scholarly journals Quality of Life after Total Parathyroidectomy in Patients with Secondary Hyperparathyroidism

2020 ◽  
Author(s):  
Jia Xu ◽  
ZiL Zhang ◽  
DongS Zhou ◽  
RongZ Fu ◽  
YuL Wang
Keyword(s):  
Quality Of Life ◽  
Secondary Hyperparathyroidism ◽  
Serum Calcium ◽  
Short Form ◽  
Serum Phosphorus ◽  
Definitive Treatment ◽  
Total Parathyroidectomy ◽  
Calcium Phosphorus ◽  
Stage Renal Disease

Abstract Background. Patients with end-stage renal disease (ESRD) have a decreased quality of life (QoL), which is attributable in part to secondary hyperparathyroidism (2HPT). Surgery is the definitive treatment of 2HPT. The aim of this study is to assess the effect of total parathyroidectomy with deltoid autotransplantation on the QoL. Methods: A total of 201 ESRD with 2HPT were enrolled . The operation efficacy was evaluated by analyzing preoperative and postoperative values, including levels of intact parathyroid hormone (iPTH), serum phosphorus, serum calcium, alkaline phosphatase (ALP) and calcium-phosphorus product. The QoL was evaluated by MOS 36-item short-form health survey (SF-36) scores preoperatively and at 6 months postoperation. Results: Compared with the preoperative values, levels of PTH(2033pg/ml vs 62.5 pg/ml), serum phosphorus(2.30mg/dl vs 1.60mg/dl), serum calcium(3.62mg/dl vs 1.84mg/dl), and calcium-phosphorus product were all decreased postoperative. Number variation and anatomic location variation of thyroid glands were found in the patients. Quality of life improved significantly in all 8 individual and 2 component summary scales, with a more significant decrease in the physical health scales. Conclusion: Parathyroidectomy significantly improves quality of life in patients with secondary hyperparathyroidism.

scholarly journals Quality of Life after Total Parathyroidectomy in Patients with Secondary Hyperparathyroidism

2020 ◽  
Author(s):  
JIA XU ◽  
DongS Zhou ◽  
RongZ Fu ◽  
YuL Wang
Keyword(s):  
Quality Of Life ◽  
Secondary Hyperparathyroidism ◽  
Serum Calcium ◽  
Short Form ◽  
Serum Phosphorus ◽  
Definitive Treatment ◽  
Total Parathyroidectomy ◽  
Calcium Phosphorus ◽  
Stage Renal Disease

Abstract Background. Patients with end-stage renal disease (ESRD) have a decreased quality of life (QoL), which is attributable in part to secondary hyperparathyroidism (SHPT). Surgery is the definitive treatment for SHPT. The aim of this study is to assess the effect of total parathyroidectomy (PTX) with deltoid autotransplantation on QoL.Methods: A total of 201 ESRD patients with SHPT were enrolled. The operation efficacy was evaluated by analyzing preoperative and postoperative values, including the levels of intact parathyroid hormone (PTH), serum phosphorus, serum calcium, alkaline phosphatase (ALP) and calcium-phosphorus product. The QoL was evaluated by scores on the Medical Outcomes Study 36-item short-form (SF-36) health survey preoperatively and 6 months postoperatively.Results: Compared with preoperatively, postoperatively, the levels of iPTH (2033 pg/ml vs 62.5 pg/ml), serum phosphorus (2.30 mg/dl vs 1.60 mg/dl), serum calcium (3.62 mg/dl vs 1.84 mg/dl), and calcium-phosphorus product were all decreased. Variations in the number and anatomic location of thyroid glands were found in the patients. QoL improved significantly in all 8 individual and 2 component summary scales, with a more significant decrease in the physical health scales.Conclusion: PTX significantly improves QoL in patients with SHPT.

scholarly journals Impact of Dexmedetomidine On Secondary Hyperparathyroidism Recurrence In Uremic Patients Who Received Parathyroidectomy With Auto-Transplantation: A Retrospective Propensity-Matched Study

2021 ◽  
Author(s):  
Yun Wu ◽  
Wei Han ◽  
Peikun Li ◽  
Xianwen Hu ◽  
Ye Zhang
Keyword(s):  
Quality Of Life ◽  
Propensity Score ◽  
Secondary Hyperparathyroidism ◽  
Propensity Score Matching ◽  
Mechanism Of Action ◽  
Control Group ◽  
Total Parathyroidectomy ◽  
Uremic Patients ◽  
The Difference

