scholarly journals Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome

2020 ◽  
Author(s):  
Sha Liu ◽  
Wenjing Hu ◽  
Yirui He ◽  
Ling Li ◽  
Hua Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Binary Logistic Regression ◽  
Nonparametric Test ◽  
Multivariate Regression Analysis ◽  
Roc Curve Analysis ◽  
Ovary Syndrome ◽  
Fetuin A ◽  
Diagnostic Guideline

Abstract Background: Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent.Methods: 207 subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t-test or Nonparametric test was used to detect differences between PCOS and control groups. Spearman’s correlation analysis was used to examine the association of the serum Fetuin-A with other parameters.Results: Our findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2 µg/L for most women without PCOS (95 %). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p < 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 µg/L.Conclusion: Blood Fetuin-A may be a useful biomarker for screening women for PCOS and IR.

scholarly journals Serum Fetuin-A levels were increased and associated with insulin resistance in women with polycystic ovary syndrome

2020 ◽  
Author(s):  
Sha Liu ◽  
Wenjing Hu ◽  
Yirui He ◽  
Ling Li ◽  
Hua Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Binary Logistic Regression ◽  
Nonparametric Test ◽  
Multivariate Regression Analysis ◽  
Roc Curve Analysis ◽  
Ovary Syndrome ◽  
Fetuin A ◽  
Diagnostic Guideline

Abstract Background: Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports on changes in circulating Fetuin-A concentrations in women with PCOS have been inconsistent.Methods: 207 subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t-test or Nonparametric test was used to detect differences between PCOS and control groups. The association of the serum Fetuin-A with other parameters was examined by spearman’s correlation analysis. Results: Our findings show that circulating Fetuin-A concentration ranged from 196.6 to 418.2 µg/L for most women without PCOS (95 %). Women with PCOS have higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p < 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the .occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 µg/L.Conclusion: Blood Fetuin-A may be a useful biomarker for screening women for PCOS and IR.

scholarly journals Serum Fetuin-A levels are increased and associated with insulin resistance in  women with polycystic ovary syndrome

2020 ◽  
Author(s):  
Sha Liu ◽  
Wenjing Hu ◽  
Yirui He ◽  
Ling Li ◽  
Hua Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Binary Logistic Regression ◽  
Nonparametric Test ◽  
Multivariate Regression Analysis ◽  
Roc Curve Analysis ◽  
Ovary Syndrome ◽  
Fetuin A ◽  
Diagnostic Guideline

Abstract Background: Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent. Methods: 207 subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t- test or Nonparametric test was used to detect differences between PCOS and control groups.Spearman’s correlation analysis was used to examine the association of the serum Fetuin-A with other parameters. Results: Our findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2 µg/L for most women without PCOS (95 %). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p < 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR, and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 µg/L. Conclusion: Blood Fetuin-A may be a useful biomarker for screening women for PCOS and IR.

scholarly journals Serum Fetuin-A levels were increased and associated with insulin resistance in women with polycystic ovary syndrome

2020 ◽  
Author(s):  
Sha Liu ◽  
Wenjing Hu ◽  
Yirui He ◽  
Ling Li ◽  
Hua Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Binary Logistic Regression ◽  
Multivariate Regression Analysis ◽  
Nonparametric Tests ◽  
Roc Curve Analysis ◽  
Ovary Syndrome ◽  
Fetuin A ◽  
Diagnostic Guideline

Abstract Background Insulin resistance (IR) is a common characteristic in women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports on changes in circulating Fetuin-A concentrations in women with PCOS have been inconsistent. Methods 207 subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t- test or Nonparametric tests was used to detect differences between PCOS and control groups. The association of the serum Fetuin-A with other parameters was examined by spearman’s correlation analysis. Results Our findings show that circulating Fetuin-A concentration ranged from 196.6 to 418.2 µg/L for most women without PCOS (95%). Women with PCOS have higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p < 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the .occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 µg/L. ConclusionBlood Fetuin-A may be a useful biomarker for screening women for PCOS and IR.

