scholarly journals Post-Traumatic Exogenous Endophthalmitis Caused By Nocardia Farcinica

2021 ◽  
Author(s):  
Marie Česká Burdová ◽  
Kateřina Donátová ◽  
Gabriela Mahelková ◽  
Vanda Chrenková ◽  
Dagmar Dotřelová
Keyword(s):  
Anterior Chamber ◽  
Infectious Agent ◽  
Corneal Injury ◽  
Nocardia Farcinica ◽  
Complicated Course ◽  
Post Traumatic ◽  
Exogenous Endophthalmitis ◽  
Treatment Procedures

Abstract A case report of post-traumatic exogenous endophthalmitis caused by Nocardia farcinica, including treatment procedures, microbiology examination, and systemic medications. A 23-year-old male suffered a penetrating corneal injury that was treated with sutures. The sutures were individually removed during the 4th and 5th months after surgery. On the thirteenth day after the final suture was removed, an anterior uveitis developed and progressed to whitish, plump, nodular, and tufted exudates within the anterior chamber over the next 10 days; this led to an indication for intraocular surgery. Anterior chamber lavage and resection of solid fibrinous exudates (using a vitrectomy knife) for a complete microbiological examination were performed. Nocardia farcinica was identified. Systemic medications were chosen according to sensitivity, and a fixed combination of sulfamethoxazole 400 mg/trimethoprim 80 mg was administered long-term (months). After a complicated course, the final visual acuity was 0.5. In this case, accurate, early detection of an atypical infectious agent and determination of its sensitivity to antibiotic treatment enabled effective treatment that achieved the best functional and anatomical results under the circumstances.

scholarly journals Post-traumatic exogenous endophthalmitis caused by Nocardia farcinica

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marie Česká Burdová ◽  
Kateřina Donátová ◽  
Gabriela Mahelková ◽  
Vanda Chrenková ◽  
Dagmar Dotřelová
Keyword(s):  
Anterior Chamber ◽  
Fixed Combination ◽  
Infectious Agent ◽  
Corneal Injury ◽  
Nocardia Farcinica ◽  
Post Traumatic ◽  
Exogenous Endophthalmitis ◽  
Treatment Procedures

AbstractA case report of post-traumatic exogenous endophthalmitis caused by Nocardia farcinica, including treatment procedures, microbiology examination, and systemic medications. A 23-year-old male suffered a penetrating corneal injury that was treated with sutures. On the thirteenth day after the final suture was removed, an anterior uveitis developed and progressed to whitish, plump, nodular, and tufted exudates within the anterior chamber over the next 10 days; this led to an indication for intraocular surgery. Anterior chamber lavage and resection of solid fibrinous exudates (using a vitrectomy knife) for a complete microbiological examination were performed. Nocardia farcinica was identified. Systemic medications were chosen according to sensitivity, and a fixed combination of sulfamethoxazole 400 mg/trimethoprim 80 mg was administered long-term (months). In this case, accurate, early detection of an atypical infectious agent and determination of its sensitivity to antibiotic treatment enabled effective treatment that achieved the best functional and anatomical results under the circumstances.

scholarly journals Cyclosporine toxicity in rabbits

1986 ◽  
Vol 20 (3) ◽  
pp. 213-220 ◽  
Author(s):  
A. Gratwohl ◽  
I. Riederer ◽  
E. Graf ◽  
B. Speck
Keyword(s):  
Infectious Agent ◽  
Dosage Level ◽  
Blood Concentrations ◽  
Serial Determination ◽  
Loss Of Weight ◽  
Undigested Food ◽  
Reduced Toxicity ◽  
Dose Dependent

Rabbits treated with an immunosuppressive dose of cyclosporine for a prolonged period of time developed a clinically distinct toxic syndrome characterized by wasting, loss of weight, reduced food and water consumption and reduced movement. Ultimately 74 of 153 animals died within 60 days of treatment with a distended stomach and intestines full of dry undigested food. The syndrome was dose dependent but seemed unrelated to the route of administration. It occurred in two strains and two different colonies. No infectious agent was implicated. Histological examination and a variety of laboratory tests did not elucidate the syndrome. It could not be prevented by drugs that increased bowel movement or gastric emptying and was more pronounced in animals given additional indomethacin. Reduction of cyclosporine dose reduced toxicity but at the expense of reduced immunosuppression. We were unable to define a therapeutic non-toxic range by serial determination of cyclosporine blood concentrations. This highlights the difficulty in obtaining a therapeutic dosage level in rabbits on long-term cyclosporine immunosuppression.

Preparation And elemental analysis of ancient fibers

1987 ◽  
Vol 45 ◽  
pp. 410-411
Author(s):  
Allen Angel ◽  
Kathryn A. Jakes
Keyword(s):  
Cross Sections ◽  
Physical Structure ◽  
Energy Dispersive ◽  
Archaeological Sites ◽  
X Ray ◽  
Long Term Storage ◽  
Backscattered Electron ◽  
Electron Imaging

Fabrics recovered from archaeological sites often are so badly degraded that fiber identification based on physical morphology is difficult. Although diagenetic changes may be viewed as destructive to factors necessary for the discernment of fiber information, changes occurring during any stage of a fiber's lifetime leave a record within the fiber's chemical and physical structure. These alterations may offer valuable clues to understanding the conditions of the fiber's growth, fiber preparation and fabric processing technology and conditions of burial or long term storage (1).Energy dispersive spectrometry has been reported to be suitable for determination of mordant treatment on historic fibers (2,3) and has been used to characterize metal wrapping of combination yarns (4,5). In this study, a technique is developed which provides fractured cross sections of fibers for x-ray analysis and elemental mapping. In addition, backscattered electron imaging (BSI) and energy dispersive x-ray microanalysis (EDS) are utilized to correlate elements to their distribution in fibers.

Improvement Of Curvilinear Diagrams Of Concrete Deformation

2019 ◽  
pp. 99-104
Keyword(s):  
Reinforced Concrete ◽  
Peak Load ◽  
Experimental Studies ◽  
Concrete Structures ◽  
Deformation Model ◽  
Reinforced Concrete Structures ◽  
Significant Difference ◽  
Deformation Diagrams

Problems when calculating reinforced concrete structures based on the concrete deformation under compression diagram, which is presented both in Russian and foreign regulatory documents on the design of concrete and reinforced concrete structures are considered. The correctness of their compliance for all classes of concrete remains very approximate, especially a significant difference occurs when using Euronorm due to the different shape and sizes of the samples. At present, there are no methodical recommendations for determining the ultimate relative deformations of concrete under axial compression and the construction of curvilinear deformation diagrams, which leads to limited experimental data and, as a result, does not make it possible to enter more detailed ultimate strain values into domestic standards. The results of experimental studies to determine the ultimate relative deformations of concrete under compression for different classes of concrete, which allowed to make analytical dependences for the evaluation of the ultimate relative deformations and description of curvilinear deformation diagrams, are presented. The article discusses various options for using the deformation model to assess the stress-strain state of the structure, it is concluded that it is necessary to use not only the finite values of the ultimate deformations, but also their intermediate values. This requires reliable diagrams "s–e” for all classes of concrete. The difficulties of measuring deformations in concrete subjected to peak load, corresponding to the prismatic strength, as well as main cracks that appeared under conditions of long-term step loading are highlighted. Variants of more accurate measurements are proposed. Development and implementation of the new standard GOST "Concretes. Methods for determination of complete diagrams" on the basis of the developed method for obtaining complete diagrams of concrete deformation under compression for the evaluation of ultimate deformability of concrete under compression are necessary.

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