scholarly journals Coverage Rate of ADME Genes: Application to CYP2C8, CYP2D6 and CYP3A Genes for Personalized Chloroquine Treatment Against Coronavirus

2020 ◽  
Author(s):  
Nabil Zaid ◽  
Loubna Khalki ◽  
Imane Hadri ◽  
Jihane Toughza ◽  
Oussama Badad ◽  
...  
Keyword(s):  
Drug Response ◽  
Statistical Data ◽  
Association Studies ◽  
Therapeutic Targets ◽  
Coverage Rate ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Chloroquine Treatment ◽  
New Therapeutic Targets

Abstract Background: The latest studies have shown the effectiveness of Chloroquine against Coronavirus. However, since the tolerance and effectiveness of statistical data must be taken into account before proposing treatment to a patient, these promising results are often lacking.Since the CYP2C8, CYP2D6 and CYP3A Absorption, Distribution, Metabolism and Elimination (ADME) genes are involved in the drug response of Chloroquine, we are interested in studying the variations of these genes.Methods: The purpose of this study is to make a comparison between the various current genotyping and enrichment platforms, to know which of them allows the best coverage. Conclusions: This will allow us to carry out genome-wide association studies (GWAS) with the aim of finding new therapeutic targets against Coronavirus using Chloroquine.

scholarly journals Informing disease modelling with brain-relevant functional genomic annotations

Brain ◽  
2019 ◽  
Vol 142 (12) ◽  
pp. 3694-3712 ◽  
Author(s):  
Regina H Reynolds ◽  
John Hardy ◽  
Mina Ryten ◽  
Sarah A Gagliano Taliun
Keyword(s):  
Genetic Association ◽  
Association Studies ◽  
Therapeutic Targets ◽  
Genome Wide Association ◽  
Disease Modelling ◽  
Genome Wide Association Studies ◽  
Functional Genomic ◽  
Genome Wide ◽  
Neuropsychiatric Diseases ◽  
Association Data

How can we best translate the success of genome-wide association studies for neurological and neuropsychiatric diseases into therapeutic targets? Reynolds et al. critically assess existing brain-relevant functional genomic annotations and the tools available for integrating such annotations with summary-level genetic association data.

scholarly journals Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine

2016 ◽  
Vol 16 (1) ◽  
pp. 70-70 ◽  
Author(s):  
Kathleen M. Giacomini ◽  
Sook Wah Yee ◽  
Taisei Mushiroda ◽  
Richard M. Weinshilboum ◽  
Mark J. Ratain ◽  
...  
Keyword(s):  
Drug Response ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Medicine ◽  
Genome Wide

scholarly journals Pharmacogenomic Determinants of Interindividual Drug Response Variability: From Discovery to Implementation

Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 393
Author(s):  
Stuart A. Scott ◽  
Jesse J. Swen
Keyword(s):  
Primary Care ◽  
Drug Response ◽  
Association Studies ◽  
Healthcare Providers ◽  
Response Variability ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Clinical Implementation ◽  
Genome Wide ◽  
Novel Variants

Since the term “pharmacogenetics” was first published in the late 1950s by Friedrich Vogel, the field has evolved into genome-wide association studies identifying novel variants associated with drug response phenotypes, international societies and consortia dedicated to pharmacogenomic research and clinical implementation, clinical practice guidelines, and the increasing availability of pharmacogenomic tests for healthcare providers in both hospital and primary care [...]

Sign in / Sign up

Export Citation Format

Share Document