scholarly journals Prevalence of Human Leukocyte Antigen HLA-B*57:01 in Individuals with HIV in West and Central Africa

Author(s):  
Malewe KOLOU ◽  
Armel PODA ◽  
Zellica DIALLO ◽  
Esther KONOU ◽  
Tatiana DOKPOMIWA ◽  
...  

Abstract Background: The presence of the human leukocyte antigen HLA-B*57:01 is associated with the development of a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*57:01 prevalence in individuals with HIV-1 in Africa. This study aimed to estimate HLA-B*57:01 prevalence in individuals with HIV-1 in West and Central Africa. Methods: A cross-sectional study was conducted in four countries in West and central Africa (Burkina-Faso, Côte d’Ivoire, Gabon, and Togo) from January 2016 to February 2020 to determine the status of HLA-B*5701 in adults with HIV-1. The presence of HLA-B*57:01 was determined by using Single Specific Primer-Polymerase Chain Reaction (SSP-PCR) in blood samples. Prevalence rates were stratified based on country. Results: A total of 4,016 (69.8% women) individuals with HIV were enrolled. Their median age was 45, and the interquartile range was 38-52. We included 500 (12.4%) patients in Burkina-Faso, 1,453 (36.2%) in Côte d’Ivoire, 951 (23.7%) in Gabon, and 1,112 (27.7%) in Togo. The overall HLA-B*57:01 prevalence was 0.1% [95% CI: 0.0–0.2%]. The prevalence of HLA-B*57:01 was similar according to the four countries. Only one case was reported in each country except Togo, with no cases.Conclusions: HLA-B*57:01 prevalence is low in individuals with HIV in West and central Africa, and there is no difference among countries. This study does not confirm the utility of HLA-B*57:01 allele testing in this region.

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Malewe Kolou ◽  
Armel Poda ◽  
Zelica Diallo ◽  
Esther Konou ◽  
Tatiana Dokpomiwa ◽  
...  

Abstract Background The presence of the human leukocyte antigen HLA-B*57:01 is associated with the development of a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*57:01 prevalence in individuals with HIV-1 in Africa. This study aimed to estimate HLA-B*57:01 prevalence in individuals with HIV-1 in West and Central Africa. Methods A cross-sectional study was conducted in four countries in West and central Africa (Burkina-Faso, Côte d’Ivoire, Gabon, and Togo) from January 2016 to February 2020 to determine the status of HLA-B*57:01 in adults with HIV-1. The presence of HLA-B*57:01 was determined by using Single Specific Primer-Polymerase Chain Reaction (SSP-PCR) in blood samples. Prevalence rates were stratified based on country. Results A total of 4016 (69.8% women) individuals with HIV were enrolled. Their median age was 45, and the interquartile range was 38–52. We included 500 (12.4%) patients in Burkina-Faso, 1453 (36.2%) in Côte d’Ivoire, 951 (23.7%) in Gabon, and 1112 (27.7%) in Togo. The overall HLA-B*57:01 prevalence was 0.1% [95% CI: 0.0–0.2%]. The prevalence of HLA-B*57:01 was similar according to the four countries. Only one case was reported in each country except Togo, with no cases. Conclusions HLA-B*57:01 prevalence is low in individuals with HIV in West and central Africa, and there is no difference among countries. This study does not confirm the utility of HLA-B*57:01 allele testing for abacavir use in this region.


Author(s):  
Sylvain Morin ◽  
Alice Ainsa ◽  
Raoufou Radji ◽  
Anne-Sophie Archambeau ◽  
Hervé Chevillotte ◽  
...  

The label transcription and imaging of specimens in key African herbaria has been ongoing since the early 2000s. Many collections in Benin, Cameroon, Côte d’Ivoire, Gabon, Guinea Conakry, and Togo are now fully transcribed and partially digitized. More than 200 000 transcribed specimens are available with the following distribution: Benin: 45 000 Cameroon: 70 000 Côte d’Ivoire: 18 000 Gabon: 70 000 Guinea Conakry: 5 000 Togo: 15 000 Benin: 45 000 Cameroon: 70 000 Côte d’Ivoire: 18 000 Gabon: 70 000 Guinea Conakry: 5 000 Togo: 15 000 In April 2021, a BID project was started to deliver a regional data platform of West and Central African herbaria. Biodiversity Information for Development (BID) is a multi-year programme funded by the European Union and led by GBIF with the aim of enhancing capacity for effective mobilization and use of biodiversity data in research and policy in the 'ACP' nations of sub-Saharan Africa, the Caribbean and the Pacific. Our project's funding runs from April 2021 to April 2023. At this stage of the project, we are working on defining the information technology (IT) architecture (Fig. 1) and selecting the tools that we will be using to achieve our goals. In the talk, we will present our conclusions through architecture schemas and tools demonstrations. Each of the 6 countries will have its own PostgreSQL database, storing its data. They will also have access to the RIHA data management platform (Réseau Informatique des Herbiers d'Afrique / Digital Network of African Herbaria). This is a web application, developed in PHP, allowing full management of the data by herbarium administrators (Fig. 2). An Integrated Publishing Toolkit (IPT) will fetch these herbaria data from the databases, create the Darwin Core archives, and connect these data automatically to gbif.org on a periodic basis (Fig. 3). On the databases, we will use a PostgreSQL view to ease conversion from the RIHA data model to the Darwin Core model. On the IPT, we will create one dataset per country, linked to each PostgreSQL view. The SQL query will be configured to only fetch validated data, depending on the herbarium administrator's validation in the RIHA platform. The automatic and periodic data transmission to gbif.org is a feature available in the IPT, and recently improved by the GBIF France team, which contributes to the IPT development. Another part of the automatic data workflow will be to feed a Living Atlases portal for the West and Central African herbaria. This web application will allow public users to search, display and download herbaria data from West and Central Africa (Fig. 4). Internally, this Living Atlases application will reuse open source modules developed by the Atlas of Living Australia (ALA). The application is mainly written in Java, uses JQuery/Bootstrap for the interface and relies on SolR and Spark in the backend. It has been developed to be easily reusable, by only modifying configuration and doing web customization (HTML / CSS), hiding most of the backend technological complexity. The automatic data workflow will transfer datasets generated by the IPT, in Darwin Core Archive format, to the Living Atlases portal backend. A technical task orchestrator, yet to be selected, will implement this feature. Living Atlases subportals, limited to data of one participating country, could be easily set up, leveraging the existing backend resources (Fig. 5). One of the benefits of the Living Atlases portal is that we can easily deploy additional front end applications with limited data, configured by a filter (here, a filter on the data owner country). Only configuration and web customization (HTML / CSS) are required. All the backend modules, especially the ones storing data, are shared by the multiple front-ends, limiting the hardware consumption and data administration. The full automation of the workflow will allow this platform to run at a very low maintenance cost for IT administrators. Moreover, adding a new herbarium member from West and Central Africa will be quite easy thanks to the architecture of the Integrated Publishing Toolkit and Living Atlases tools (Fig. 6).


