scholarly journals A Bibliometric Analysis of Folate Receptor Research

2020 ◽  
Author(s):  
Cari Didion ◽  
Walter Henne
Keyword(s):  
Bibliometric Analysis ◽  
Web Of Science ◽  
Binding Protein ◽  
Folate Receptor ◽  
Citation Rate ◽  
Time Frame ◽  
Folate Binding Protein ◽  
Average Citation ◽  
The Us ◽  
Receptor Research

Abstract Background The objective of this study is to conduct a comprehensible bibliometric analysis of the entire field of folate receptor research. Methods A Web of Science search was performed on folate receptor or folate binding protein (1969-to June 28, 2019). The following information was examined: publications per year, overall citations, top 10 authors, top 10 institutions, top 10 cited articles, top 10 countries, cc-author collaborations and key areas of research. Results In total, 3248 documents for folate receptor or folate binding protein were retrieved for the study years outlined in the methods section search query. The range was 1 per year in 1969 to 264 for the last full year studied (2018). A total of 123,720 citations for the 3,248 documents retrieved represented a mean citation rate per article of 38.09 and range of 1667 citations (range 0 to 1667). Researchers in 71 countries authored publications analyzed in this study. The US was the leader in publications and had the highest ranking institution. The top 10 articles have been cited 7270 times during the time frame of this study. The top cited article had an average citation rate of 110 citations per year. Network maps revealed considerable co-authorship among several of the top 10 authors. Conclusion Our study presents several important insights into the features and impact of folate receptor research. To our knowledge, this is the first bibliometric analysis of folate receptor.

scholarly journals A Bibliometric analysis of folate receptor research

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Cari A. Didion ◽  
Walter A. Henne
Keyword(s):  
Bibliometric Analysis ◽  
Web Of Science ◽  
Binding Protein ◽  
Folate Receptor ◽  
Citation Rate ◽  
Time Frame ◽  
Folate Binding Protein ◽  
Average Citation ◽  
The Us ◽  
Receptor Research

Abstract Background The objective of this study was to conduct a bibliometric analysis of the entire field of folate receptor research. Folate receptor is expressed on a wide variety of cancers and certain immune cells. Methods A Web of Science search was performed on folate receptor or folate binding protein (1969-to June 28, 2019). The following information was examined: publications per year, overall citations, top 10 authors, top 10 institutions, top 10 cited articles, top 10 countries, co-author collaborations and key areas of research. Results In total, 3248 documents for folate receptor or folate binding protein were retrieved for the study years outlined in the methods section search query. The range was 1 per year in 1969 to 264 for the last full year studied (2018). A total of 123,720 citations for the 3248 documents retrieved represented a mean citation rate per article of 38.09 and range of 1667 citations (range 0 to 1667). Researchers in 71 countries authored publications analyzed in this study. The US was the leader in publications and had the highest ranking institution. The top 10 articles have been cited 7270 times during the time frame of this study. The top cited article had an average citation rate of 110 citations per year. Network maps revealed considerable co-authorship among several of the top 10 authors. Conclusion Our study presents several important insights into the features and impact of folate receptor research. To our knowledge, this is the first bibliometric analysis of folate receptor.

scholarly journals A Bibliometric Analysis of Folate Receptor Research: A comprehensive bibliometric analysis of the entire field of Folate Receptor Research

2020 ◽  
Author(s):  
Cari Didion ◽  
Walter Henne
Keyword(s):  
Bibliometric Analysis ◽  
Binding Protein ◽  
Folate Receptor ◽  
Citation Rate ◽  
Time Frame ◽  
Folate Binding Protein ◽  
Entire Field ◽  
Average Citation ◽  
The Us ◽  
Receptor Research

