scholarly journals Atypical and Non-spontaneous Attentional Control in “just Look” Tasks for Face Recognition in ASD Children Revealed by Gaze Tracking Pupillometry

2021 ◽  
Author(s):  
Yuka Murofushi ◽  
Masaya Kubota ◽  
Ishiguro Akira ◽  
Itaru Hayakawa ◽  
Hiroshi Ozawa ◽  
...  
Keyword(s):  
Social Interaction ◽  
Executive Control ◽  
Pupil Diameter ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Typically Developing ◽  
Attentional Disengagement ◽  
Gaze Tracking ◽  
Attentional Function ◽  
Geometric Patterns

Abstract We hypothesized that abnormalities in social interaction and executive function may be related to fluctuations in pupil diameter, which reflect norepinephrine activity in terms of attentional function. We adopted “just look” tasks to examine spontaneous changes in attention. Twenty children with autism spectrum disorder (ASD) and 39 typically developing (TD) controls participated. Intragroup comparisons of differences in pupil diameter changes during a shift from a scrambled image to the original image (task 1-a), fixation on faces, letters, and geometric patterns (task 1-b), and pupil diameter changes during a shift from a nonsense image to a face-like image (task 2) were performed. In task 1-a, ASD children had prolonged pupil dilation after the shift in images, whereas the pupil contracted in TD children, indicating deficits in attentional disengagement in ASD children. In task 1-b, ASD children preferred geometric patterns over faces. In task 2, the rate of pupillary dilatation during the shift in images was lower in ASD children than in TD children. Therefore, ASD children appear to have abnormalities in spontaneous attention to faces, which function automatically in TD children. In conclusion, atypical attentional function may contribute to the manifestation of abnormalities in social interaction and executive control in ASD.

Disfluency Characteristics Observed in Young Children With Autism Spectrum Disorders: A Preliminary Report

2010 ◽  
Vol 20 (2) ◽  
pp. 42-50 ◽  
Author(s):  
Laura W. Plexico ◽  
Julie E. Cleary ◽  
Ashlynn McAlpine ◽  
Allison M. Plumb
Keyword(s):  
Autism Spectrum Disorders ◽  
Young Children ◽  
Children With Autism ◽  
Descriptive Study ◽  
Autism Spectrum ◽  
Typically Developing ◽  
Children With Asd ◽  
Young Children With Autism ◽  
Spectrum Disorders ◽  
Developmental Stuttering

This descriptive study evaluates the speech disfluencies of 8 verbal children between 3 and 5 years of age with autism spectrum disorders (ASD). Speech samples were collected for each child during standardized interactions. Percentage and types of disfluencies observed during speech samples are discussed. Although they did not have a clinical diagnosis of stuttering, all of the young children with ASD in this study produced disfluencies. In addition to stuttering-like disfluencies and other typical disfluencies, the children with ASD also produced atypical disfluencies, which usually are not observed in children with typically developing speech or developmental stuttering. (Yairi & Ambrose, 2005).

scholarly journals Autism Detection in Children by Combined Use of Gaze Preference and the M-CHAT-R in a Resource-Scarce Setting

2021 ◽  
Vol 51 (3) ◽  
pp. 994-1006
Author(s):  
Kelly Jensen ◽  
◽  
Sassan Noazin ◽  
Leandra Bitterfeld ◽  
Andrea Carcelen ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Typically Developing ◽  
Early Screening ◽  
Resource Limited Settings ◽  
Children With Asd ◽  
Resource Limited ◽  
Combined Use ◽  
Better Than

AbstractMost children with autism spectrum disorder (ASD), in resource-limited settings (RLS), are diagnosed after the age of four. Our work confirmed and extended results of Pierce that eye tracking could discriminate between typically developing (TD) children and those with ASD. We demonstrated the initial 15 s was at least as discriminating as the entire video. We evaluated the GP-MCHAT-R, which combines the first 15 s of manually-coded gaze preference (GP) video with M-CHAT-R results on 73 TD children and 28 children with ASD, 36–99 months of age. The GP-MCHAT-R (AUC = 0.89 (95%CI: 0.82–0.95)), performed significantly better than the MCHAT-R (AUC = 0.78 (95%CI: 0.71–0.85)) and gaze preference (AUC = 0.76 (95%CI: 0.64–0.88)) alone. This tool may enable early screening for ASD in RLS.