Abstract Background: Recurrence of secondary hyperparathyroidism (SHPT) remains a big challenge in uremic patients who underwent total parathyroidectomy with auto-transplantation (tPTX-AT). However, the relationship between perioperative intervention and recurrence of SHPT remains unclear. Dexmedetomidine has been used safely and effectively in uremic patients’ anesthesia. The aim of the study was to explore the effect of dexmedetomidine on the recurrence of SHPT and speculate the possible mechanism of action.Methods: Records of patients who underwent tPTX-AT between 2017 and 2018 were retrospectively analyzed. The study consisted of patients who received dexmedetomidine intra-operatively and the controls were patients who did not receive dexmedetomidine. The primary endpoint was the difference in the recurrence of SHPT one year after surgery between the two groups. The secondary endpoint was health-related quality of life scores. Analysis included propensity score matching and multivariable logistic regression. Results: Of 354 patients, 133 patients received dexmedetomidine intraoperatively, and the total recurrence rate of SHPT was 10.2%. After propensity score matching, patients who received dexmedetomidine had a 3.80-fold decreased risk of SHPT recurrence (odds ratio, 0.263; 95% confidence interval, 0.081 to 0.854; P=0.026) and exhibited a better quality of life in terms of physical functioning and general health, and less emotional role limitations compared with those in control group.Conclusion: In uremic patients who received tPTX-AT, there was an association between dexmedetomidine use and decreased risk of SHPT recurrence. Further studies are needed to accurately assess the effects and mechanism of action of dexmedetomidine on the prognosis of this population.

KUALITAS HIDUP PASIEN GAGAL GINJAL KRONIS YANG MENJALANI HEMODIALISIS DI RSUD CHASAN BOESOIRIE TERNATE

2019 ◽  
Vol 1 (2) ◽  
Author(s):  
FATHUL RISKY
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Short Form ◽  
Primary Data ◽  
P Value ◽  
Stage Renal Disease ◽  
End Stage

Introduction. Chronic kidney disease (CKD) as a result of structural and functional renal failure has a high progressivity leading to an end stage renal disease (ESRD), thus a therapy is needed to replace the renal function such as hemodialysis. Long term hemodialysis therapy affects many aspects of life and degrading the quality of life of the patient. Method. This cross-sectional study was conducted at Chasan Boesoirie Hospital, Ternate. Primary data, such as socio-demography were taken through history taking and medical records. Quality of life was assessed using Kidney Disease Quality of Life - Short Form (KDQOL-SF)-36 TM which has been used to measure quality of life of patients undergoing hemodialysis. Results. From this study a sample of 77 patients was obtained, of which 41 were male (53.25%) and 36 were female (46.75%). Of the three quality of life components assessed, KDCS components were 78.65 ± 13.39; the MCS component 54.67 ± 7.53; and PCS components 42.47 ± 7.76. Conclusions. From the results of the study it was found that the highest KDQOL-36TM score was obtained for the kidney disease component (KDCS), then the mental health component (MCS), and the lowest score for the physical health component (PCS). Of all the variables hypothesized to affect the quality of life of kidney failure patients undergoing hemodialis, not a single variable was found to be significantly affected (P value> 0.05).Keywords: end-stage renal disease, hemodialysis, quality of life.

Life’s quality of chronically dialyzed children in Poland

2016 ◽  
Vol 6 (2) ◽  
pp. 117-124
Author(s):  
A. Juzyszyn ◽  
D. Kunecka ◽  
B. Musiał
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Subjective Assessment ◽  
Therapeutic Education ◽  
World Health ◽  
World Health Organization Quality ◽  
Her Family ◽  
Health Organization ◽  
Stage Renal Disease

Introduction: The paper presents the possibility of assessing the quality of life (QOL) of children on dialysis. Purpose: To evaluate the QOL depending on the health status of children on dialysis, to compare the subjective assessment of the QOL and to identify some of the factors independently affecting the QOL. Materials and methods: The study has been conducted on a group of 28 children on dialysis. Research tools: Poland abbreviated version of the survey assessing the quality of life of The World Health Organization Quality of Life (WHOQOL); survey constructed on the basis of the Polish version of Kidney Disease and Quality of LifeTM Short Form (KDQOL-SFTM) Version 1.2 and a questionnaire assessing QOL of children and adolescents with end-stage renal disease on dialysis and transplantation of kidneys by Rubik, Grenda, Jakubowska - Winecka and Dabrowska. Results: There were no significant differences in QOL between children treated with peritoneal dialysis and Hemodialisis (HD). While there is a strong correlation between the severity of depressive symptoms and the treatment's duration, financial status and parents' education. Conclusions: The phenomenon of reduced QOL must be counteracted. Medical pediatric staff of dialyze centers should especially pay attention to the problem of life’s quality, due to the intensity of disease’s impact on growing organism, should actively counteract the phenomena of its decrease by continuous therapeutic education of patient and his or her family.

