scholarly journals RNA Binding Protein-Mediated Immunosuppressive Tumor Microenvironment Contributes to Poor Prognosis in High-Grade Gliomas

2021 ◽  
Author(s):  
Wangxia Tong ◽  
Ning Luo ◽  
Shengyong Lan ◽  
Xinmei Zhou ◽  
Xiaodong Wen ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Rna Binding ◽  
High Grade ◽  
Immune Genes ◽  
Immune Infiltration ◽  
Predominant Type ◽  
Stromal Activation ◽  
High Grade Gliomas ◽  
Immunosuppressive Microenvironment ◽  
Immune Related Genes

Abstract The abnormal expression of RNA binding proteins (RBPs) in tumors can regulate the functions of immune genes and affect immune microenvironment. The characterization of immune infiltration and its regulatory mechanism from the perspective of RBPs and RBP-regulated immune genes in high-grade gliomas were comprehensively studied by bioinformatics. Prognosis-related RBPs and associated immune genes were obtained from the cancer genome atlas database (TCGA). By clustering RBPs, the potential relationship between the different clusters of RBPs expression and immune infiltration was explored. Immune-related RBP constructs immunosuppressive microenvironment in glioma by regulating immune genes and immune-related genes. Immunosuppression was the predominant type of phenotype with poor prognosis, while immunoinflammation was the predominant type of immunoinflammatory phenotype with good prognosis. RBP can construct immunosuppressive microenvironment by regulating immunosuppressive cells and stromal activation-related factors through directly and indirectly ways. Stromal activation plays a bridging role in tumor immunosuppressive regulation. The immunophenotyp depends on different enrichment states of immune-related RBP, which can change dynamically with the change of tumor pathological grade and affect the prognosis of patients.Our study suggests glioma related RBPs can potentially establish an immunosuppressive microenvironment by regulating immune genes and immune-related genes, which can be directly affected by RBPs clusters with distinct prognosis.

8720 POSTER Positive Osteopontin Expression in High Grade Gliomas Predicts Poor Prognosis

2011 ◽  
Vol 47 ◽  
pp. S580-S581
Author(s):  
P. Erpolat ◽  
P. Uyar Gocun ◽  
M. Akmansu ◽  
G. Ozgun ◽  
G. Akyol
Keyword(s):  
Poor Prognosis ◽  
High Grade ◽  
Osteopontin Expression ◽  
High Grade Gliomas

scholarly journals Tumour-associated microglia/macrophages predict poor prognosis in high-grade gliomas and correlate with an aggressive tumour subtype

2017 ◽  
Vol 44 (2) ◽  
pp. 185-206 ◽  
Author(s):  
M. D. Sørensen ◽  
R. H. Dahlrot ◽  
H. B. Boldt ◽  
S. Hansen ◽  
B. W. Kristensen
Keyword(s):  
Poor Prognosis ◽  
High Grade ◽  
High Grade Gliomas

scholarly journals TMIC-18TUMOR-ASSOCIATED MICROGLIA/MACROPHAGES ARE ASSOCIATED WITH POOR PROGNOSIS IN HIGH-GRADE GLIOMAS AND CONTRIBUTE TO THE GLIOBLASTOMA STEM CELL-LIKE NICHES

2015 ◽  
Vol 17 (suppl 5) ◽  
pp. v218.6-v218
Author(s):  
Mia Dahl Sørensen ◽  
Rikke Hedegaard Dahlrot ◽  
Steinbjørn Hansen ◽  
Bjarne Winther Kristensen
Keyword(s):  
Stem Cell ◽  
Poor Prognosis ◽  
High Grade ◽  
Glioblastoma Stem Cell ◽  
High Grade Gliomas

scholarly journals Aberrant expression of RSK1 characterizes high‐grade gliomas with immune infiltration

2019 ◽  
Vol 14 (1) ◽  
pp. 159-179 ◽  
Author(s):  
Glaucia N. M. Hajj ◽  
Fernanda F. Silva ◽  
Bárbara Bellis ◽  
Fernanda C. S. Lupinacci ◽  
Hermano M. Bellato ◽  
...  
Keyword(s):  
High Grade ◽  
Aberrant Expression ◽  
Immune Infiltration ◽  
High Grade Gliomas

scholarly journals Gene expression and immune infiltration in melanoma patients with different mutation burden

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Liwei Wang ◽  
Fu Chen ◽  
Rui Liu ◽  
Lei Shi ◽  
Guosheng Zhao ◽  
...  
Keyword(s):  
Cox Regression ◽  
Clinical Information ◽  
R Package ◽  
The Cancer Genome Atlas ◽  
Differentially Expressed ◽  
Survival Outcomes ◽  
Immune Genes ◽  
Immune Infiltration ◽  
Mutation Burden ◽  
Immune Related Genes