2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Abdou Tenkouano ◽  
Niéyidouba Lamien ◽  
Josephine Agogbua ◽  
Delphine Amah ◽  
Rony Swennen ◽  
...  

The devastating threat of black leaf streak disease caused by Pseudocercospora fijiensis on plantain production in West Africa spurred the development of resistant hybrids. The goal of this research and development (R&D) undertaken was assessing the development and dissemination of two plantain hybrids PITA 3 and FHIA 21 bred in the 1980s by the International Institute of Tropical Agriculture (IITA, Nigeria) and the Fundación Hondureña de Investigación Agrícola (FHIA, Honduras), respectively. In Côte d’Ivoire, plantain growers selected PITA 3 and FHIA 21 based on their improved agronomic characteristics and, between 2012 and 2016, they were massively propagated and distributed to farmers in Benin, Burkina Faso, Côte d’Ivoire, and Togo under the West Africa Agricultural Productivity Program (WAAAP) coordinated by the West and Central Africa Council for Agricultural Research and Development (CORAF). In 2016, the Centre National de Recherche Agronomique in Côte d’Ivoire included the hybrids in the improved cultivar directory. This R&D activity illustrates how three decades of crossbreeding, selection, and distribution led to local acceptance. It also highlights how a CORAF-led partnership harnessed CGIAR research for development. The dissemination and acceptance of these plantain hybrids will enhance the sustainable intensification in plantain-based farming systems across the humid lowlands of West and Central Africa.


Oryx ◽  
2006 ◽  
Vol 40 (3) ◽  
pp. 355-357 ◽  
Author(s):  
Gérard Galat ◽  
Anh Galat-Luong

From 2003 to 2005 we carried out surveys in Burkina Faso to investigate the status of primate taxa. In the south-west near the border with Côte d'Ivoire we discovered sooty mangabey Cercocebus atys, a primate species that had not been previously reported in the country. This population is the subspecies C. a. lunulatus, the white-naped mangabey, one of the 25 most threatened primate taxa. As the subspecies occurs in a gallery forest that is next to a wildlife safari hunting area, we recommend that hunting is prohibited near these forests. The recent creation of the Warigué protected area, linking the Comoé-Léraba Reserved Forest and Partial Wildlife Reserve in Burkina Faso where we observed the subspecies, with the Comoé National Park in Côte d'Ivoire, could make an important contribution to the survival of this, the northernmost population, of the subspecies.


2020 ◽  
Vol 11 (1) ◽  
pp. 142
Author(s):  
Prosper Bado ◽  
Florencia Wendkuuni Djigma ◽  
Théodora Mahoukèdè Zohoncon ◽  
Dorcas Obiri-Yeboah ◽  
Esther Mah Alima Traoré ◽  
...  

Zootaxa ◽  
2021 ◽  
Vol 4948 (2) ◽  
pp. 201-220
Author(s):  
NEIL CUMBERLIDGE ◽  
PIERRE A. MVOGO NDONGO ◽  
PAUL F. CLARK

The taxonomic status of the widely distributed West and Central African freshwater crab Sudanonautes granulatus (Balss, 1929) sensu lato is revised in the light of improved morphological evidence which indicates that this taxon is a complex comprising at least 4 species: Sudanonautes granulatus (Balss, 1929) sensu stricto from Togo, S. koudougou n. sp. from Côte d’Ivoire, S. umaji n. sp. from Nigeria, and S. tiko from Cameroon, Nigeria, and Bioko. Diagnoses, illustrations and distribution maps are provided for these species and they are compared with congeners from West and Central Africa. 


2000 ◽  
Vol 23 (5) ◽  
pp. 430-436 ◽  
Author(s):  
John N. Nkengasong ◽  
Chi-Cheng Luo ◽  
Lucien Abouya ◽  
Danuta Pieniazek ◽  
Chantal Maurice ◽  
...  

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