scholarly journals The scope of homoeopathy in improving the quality of life in patients with end-stage renal disease: A case series

2021 ◽  
Vol 4 ◽  
pp. 4-11 ◽  
Author(s):  
Mehvish Haris Dandoti ◽  
Anand Ramchandra Kapse
Keyword(s):  
Quality Of Life ◽  
Renal Failure ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Short Form ◽  
Case Series ◽  
Well Being ◽  
Stage Renal Disease ◽  
End Stage

Objectives: Lifestyle disorders such as diabetes mellitus, hypertension and cardiovascular diseases eventually affect the kidneys, often causing renal failure. The current gold standard methods for managing renal failure are renal replacement therapy and haemodialysis. Unfortunately, dialysis deteriorates the patient’s quality of life (QOL). Homoeopaths rarely treat cases with such advanced irreversible pathology; the scope of homoeopathy in such cases is, therefore, unclear. We observed the effect of homoeopathy as an adjuvant on the QOL in patients with end-stage renal disease (ESRD). The QOL was assessed using the Marathi version of the Kidney Disease QOL Short Form 1.3 (KDQOL SF version 1.3). Materials and Methods: Three Indian patients with ESRD (two men and one woman, individualized ages 38, 50 and 54 years) consented to have their data published. The cases were managed with constitutional homoeopathic remedies in the 50 millesimal (LM) potency as an adjuvant to their current allopathic medications and were observed for 6 months. They were assessed with the Marathi version of the KDQOL SF 1.3 before and after homoeopathic management along with regular haemodialysis. Results: The patients showed significant improvements in the QOL, especially in the areas of sleep, pain, symptoms and problems, cognitive functioning, emotional well-being and social functioning, as assessed based on the increase in scores in their respective domains. Conclusion: The results of the observations are promising and in concurrence with homoeopathic philosophy; the benefits of constitutional medicines were seen. All three patients showed an improvement in their QOL. However, studies with larger sample size and randomised controlled trial study design are suggested. Homoeopathic constitutional treatment has a significant impact on the QOL in patients with ESRD.

Quality of life after surgery in secondary hyperparathyroidism, comparing subtotal parathyroidectomy with total parathyroidectomy with immediate parathyroid autograft: Prospective randomized trial

Surgery ◽  
2018 ◽  
Vol 164 (5) ◽  
pp. 978-985 ◽  
Author(s):  
Wellington Alves Filho ◽  
Willemijn Y. van der Plas ◽  
Marilia D.G. Brescia ◽  
Climerio P. Nascimento ◽  
Patricia T. Goldenstein ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Secondary Hyperparathyroidism ◽  
Randomized Trial ◽  
Prospective Randomized Trial ◽  
Total Parathyroidectomy ◽  
Subtotal Parathyroidectomy

scholarly journals Predictors of early postoperative hypocalcemia in patients with secondary hyperparathyroidism undergoing total parathyroidectomy

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110150
Author(s):  
Wei Gong ◽  
Yaqi Lin ◽  
Yu Xie ◽  
Zilu Meng ◽  
Yudong Wang
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Serum Calcium ◽  
Predictive Factors ◽  
Clinical Symptoms ◽  
Total Parathyroidectomy ◽  
Postoperative Hypocalcemia ◽  
Preoperative Serum ◽  
Calcium Phosphorus ◽  
Risk Patients ◽  
Study Population

Objective To summarize the clinical features of secondary hyperparathyroidism (SHPT) in patients with chronic renal failure and to explore the predictive factors of postoperative hypocalcemia after total parathyroidectomy in these patients. Methods The clinical data of 87 patients admitted to Guangdong Electric Power Hospital from May 2013 to February 2020 were reviewed. All patients underwent total parathyroid resection and sternocleidomastoid microtransplantation. Age, sex, and the serum calcium, phosphorus, alkaline phosphatase (ALP), and intact parathyroid hormone (iPTH) concentrations were analyzed as predictive factors of postoperative hypocalcemia. Results Bone pain was the most common clinical manifestation in this study population, and all 87 patients experienced relief from their clinical symptoms after the surgical procedure. Age and the preoperative serum calcium, ALP, and iPTH concentrations were determined to be early predictive factors of postoperative hypocalcemia. Conclusions Age and the preoperative calcium, ALP, and iPTH concentrations are independent risk factors for postoperative hypocalcemia in patients with SHPT and renal disease who undergo total parathyroidectomy with sternocleidomastoid microtransplantation. These factors can help identify high-risk patients who can be managed by a multidisciplinary team to improve graft survival and quality of life.

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