scholarly journals Identifying the signature of prospective motor control in children with autism

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Andrea Cavallo ◽  
Luca Romeo ◽  
Caterina Ansuini ◽  
Francesca Battaglia ◽  
Lino Nobili ◽  
...  
Keyword(s):  
Motor Control ◽  
Hand Movement ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Typically Developing ◽  
Movement Kinematics ◽  
Typically Developing Children ◽  
Phenotypic Marker ◽  
Quantitative Evidence ◽  
Movement Data

AbstractFailure to develop prospective motor control has been proposed to be a core phenotypic marker of autism spectrum disorders (ASD). However, whether genuine differences in prospective motor control permit discriminating between ASD and non-ASD profiles over and above individual differences in motor output remains unclear. Here, we combined high precision measures of hand movement kinematics and rigorous machine learning analyses to determine the true power of prospective movement data to differentiate children with autism and typically developing children. Our results show that while movement is unique to each individual, variations in the kinematic patterning of sequential grasping movements genuinely differentiate children with autism from typically developing children. These findings provide quantitative evidence for a prospective motor control impairment in autism and indicate the potential to draw inferences about autism on the basis of movement kinematics.

scholarly journals Parent-mediated early intervention for young children with autism spectrum disorders (ASD)

2016 ◽  
Vol 22 (3) ◽  
pp. 146-146 ◽  
Author(s):  
Inalegwu P. Oono ◽  
Emma J. Honey ◽  
Helen McConachie
Keyword(s):  
Autism Spectrum Disorders ◽  
Early Intervention ◽  
Social Interaction ◽  
Young Children ◽  
Cochrane Review ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Young Children With Autism ◽  
Spectrum Disorders

Young children with autism spectrum disorders (ASD) have impairments in the areas of communication and social interaction and often display repetitive or non-compliant behaviour. This early pattern of difficulties is a challenge for parents. Therefore, approaches that help parents develop strategies for interaction and management of behaviour are an obvious route for early intervention in ASD. This review updates a Cochrane review first published in 2002 but is based on a new protocol.

scholarly journals A combined prosodic and linguistic treatment approach for language-communication skills in children with autism spectrum disorders: A proof-of-concept study

2016 ◽  
Vol 6 (1) ◽  
pp. 8
Author(s):  
Silva Kuschke ◽  
Bart Vinck ◽  
Salomé Geertsema
Keyword(s):  
Social Interaction ◽  
Statistical Significance ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Listening Skills ◽  
Language Therapy ◽  
Baseline Design ◽  
Traditional Language ◽  
Pragmatic Skills ◽  
Pre Treatment

<p>This study aimed to determine whether the use of prosodically varied speech within a traditional language therapy framework had any effect on the listening skills, pragmatic skills and social interaction behaviour of three children with autism spectrum disorder (ASD). A single participant multiple baseline design across behaviours was implemented. Three participants with ASD were selected for this research. The listening skills, pragmatic skills and social interaction behaviour of the participants were compared before treatment, after a 3-week <br />period of treatment and after a 2-week withdrawal period from treatment, utilising prosodically varied speech within a traditional language therapy approach. Statistical significance was not calculated for each individual due to the limited data, but visual inspection indicated that all the participants showed positive behavioural changes in performance across all areas after 3 weeks of treatment, independent of their pre-treatment performance level. The use of <br />prosodically varied speech within a traditional language therapy framework appears to be a viable form of treatment for children with ASD.</p>

scholarly journals Early screening of autism spectrum disorder using cry features

2020 ◽  
Author(s):  
Aida Khozaei ◽  
Hadi Moradi ◽  
Reshad Hosseini ◽  
Hamidreza Pouretemad ◽  
Bahareh Eskandari
Keyword(s):  
Autism Spectrum Disorder ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
New Classification ◽  
Early Screening ◽  
Classification Approach ◽  
Children With Asd ◽  
Sensitivity Specificity

