scholarly journals Left Ventricular Morphology in Patients with Aortic Coarctation and Bicuspid Aortic Valve: Novel Insights from a Statistical Shape Modelling Framework

2022 ◽  
Author(s):  
Froso Sophocleous ◽  
Lucy Standen ◽  
Gemina Doolub ◽  
Reem Laymouna ◽  
Chiara Bucciarelli-Ducci ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Coarctation ◽  
Three Dimensional ◽  
Left Ventricular ◽  
Lv Function ◽  
Shape Modelling ◽  
Functional Implications ◽  
Statistical Shape ◽  
Statistical Shape Modelling

Abstract Background The functional implications of left ventricular (LV) morphological characterization in congenital heart disease (CHD) are not widely explored. This study qualitatively and quantitatively assessed LV shape associations with a) LV function and b) thoracic aortic morphology in patients with aortic coarctation (CoA) with/without bicuspid aortic valve (BAV). Methods A statistical shape modelling (SSM) framework was employed to analyse three-dimensional (3D) LV shapes from cardiac magnetic resonance (CMR) data in isolated CoA (n=25), CoA+BAV (n=30), isolated BAV (n=30), and age-matched healthy controls (n=25). Average 3D templates and deformations were computed. Correlations between shape data and CMR-derived morphometric parameters (i.e. sphericity, conicity) or global and apical strain values were assessed to elucidate possible functional implications. The relationship between LV shape features and arch architecture was also explored. Results The LV template was shorter and more spherical in CoA patient and LV sphericity was associated (p≤0.04) with lower global longitudinal, radial and circumferential strain, irrespective of the presence of aortic stenosis and/or regurgitation. Conversely, LV strain was not associated with arch architecture. Conclusions Differences in LV morphology were observed between CoA and BAV patients. Increasing LV sphericity was associated with reduced strain, independent of aortic arch architecture and functional aortic valve disease.

Late appearance of left ventricular non-compaction in a patient with aortic coarctation and bicuspid aortic valve

2016 ◽  
Vol 32 (5) ◽  
pp. 741-742 ◽  
Author(s):  
Maria Bonou ◽  
Eva D. Papadimitraki ◽  
Nikolaos Alexopoulos ◽  
Ioannis Paizis ◽  
Spiros Rammos ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Coarctation ◽  
Left Ventricular

scholarly journals Left ventricular non-compaction associated with bicuspid aortic valve and aortic coarctation

2018 ◽  
Vol 88 (5) ◽  
pp. 507-508
Author(s):  
Nestor A. Parra-Ordoñez ◽  
Nydia Avila-Vanzzini ◽  
Nilda Espinola-Zavaleta
Keyword(s):  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Aortic Coarctation ◽  
Left Ventricular

Left ventricular non-compaction in a child with bicuspid aortic valve and aortic coarctation

2019 ◽  
Vol 29 (09) ◽  
pp. 1208-1210
Author(s):  
Ageliki Karatza ◽  
Konstantinos S. Mylonas ◽  
Aphrodite Tzifa
Keyword(s):  
Heart Failure ◽  
Aortic Valve ◽  
Bicuspid Aortic Valve ◽  
Balloon Angioplasty ◽  
Cardiac Mri ◽  
Aortic Coarctation ◽  
Left Ventricular

AbstractWe present the case of a 3-year-old boy with bicuspid aortic valve, aortic coarctation, and left ventricular non-compaction. The diagnosis was made post-natally with ultrasonography and was verified by cardiac MRI. Aortic coarctation was initially repaired surgically. At age 3 months, recoarctation and heart failure developed. Balloon angioplasty was performed with immediate improvement. At age 3 years, the patient remains asymptomatic and normotensive.

Statistical shape modelling to analyse the talus in paediatric clubfoot

2021 ◽  
pp. 095441192110121
Author(s):  
Yixuan Feng ◽  
Aaron Bishop ◽  
Daniel Farley ◽  
Joseph Mitchell ◽  
Kenneth Noonan ◽  
...  
Keyword(s):  
Three Dimensional ◽  
3D Models ◽  
Magnetic Resonance Images ◽  
Idiopathic Clubfoot ◽  
Bone Morphology ◽  
Shape Modelling ◽  
Statistical Shape ◽  
Statistical Shape Modelling ◽  
The One ◽  
Made In

One fifth of idiopathic clubfoot deformities cannot be fully corrected by Serial Ponseti casting and deformity recurs in 20%–30% of cases. To avoid x-ray exposure, the joints with largely unossified bones are diagnosed with magnetic resonance images (MRI). Typically, geometric measurements are made in the MRI planes; however, this method is inaccurate compared to measurements on three-dimensional (3D) models of the joint. More accurate measurements using the 3D bone shapes may be better at identifying differences between groups; and therefore, improve diagnosis. The entire set of shape features from MRI can be analysed simultaneously through statistical shape modelling (SSM) which assesses bone morphology of clubfoot in a more sensitive way. A method for SSM of the talus is developed in this study and the shape of the normal talus is compared with the one in clubfeet with residual deformity through both geometric measurements and SSM. Significant differences between two groups were found by both methods; and therefore, might contribute to improve diagnosis of clubfoot.

scholarly journals Echocardiographic assessment of global left ventricular function in mice

2009 ◽  
Vol 43 (2) ◽  
pp. 127-137 ◽  
Author(s):  
Jörg Stypmann ◽  
Markus A Engelen ◽  
Clemens Troatz ◽  
Markus Rothenburger ◽  
Lars Eckardt ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Wall Stress ◽  
Left Ventricular ◽  
Lv Function ◽  
Mean Velocity ◽  
Global Left Ventricular ◽  
Mitral Inflow ◽  
Strain And Strain Rate ◽  
Echocardiographic Assessment ◽  
Murine Echocardiography

Doppler-echocardiographic assessment of cardiovascular structure and function in murine models has developed into one of the most commonly used non-invasive techniques during the last decades. Recent technical improvements even expanded the possibilities. In this review, we summarize the current options to assess global left ventricular (LV) function in mice using echocardiographic techniques. In detail, standard techniques as structural and functional assessment of the cardiovascular phenotype using one-dimensional M-mode echocardiography, two-dimensional B-mode echocardiography and spectral Doppler signals from mitral inflow respective aortal outflow are presented. Further pros and contras of recently implemented techniques as three-dimensional echocardiography and strain and strain rate measurements are discussed. Deduced measures of LV function as the myocardial performance index according to Tei, estimation of the mean velocity of circumferential fibre shortening, LV wall stress and different algorithms to estimate the LV mass are described in detail. Last but not least, specific features and limitations of murine echocardiography are presented. Future perspectives in respect to new examination techniques like targeted molecular imaging with advanced ultrasound contrast bubbles or improvement of equipment like new generation matrix transducers for murine echocardiography are discussed.

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