scholarly journals Using electroacupuncture to recover muscle strength in knee osteoarthritic patients after total knee arthroplasty: a study protocol for a double-blinded, randomized and placebo-controlled trial

2020 ◽  
Author(s):  
Hui Xu ◽  
Bingxin Kang ◽  
Yulin Li ◽  
Jun Xie ◽  
Songtao Sun ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Muscle Strength ◽  
Lower Extremity ◽  
Knee Arthroplasty ◽  
Rating Scale ◽  
Controlled Trial ◽  
Control Group ◽  
Acupuncture Points ◽  
Total Knee ◽  
Double Blinded

Abstract Background: Total knee arthroplasty (TKA) has recently become an almost irreplaceable and effective means to relieve pain, reconstruct knee motor function and improve the quality of life of patients with end-stage knee osteoarthritis (KOA). However, the muscle strength after TKA is usually difficult to recover. Although electroacupuncture (EA) can enhance the muscle strength of lower extremity, there is hardly any literature on the effect of EA on the muscle strength of lower extremity in patients after TKA. To address this problem, this trial is intended to evaluate the efficacy of EA after TKA for recovering the muscle strength of lower extremity, esp. in the early post-TKA period.Methods/design: This is a double-blinded, randomized and controlled trial. It will be conducted between January, 2020 and June, 2020. A total of 94 participants with KOA will have undergone unilateral TKA and they will then be randomized into a treatment group and a control group, viz. the EA group and the sham EA group. The former will receive EA at acupuncture points of ST37, ST36, SP10 and SP9. The latter, the control group will receive sham EA at sham locations for the acupuncture points of ST37, ST36, SP10 and SP9. The participants will be given 5 sessions of treatment per day for 2 weeks. The primary outcomes include a change in the amount of muscle strength and the Hospital for Special Surgery (HSS) score at the second week from a baseline (POD 3). The secondary outcomes include a 6-minute walking test, Numerical rating scale (NRS), the Hamilton Anxiety Scale and additional use of analgesia. The additional outcomes include incidence of analgesia-related side effects and rate of participant satisfaction. Blinding of the participants will also be assessed. The participants will be asked to guess whether they have received EA after the latest intervention. Adverse events of EA will be documented and assessed throughout the trial.Discussion: EA is helpful for the recovery and enhancement of muscle strength of the lower limb after TKA.

scholarly journals Role of Parecoxib Sodium in the Multimodal Analgesia after Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial

2018 ◽  
Vol 10 (4) ◽  
pp. 321-327 ◽  
Author(s):  
Yan-yan Bian ◽  
Long-chao Wang ◽  
Wen-wei Qian ◽  
Jin Lin ◽  
Jin Jin ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Controlled Trial ◽  
Multimodal Analgesia ◽  
Total Knee ◽  
Double Blinded

Peri-articular Steroid Injection in Total Knee Arthroplasty: A Prospective, Double Blinded, Randomized Controlled Trial

2013 ◽  
Vol 28 (4) ◽  
pp. 620-623 ◽  
Author(s):  
Samuel K. Chia ◽  
Gregory C. Wernecke ◽  
Ian A. Harris ◽  
Martin T. Bohm ◽  
Darren B. Chen ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Randomized Controlled Trial ◽  
Knee Arthroplasty ◽  
Steroid Injection ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Total Knee ◽  
Double Blinded

scholarly journals Local Efficacy of Corticosteroids as an Adjuvant for Periarticular Cocktail Injection in Simultaneous Bilateral Total Knee Arthroplasty: A Prospective Randomized Double-blind Controlled Trial

2020 ◽  
Author(s):  
huiming peng ◽  
wei wang ◽  
jin lin ◽  
xisheng weng ◽  
wenwei qian ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Visual Analog Scale ◽  
Knee Arthroplasty ◽  
Controlled Trial ◽  
Visual Analog Scale Score ◽  
Analog Scale ◽  
Double Blind ◽  
Total Knee ◽  
Double Blinded ◽  
Hss Score

Abstract Background: Multimodal cocktail periarticular injection(MCPI) including corticosteroids is currently widely applied to reduce postoperative pain and swelling following total knee arthroplasty (TKA). However the addition of steroids is controversial.This prospective, double-blinded, randomized, controlled trial compares the safety and efficacy of MCPI with or without corticosteroids.Methods: A total of 60 patients (120 knees) who underwent simultaneous bilateral TKAs received periarticular injections with added betamethasone (7mg) in a randomly selected knee, and the other knee was injected without added corticosteroids. The visual analog scale(VAS) pain scores at rest and in motion, range of motion (ROM), thigh swelling, hospital for special surgery(HSS) score, and adverse events were compared between the 2 knees.Results: There were no statistically significant differences in the visual analog scale score, ROM, thigh girth, HSS score, and complications between the 2 kness. The patients were unable to detect a difference in the functional recovery between their knees on postoperative day 3or at the 3 month follow-up.Conclusion: Betamethasone injections are ineffective locally for relieving pain, reducing swelling, and improving the postoperative ROM.Trial registration: Chinese Clinical Trial RegistryNumber: ChiCTR-OPC-17013503, Date of Registration: 2017-11-23 URL:http://www.chictr.org.cn/showproj.aspx?proj=23146

scholarly journals INTRAARTICULAR EPSILON AMINOCAPROIC ACID VERSUS TRANEXAMIC ACID IN TOTAL KNEE ARTHROPLASTY

2021 ◽  
Vol 29 (6) ◽  
pp. 312-315
Author(s):  
JOAO PAULO FERNANDES GUERREIRO ◽  
JOSE RODOLFO MARTINES BALBINO ◽  
BRUNO POSSANI RODRIGUES ◽  
MARCUS VINICIUS DANIELI ◽  
ALEXANDRE OLIVEIRA QUEIROZ ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Controlled Trial ◽  
Aminocaproic Acid ◽  
Osteoarthritis Of The Knee ◽  
Significant Difference ◽  
Total Knee ◽  
Double Blinded ◽  
Epsilon Aminocaproic Acid

ABSTRACT Objective: To examine and compare the clinical efficacy of intraarticular epsilon aminocaproic acid (EACA) and tranexamic acid (TXA) in total knee arthroplasty (TKA). Methods: This study was a prospective, single-center, double-blinded randomized controlled trial, including sixty patients with osteoarthritis of the knee divided into two groups of 30 patients. In the TXA group, 1 g of TXA (0.05 g/ml) was applied intraarticularly, and in the EACA group, 4 g of EACA (0.2 g/ml) was applied intraarticularly. Serum hemoglobin (Hgb) and hematocrit (Htb) were measured during the preoperatively and 24 and 48 hours postoperatively. The range of motion and pain were evaluated by clinical examination. To evaluate knee function before and 2 months after surgery, the Western Ontario and McMaster Universities Index (WOMAC) questionnaire was used. Results: In total, 56 (93.3%) patients were evaluated up to the second postoperative month. No significant difference between the groups (p > 0.05) was found in the decrease in Hgb or Htb at 24 or 48 hours. Regarding assessment of the pain, WOMAC score and gain in knee flexion, no significant advantages up to 60 days after surgery (p > 0.05) were found. Conclusions: The decrease in Hgb and Htb during the first 48 hours postoperatively and the risk of transfusion were similar with the intraarticular use of 1 g of TXA and 4 g of EACA in TKA. The possible benefits regarding knee pain, gain in flexion and function were also similar for the two drugs. Level of Evidence II, Randomized, Double-Blinded, Single-Centre, Prospective Clinical Trial.

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