AbstractDue to the importance of automatic and early autism screening, in this paper, a cry-based screening approach for children with Autism Spectrum Disorder (ASD) is introduced. During the study, we realized that the ASD specific features are not necessarily observable among all children with ASD and among all instances of each child. Therefore, we proposed a new classification approach to be able to find such features and their corresponding instances. We tested the proposed approach and found two features that can be used to distinguish groups of children with ASD from Typically Developing (TD) children. In other words, these features are present in subsets of children with ASD not all of them. The approach has been tested on a dataset including 14 boys and 7 girls with ASD and 14 TD boys and 7 TD girls, between 18 to 53 months old. The sensitivity, specificity, and precision of the proposed approach for boys were 85.71%, 100%, and 92.85%, respectively. These measures were 71.42%, 100%, and 85.71% for girls, respectively.

scholarly journals Altered Metabolism of Mothers of Young Children with Autism Spectrum Disorder: A Case Control Study

2020 ◽  
Author(s):  
Kathryn Hollowood-Jones ◽  
James B. Adams ◽  
Devon M. Coleman ◽  
Sivapriya Ramamoorthy ◽  
Stephan Melnyk ◽  
...  
Keyword(s):  
Young Children ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Conjugated Molecules ◽  
Metabolic Analysis ◽  
Transsulfuration Pathway ◽  
Young Children With Autism ◽  
One Carbon Metabolism

Abstract Background: Previous research studies have demonstrated abnormalities in the metabolism of mothers of young children with autism.Method: Metabolic analysis was performed on blood samples from 30 mothers of young children with Autism Spectrum Disorder (ASD-M) and from 29 mothers of young typically-developing children (TD-M). Targeted metabolic analysis focusing on the folate one-carbon metabolism (FOCM) and the transsulfuration pathway (TS) as well as broad metabolic analysis were performed. Statistical analysis of the data involved both univariate and multivariate statistical methods.Results: Univariate analysis revealed significant differences in 5 metabolites from the folate one-carbon metabolism and the transsulfuration pathway and differences in an additional 48 metabolites identified by broad metabolic analysis, including lower levels of many carnitine-conjugated molecules. Multivariate analysis with leave-one-out cross-validation allowed classification of samples as belonging to one of the two groups of mothers with 93% sensitivity and 97% specificity with five metabolites. Furthermore, each of these five metabolites correlated with 8-15 other metabolites indicating that there are five clusters of correlated metabolites. In fact, all but 5 of the 50 metabolites with the highest area under the receiver operating characteristic curve were associated with the five identified groups. Many of the abnormalities appear linked to low levels of folate, vitamin B12, and carnitine-conjugated molecules.Conclusions: Mothers of children with ASD have many significantly different metabolite levels compared to mothers of typically developing children at 2-5 years after birth.

scholarly journals Autism Spectrum Disorder (ASD); Symptoms, Causes, Diagnosis, Intervention, and Counseling Needs of the Families in Jordan

2019 ◽  
Vol 13 (5) ◽  
pp. 48
Author(s):  
Emad Mohammad ali ◽  
Fatimah eid ziad Al- Adwan ◽  
Yazan M. Al-Naimat
Keyword(s):  
Autism Spectrum Disorder ◽  
Social Interaction ◽  
Nonverbal Communication ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Early Age ◽  
Behavioral Patterns ◽  
Dramatic Rise ◽  
Counseling Needs

Autism Spectrum Disorder (ASD) is one of the most confusing disorders for which not only no exact cause has been identified, but also no definitive cure has been found yet. Autism is a disorder that is usually observed on the child at an early age, affecting various developmental aspects. Its development is abnormal. It shows an imbalance in its social interaction, characterized by repetition of certain behavioral patterns and challenges in verbal and nonverbal communication with others. Over the last few decades, its prevalence showed a dramatic rise; an observation that encouraged many researchers across the globe to try to explore all its aspects from etiology to diagnosis and intervention. Because of the difficulties in teaching children with autism, the families in Jordan encounter many challenges and stresses. This paper discusses the Autism Spectrum Disorder (ASD); Symptoms, Causes, Diagnosis, treatment, types and the counseling needs of the families in Jordan.

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