Abstract Background The objective of this study is to conduct a comprehensible bibliometric analysis of the entire field of folate receptor research. Methods A Web of Science search was performed on folate receptor or folate binding protein (1969-to June 28, 2019). The following information was examined: publications per year, overall citations, top 10 authors, top 10 institutions, top 10 cited articles, top 10 countries, cc-author collaborations and key areas of research. Results In total, 3248 documents for folate receptor or folate binding protein were retrieved for the study years outlined in the methods section search query. The range was 1 per year in 1969 to 264 for the last full year studied (2018). A total of 123,720 citations for the 3,248 documents retrieved represented a mean citation rate per article of 38.09 and range of 1667 citations (range 0 to 1667). Researchers in 71 countries authored publications analyzed in this study. The US was the leader in publications and had the highest ranking institution. The top 10 articles have been cited 7270 times during the time frame of this study. The top cited article had an average citation rate of 110 citations per year. Network maps revealed considerable co-authorship among several of the top 10 authors. Conclusion Our study presents several important insights into the features and impact of folate receptor research. To our knowledge, this is the first bibliometric analysis of folate receptor.

scholarly journals Bibliometric Analysis Of Research on Coronavirus Infection and Patient Safety in Health Care

2021 ◽  
Vol 15 (1) ◽  
pp. 373-379
Author(s):  
Glícia Cardoso Nascimento ◽  
Gabriela Martins Santos ◽  
Samuel Ricardo Batista Moura ◽  
Ana Raquel Batista de Carvalho ◽  
Letícia da Silva Andrade ◽  
...  
Keyword(s):  
Health Care ◽  
Patient Safety ◽  
Bibliometric Analysis ◽  
Web Of Science ◽  
Time Frame ◽  
Scientific Publications ◽  
H Index ◽  
Severe Acute Respiratory Infection ◽  
Coronavirus Infection ◽  
Two Peaks

Objective: The study aimed at analyzing the international scientific publications on coronavirus infection and patient safety in health care. Methods: This research is a bibliometric study carried out by searching published articles in theISIWebofKnowledge/WebofScience database and analyzing the results through bibliometric analysis software HistCite. The selected time frame was between 1970 and 2020, and we used the following descriptors: “coronavirus infection” OR “severe acute respiratory syndrome” OR “COVID-19/SARS-CoV-2”. Results: We found 5,434 publications in 1,491 different journals; they are written by 18,274 authors linked to 4,064 institutions, which are located in 104 countries. In the citations analysis, the h-index was 155, and the average of citations each article received was 30.79. Conclusion: During the studied period, the Web of Science database showed two peaks of publications on coronavirus infections.The first comprised 768 articles published between 2003 and 2004 when a new coronavirus caused an outbreak of severe acute respiratory failure. The second consisted of 576 articles published between 2019 and 2020, during the period of the COVID-19 pandemic COVID-19. The knowledge on coronavirus infection should be widely shared so that new studies can be designed and the world scientific community can contribute to improving patient safety in healthcare and preventing new pandemics of severe acute respiratory infection caused by coronaviruses.

Characterization of a High-Affinity Folate Receptor in Normal and Malignant Human Testicular Tissue

1999 ◽  
Vol 19 (6) ◽  
pp. 571-580 ◽  
Author(s):  
Jan Holm ◽  
Steen Ingemann Hansen ◽  
Mimi Høier-Madsen ◽  
Thomas Broe Christensen ◽  
Carl W. Nichols
Keyword(s):  
Human Milk ◽  
G Protein ◽  
Radioligand Binding ◽  
Binding Protein ◽  
Folate Receptor ◽  
Testicular Tissue ◽  
Hydrophobic Membrane ◽  
Folate Binding Protein ◽  
High Affinity ◽  
Triton X

We have characterized the folate receptor in normal and malignant tissue from male gonads. Radioligand binding displayed characteristics typical of other folate receptors. Those included a high-affinity type of binding (K = 1010 M−1), apparent positive cooperativity changing into non-cooperativity at low receptor concentrations, a tendency to increased binding affinity with decreasing receptor concentrations, a slow dissociation at pH 7.4 becoming rapid at pH 3.5 and inhibition by folates, in particular oxidized forms. The gel filtration profile of Triton X-100 solubilized tissue contained a 25 and 100 kDa peak of radioligand-receptor. The latter peak could represent receptor equipped with a hydrophobic membrane anchor that inserts into Triton X-100 micelles. The concentration of radiolabelled receptor ranged from 0.41 nmol/g protein to 1.68 nmol/g protein in specimens of normal testicular tissue from patients with prostatic carcinomas and from 1.54 nmol/g protein to 3.82 nmol/g protein in testicular tissue from young individuals. Compared to normal testicular tissue the concentration of receptor in seminoma tissue was low (0.38–1.27 nmol/g protein) but showed a higher degree of immunoreactivity in the presence of antibodies against human milk folate binding protein as evidenced by ELISA and immunohistochemistry data. Hence a folate receptor isoform homologous to human milk folate binding protein is apparently expressed in seminomas where the total expression of receptor, however, seems to be lower than in normal testicles.