scholarly journals Serum Fetuin-A levels were increased and associated with insulin resistance in  women with polycystic ovary syndrome

2019 ◽  
Author(s):  
Sha Liu ◽  
Wenjing Hu ◽  
Yirui He ◽  
Ling Li ◽  
Hua Liu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Multivariate Regression Analysis ◽  
Cross Sectional Study ◽  
Roc Curve Analysis ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Fetuin A ◽  
Healthy Women

Abstract Background: Insulin resistance (IR) is a common characteristic in women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, in PCOS women, previous reports on changes in circulating Fetuin-A concentrations were inconsistent. Methods: A cross-sectional study was conducted, including 122 PCOS women and 85 healthy women. Circulating Fetuin-A levels were determined using an ELISA kit. Results: We found that circulating Fetuin-A concentration ranged from 196.6 to 418.2 µg/L for most normal women (95 %). Women with PCOS have higher circulating Fetuin-A levels than healthy women (437.9 ± 119.2 vs. 313.8 ± 60.4 μg/L; p <0.01). Serum Fetuin-A concentrations correlated positively with WHR, LDL-C, FIns, HOMA-IR, TEST and DHEA-S. Multivariate regression analysis showed that WHR, HOMA-IR and TEST were independent influencing factors of serum Fetuin-A. Binary logistic regression reaveled that serum Fetuin-A was associated with the .occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 µg/L. Conclusion: Blood Fetuin-A may be a useful biomarker for screening women with PCOS and IR.

Evaluation of the pathophysiological role of Fetuin A levels in adolescents with polycystic ovary syndrome

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Elvan Bayramoğlu ◽  
Semra Çetinkaya ◽  
Servan Özalkak ◽  
Erdal Kurnaz ◽  
Gülşah Demirci ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Ovary Syndrome ◽  
Fetuin A ◽  
Pathophysiological Role ◽  
Pcos Group ◽  
Natural Inhibitor

Abstract Objectives Polycystic ovary syndrome (PCOS) is an endocrinopathy, in which hyperandrogenism and hyperinsulinism have both occurred. Fetuin-A, a natural inhibitor of tyrosine kinase, leads to insulin resistance. The aim was to evaluate the relationship between fetuin-A and hyperandrogenism and hyperinsulinism and the role of fetuin-A in the pathophysiology of PCOS. Methods Thirty-eight cases with PCOS and 40 healthy adolescents were included in the study. PCOS and controls were divided into obese/non-obese subgroups. LH, FSH, total and free testosterone (TT, FT), SHBG, androstenedione, DHEAS were measured in patients with PCOS. Fasting glucose, insulin, lipid profile, AST, ALT, HsCRP, and fetuin levels of PCOS patients and healthy controls were also measured. Results Fetuin-A levels were higher in PCOS patients than in controls. In the obese-PCOS group, when compared to non-obese PCOS patients; the levels of SHBG and HDL were low while cholesterol, LDL, triglyceride, HOMA-IR, FT, FAI, and HSCRP levels were high, but Fetuin-A levels were similar. In the obese-PCOS group, fetuin-A levels were higher than in obese-controls. HOMA-IR and fetuin-A levels were higher in non-obese PCOS patients than in non-obese controls. In the PCOS group, fetuin-A was positively correlated with TT, FT, FAI and androstenedione and negatively correlated with SHBG. Regression analysis demonstrated that FT, SHBG, and androstenedione significantly predicted fetuin-A levels (R2=54%). In non-obese PCOS patients and controls, fetuin-A was positively correlated with insulin and HOMA-IR. Conclusions These results suggest a relationship between androgen levels and fetuin-A in PCOS cases, independent of insulin resistance, and may shed light on further studies.

Oxidative stress markers in women with polycystic ovary syndrome without insulin resistance

2018 ◽  
Author(s):  
Reveka Gyftaki ◽  
Sofia Gougoura ◽  
Nikolaos Kalogeris ◽  
Vasiliki Loi ◽  
George Koukoulis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Oxidative Stress Markers ◽  
Ovary Syndrome ◽  
Stress Markers
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