scholarly journals Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies

2016 ◽  
Vol 7 ◽  
Author(s):  
Miles D. Thompson ◽  
Valerie Capra ◽  
Mark T. Clunes ◽  
G. E. Rovati ◽  
Jana Stankova ◽  
...  
2020 ◽  
Author(s):  
Nabil Zaid ◽  
Loubna Khalki ◽  
Imane Hadri ◽  
Jihane Toughza ◽  
Oussama Badad ◽  
...  

Abstract Background: The latest studies have shown the effectiveness of Chloroquine against Coronavirus. However, since the tolerance and effectiveness of statistical data must be taken into account before proposing treatment to a patient, these promising results are often lacking.Since the CYP2C8, CYP2D6 and CYP3A Absorption, Distribution, Metabolism and Elimination (ADME) genes are involved in the drug response of Chloroquine, we are interested in studying the variations of these genes.Methods: The purpose of this study is to make a comparison between the various current genotyping and enrichment platforms, to know which of them allows the best coverage. Conclusions: This will allow us to carry out genome-wide association studies (GWAS) with the aim of finding new therapeutic targets against Coronavirus using Chloroquine.


2016 ◽  
Vol 16 (1) ◽  
pp. 70-70 ◽  
Author(s):  
Kathleen M. Giacomini ◽  
Sook Wah Yee ◽  
Taisei Mushiroda ◽  
Richard M. Weinshilboum ◽  
Mark J. Ratain ◽  
...  

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Feng Guo ◽  
Xuechen Chen ◽  
Jenny Chang-Claude ◽  
Michael Hoffmeister ◽  
Hermann Brenner

Abstract Background Polygenic risk scores (PRS), which are derived from results of large genome-wide association studies, are increasingly propagated for colorectal cancer (CRC) risk stratification. The majority of studies included in the large genome-wide association studies consortia were conducted in the United States and Germany, where colonoscopy with detection and removal of polyps has been widely practiced over the last decades. We aimed to assess if and to what extent the history of colonoscopy with polypectomy may alter metrics of the predictive ability of PRS for CRC risk. Methods A PRS based on 140 single nucleotide polymorphisms was compared between 4939 CRC patients and 3797 control persons of the Darmkrebs: Chancen der Verhütung durch Screening (DACHS) study, a population-based case-control study conducted in Germany. Risk discrimination was quantified according to the history of colonoscopy and polypectomy by areas under the curves (AUCs) and their 95% confidence intervals (CIs). All statistical tests were 2-sided. Results AUCs and 95% CIs were higher among subjects without previous colonoscopy (AUC = 0.622, 95% CI = 0.606 to 0.639) than among those with previous colonoscopy and polypectomy (AUC = 0.568, 95% CI = 0.536 to 0.601; difference [Δ AUC] = 0.054, P = .004). Such differences were consistently seen in sex-specific groups (women: Δ AUC = 0.073, P = .02; men: Δ AUC = 0.046, P = .048) and age-specific groups (younger than 70 years: Δ AUC = 0.052, P = .07; 70 years or older: Δ AUC = 0.049, P = .045). Conclusions Predictive performance of PRS may be underestimated in populations with widespread use of colonoscopy. Future studies using PRS to develop CRC prediction models should carefully consider colonoscopy history to provide more accurate estimates.


Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 393
Author(s):  
Stuart A. Scott ◽  
Jesse J. Swen

Since the term “pharmacogenetics” was first published in the late 1950s by Friedrich Vogel, the field has evolved into genome-wide association studies identifying novel variants associated with drug response phenotypes, international societies and consortia dedicated to pharmacogenomic research and clinical implementation, clinical practice guidelines, and the increasing availability of pharmacogenomic tests for healthcare providers in both hospital and primary care [...]


Sign in / Sign up

Export Citation Format

Share Document