scholarly journals Exploring Young Adulthood Psychopathology Networks Related to Depression Using Partial Correlation Network and Bayesian Network

Author(s):  
Min Seob Kim ◽  
Bumseok Jeong

Abstract To characterize young adulthood depression is complicated because it is entangled with a broad spectrum of symptoms as well as traumatic experiences during development. However, previous symptom network studies have focused on undirected transdiagnostic association among depression and anxiety symptoms. Our study investigated both undirected and directed connections among variables potentially associated with depression, such as anxiety, addiction, subjective distress caused by traumatic events, perceived emotional adversities, and support systems. Both the regularized partial correlation network analysis and Bayesian network analysis were applied to 579 subjects screened for depression. Anxiety-related symptoms played a role as a hub node in the partial correlation network and Bayesian network. The vulnerability analysis of the partial correlation network showed that verbal abuse, social anxiety, concentration problems, and suicidal ideation had the strongest influence on changes in the network’s topology. In the Bayesian network analysis, loss of interest, depressed mood, and parental verbal abuse were located as parent nodes in the directed acyclic graph. In the aspect of disease networks, more attention should be paid to certain variables encompassing various domains as well as depressive symptoms in young adults’ mental health management.

2019 ◽  
Vol 4 (3) ◽  
pp. 204-223
Author(s):  
Toby Hopp

Although online political incivility has increasingly become an object of scholarly inquiry, there exists little agreement on the construct’s precise definition. The goal of this work was therefore to explore the relational dynamics among previously identified dimensions of online political incivility. The results of a regularized partial correlation network indicated that a communicator’s desire to exclude attitude-discrepant others from discussion played an especially influential role in the variable network. The data also suggested that certain facets of incivility may be likely to be deployed together. Specifically, the data suggested the existence of two identifiable groupings of incivility factors: (1) variables pertaining to violation of speech-based norms and (2) variables pertaining to the violation of the inclusion-based norms that underlie democratic communication processes. These results are discussed in the context of political discussion and deliberation.


2021 ◽  
Vol 91 ◽  
pp. 101995
Author(s):  
Yue Wang ◽  
Collin Wai Hung Wong ◽  
Tommy King-Yin Cheung ◽  
Edmund Yangming Wu

2020 ◽  
pp. 003329412097815
Author(s):  
Giovanni Briganti ◽  
Donald R. Williams ◽  
Joris Mulder ◽  
Paul Linkowski

The aim of this work is to explore the construct of autistic traits through the lens of network analysis with recently introduced Bayesian methods. A conditional dependence network structure was estimated from a data set composed of 649 university students that completed an autistic traits questionnaire. The connectedness of the network is also explored, as well as sex differences among female and male subjects in regard to network connectivity. The strongest connections in the network are found between items that measure similar autistic traits. Traits related to social skills are the most interconnected items in the network. Sex differences are found between female and male subjects. The Bayesian network analysis offers new insight on the connectivity of autistic traits as well as confirms several findings in the autism literature.


2009 ◽  
Vol 47 (2) ◽  
pp. 206-214 ◽  
Author(s):  
J.E. Martín ◽  
T. Rivas ◽  
J.M. Matías ◽  
J. Taboada ◽  
A. Argüelles

2021 ◽  
pp. 1-11
Author(s):  
Xuewei Wang ◽  
Hai Bui ◽  
Prashanthi Vemuri ◽  
Jonathan Graff-Radford ◽  
Clifford R. Jack Jr ◽  
...  

Background: Lipid alterations contribute to Alzheimer’s disease (AD) pathogenesis. Lipidomics studies could help systematically characterize such alterations and identify potential biomarkers. Objective: To identify lipids associated with mild cognitive impairment and amyloid-β deposition, and to examine lipid correlation patterns within phenotype groups Methods: Eighty plasma lipids were measured using mass spectrometry for 1,255 non-demented participants enrolled in the Mayo Clinic Study of Aging. Individual lipids associated with mild cognitive impairment (MCI) were first identified. Correlation network analysis was then performed to identify lipid species with stable correlations across conditions. Finally, differential correlation network analysis was used to determine lipids with altered correlations between phenotype groups, specifically cognitively unimpaired versus MCI, and with elevated brain amyloid versus without. Results: Seven lipids were associated with MCI after adjustment for age, sex, and APOE4. Lipid correlation network analysis revealed that lipids from a few species correlated well with each other, demonstrated by subnetworks of these lipids. 177 lipid pairs differently correlated between cognitively unimpaired and MCI patients, whereas 337 pairs of lipids exhibited altered correlation between patients with and without elevated brain amyloid. In particular, 51 lipid pairs showed correlation alterations by both cognitive status and brain amyloid. Interestingly, the lipids central to the network of these 51 lipid pairs were not significantly associated with either MCI or amyloid, suggesting network-based approaches could provide biological insights complementary to traditional association analyses. Conclusion: Our attempt to characterize the alterations of lipids at network-level provides additional insights beyond individual lipids, as shown by differential correlations in our study.


Sign in / Sign up

Export Citation Format

Share Document