast Cancer Susceptibility and Patients' Prognosis among Chinese Han Women

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135865 ◽  
Author(s):  
Yu-Mian Jia ◽  
Yun-Tao Xie ◽  
Ya-Jun Wang ◽  
Ji-Yuan Han ◽  
Xin-Xia Tian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphisms ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Chinese Han

scholarly journals LRRC3B polymorphisms contributed to breast cancer susceptibility in Chinese Han Population

2020 ◽  
Author(s):  
Tianbo Jin ◽  
Linna Peng ◽  
Shishi Xing ◽  
Dandan Li ◽  
Chunjuan He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Poor Prognosis ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Suppressor Gene ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Single Nucleotide ◽  
Increased Risk ◽  
The Status

Abstract Purpose LRRC3B gene, as a tumor suppressor gene was involved in the development and progress of breast cancer (BC). However, the effect of LRRC3B polymorphisms on BC has rarely been reported. In the study, we aims to evaluate the relation between LRRC3B variants and BC risk. Methods Among 563 BC patients and 552 healthy controls, ten single-nucleotide polymorphisms (SNPs) in LRRC3B were genotyped by Agena MassARRAY. Odds ratios (OR) and 95% confidence interval (CI) was calculate using logistic regression model. Results Our study demonstrated that rs1907168 polymorphism (OR = 0.71, p = 0.017) reduced the risk of BC in the overall. In stratified analyses by age, rs1907168 decreased (OR = 0.53, p = 0.002) while rs78205284 (OR = 2.83, p = 0.034) increased BC susceptibility among the population at age ≤ 51 years. Clinical parameters such as tumor size, the status of PR and Ki67 were associated with LRRC3B variants. Furthermore, we found that the association of ‘GATT’ haplotype with an increased risk for BC. In addition, LRRC3B gene was down-regulated in BC tumor and had a poor prognosis in BC in silico analysis. Conclusion Our study firstly found LRRC3B SNPs contributed to the risk of BC, suggesting LRRC3B variants might help to predict BC progression.

Association Between miR-146a rs2910164 Polymorphism and Breast Cancer Susceptibility: An Updated Meta-analysis of 9545 Cases and 10030 Controls

MicroRNA ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Abdolkarim Moazeni-Roodi ◽  
Sajjad Aftabi ◽  
Sahel Sarabandi ◽  
Shima Karami ◽  
Mohammad Hashemi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Web Of Science ◽  
Genetic Model ◽  
Cancer Susceptibility ◽  
Quantitative Estimation ◽  
Meta Analysis ◽  
Breast Cancer Susceptibility ◽  
Precise Estimation ◽  
Potential Link ◽  
Stratified Analysis

Background: Several studies have reported a possible association of the miR-146a rs2910164 polymorphism with Breast Cancer (BC) development. However, the correlation between this polymorphism and susceptibility to BC is under debate. The current meta-analysis was designed and performed to more conclusively evaluate the miR-146a rs2910164 polymorphism and its potential link to BC. Methods: Our team has selected eligible studies (published up to October 2, 2020) from several electronic databases, including Web of Science, PubMed, Scopus and Google Scholar. A total number of 9,545 BC cases and 10,030 controls extracted from 26 eligible articles were included in this study. We utilized pooled Odds Ratios (ORs) as well as 95% confidence intervals (95% CIs) under five genetic models for quantitative estimation of any possible association between miR-146a rs2910164 polymorphism and BC. Results: Based on this meta-analysis, our findings suggest that there is no significant association between miR-146a rs2910164 polymorphism and BC risk. However, stratified analysis revealed that the rs2910164 polymorphism significantly increased the risk of BC in hospital-based studies using the homozygous genetic model (OR=1.37, 95%CI=1.01-1.86, p=0.043, CC vs. GG). Neither Asian nor Caucasian populations showed any significant association between rs2910164 polymorphism and BC susceptibility. Conclusion: In summary, our findings suggest that BC development is not associated with miR-146a rs2910164 polymorphism. However, larger ingenious future investigations might be needed for a more precise estimation of any association between miR-146a rs2910164 polymorphism and BC.

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