Abstract Background Immunotherapy is a vital component in cancer treatment. However, due to the complex genetic bases of cancer, a clear prediction index for efficacy has not been established. Tumor mutation burden (TMB) is one of the essential factors that affect immunotherapeutic efficacies, but it has not been determined whether the mutation is associated with the survival of Skin Cutaneous Melanoma (SKCM) patients. This study aimed at evaluating the correlation between TMB and immune infiltration. Methods Somatic mutation profiles (n = 467), transcriptome data (n = 471), and their clinical information (n = 447) of all SKCM samples were downloaded from The Cancer Genome Atlas (TCGA) database. For each sample, TMB was calculated as the number of variants per megabase. Based on K-M survival analysis, they were allocated into the high-TMB and low-TMB groups (the optimal cutoff was determined by the ‘surv_cutpoint’ algorithm of survival R package). Then, Gene ontology (GO) and Gene Set Enrichment Analyses (GSEA) were performed, with immune-associated biological pathways found to be significantly enriched in the low-TMB group. Therefore, immune genes that were differentially expressed between the two groups were evaluated in Cox regression to determine their prognostic values, and a four-gene TMB immune prognostic model (TMB-IP) was constructed. Results Elevated TMB levels were associated with better survival outcomes in SKCM patients. Based on the cutoff value in OS analysis, they were divided into high-TMB and low-TMB groups. GSEA revealed that the low-TMB group was associated with immunity while intersection analysis revealed that there were 38 differentially expressed immune-related genes between the two groups. Four TMB-associated immune genes were used to construct a TMB-IP model. The AUC of the ROC curve of this model reached a maximum of 0.75 (95%CI, 0.66–0.85) for OS outcomes. Validation in each clinical subgroup confirmed the efficacy of the model to distinguish between high and low TMB-IP score patients. Conclusions In SKCM patients, low TMB was associated with worse survival outcomes and enriched immune-associated pathways. The four TMB-associated immune genes model can effectively distinguish between high and low-risk patients.

scholarly journals Clinicopathological Significance of Nestin Expression as a Diagnostic and Prognostic Marker in Brain Gliomas, Independent of IDH Mutation

2021 ◽  
Author(s):  
Chang Gok Woo
Keyword(s):  
Poor Prognosis ◽  
Tissue Microarrays ◽  
Adult Brain ◽  
World Health ◽  
Low Grade ◽  
High Grade ◽  
Nestin Expression ◽  
High Grade Gliomas ◽  
Health Organization ◽  
Brain Gliomas

Abstract Background: Nestin, a type VI intermediate filament, is expressed in neuroepithelial cells during embryogenesis and has been expressed in various human tumors. Recent studies have reported that expression is associated with poor prognosis in brain tumors, but the results are inconclusive. In this study, we evaluated usefulness of Nestin expression using immunohistochemistry as a diagnostic and prognostic biomarker for IDH mutation and the new World Health Organization (WHO) classification.Methods: To investigate Nestin expression, immunohistochemistry was performed on 92 adult brain gliomas using tissue microarrays. We further analyzed the clinical characteristics and survival outcomes according to Nestin expression and examined its correlation with another glioma biomarker, IDH mutation.Results: Sixty patients (65.2%) were Nestin-positive (weak and strong). Nestin expression and intensity were significantly correlated with age, location, diagnosis, and IDH mutations. Old age and high-grade gliomas showed a higher frequency and stronger intensity of Nestin expression than those of young age and with low-grade gliomas (p<0.001). Gliomas with IDH mutations that are located in the frontal lobe showed no expression or had weak positivity. Multivariate analysis demonstrated that Nestin expression (weak, hazard ratio [HR] 5.39, p=0.036; strong, HR 8.43, p=0.007) and IDH wildtype (HR 7.63; p=.001) were significant independent prognostic factors. Moreover, patients with tumors expressing Nestin showed shorter survival (p<0.001).Conclusions: Nestin expression exhibits high intensity in high-grade gliomas and is a useful diagnostic marker. High expression and level of Nestin were significantly correlated with worse survival and was considered a significant marker of poor prognosis in new WHO classification, independent of IDH mutation.

scholarly journals Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0127976 ◽  
Author(s):  
Wei Du ◽  
Changhe Pang ◽  
Dongliang Wang ◽  
Qingjun Zhang ◽  
Yake Xue ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
High Grade ◽  
High Grade Gliomas
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