Role of the membrane-associated folate binding protein (folate receptor) in methotrexate transport by human KB cells

1989 ◽  
Vol 274 (2) ◽  
pp. 327-337 ◽  
Author(s):  
John C. Deutsch ◽  
Patrick C. Elwood ◽  
Raul M. Portillo ◽  
Michelle G. Macey ◽  
J.Fred Kolhouse
Keyword(s):  
Binding Protein ◽  
Folate Receptor ◽  
Kb Cells ◽  
Folate Binding Protein

scholarly journals A 10-year bibliometric analysis of osteosarcoma and cure from 2010 to 2019

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wacili Da ◽  
Zhengbo Tao ◽  
Yan Meng ◽  
Kaicheng Wen ◽  
Siming Zhou ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Bibliometric Analysis ◽  
Citation Rate ◽  
The United States ◽  
Alternative Methods ◽  
Cancer Center ◽  
Average Citation ◽  
Literature Metrology ◽  
Md Anderson ◽  
Occurrence Matrix

Abstract Background In recent decades, the 5-year survival rate of osteosarcoma remains poor, despite the variety of operations, and exploration of drug therapy has become the key to improvement. This study investigates the contribution of different aspects in osteosarcoma and cure, and predicts research hotspots to benefit future clinical outcomes. Methods The Web of Science and PubMed databases were queried to collect all relevant publications related to osteosarcoma and cure from 2009 to 2019. These data were imported into CiteSpace and the Online Analysis Platform of Literature Metrology for bibliometric analysis. Bi-clustering was performed on Bibliographic Item co-occurrence Matrix Builder (BICOMB) and gCLUTO to identify hotspots. Additionally, completed clinical trials on osteosarcoma with results past phase II were collated. Results A total of 2258 publications were identified in osteosarcoma and cure from 2009 to 2019. China has the largest number of publications (38.49%), followed by the United States (23.03%) with the greatest impact (centrality = 0.44). The centrality of most institutions is < 0.1, and Central South University and Texas MD Anderson Cancer Center possess the highest average citation rates of 3.25 and 2.87. BMC cancer has the highest average citation rate of 3.26 in 772 journals. Four authors (Picci P, Gorlick R, Bielack SS and Bacci G) made the best contributions. We also identified eight hotspots and collected 41 clinical trials related to drug research on osteosarcoma. Conclusions The urgent need exists to strengthen global academic exchanges. Overcoming multidrug resistance in osteosarcoma is the focus of past, present and future investigations. Transformation of the metastasis pattern, microenvironment genetics mechanism, alternative methods of systemic chemotherapy and exploration of traditional Chinese medicine is expected to contribute to a new upsurge of research.

scholarly journals α Isoforms of soluble and membrane-linked folate-binding protein in human blood

2008 ◽  
Vol 28 (3) ◽  
pp. 153-160 ◽  
Author(s):  
Mimi Høier-Madsen ◽  
Jan Holm ◽  
Steen I. Hansen
Keyword(s):  
Human Blood ◽  
Binding Protein ◽  
Folate Receptor ◽  
Gel Filtration ◽  
Secretory Protein ◽  
Erythrocyte Membranes ◽  
Neutrophil Granulocytes ◽  
Biological Degradation ◽  
Folate Binding Protein ◽  
Mature Neutrophil

The high-affinity FBP/FR (folate-binding protein/folate receptor) is expressed in three isoforms. FRα and FRβ are attached to cell membranes by hydrophobic GPI (glycosylphosphatidylinositol) anchors, whereas FBPγ is a secretory protein. Mature neutrophil granulocytes contain a non-functional FRβ on the surface, and, in addition, nanomolar concentrations of a secretory functional FBP (29 kDa) can be present in the secondary granules. A statistically significant correlation between the concentrations of functional FBP, probably a γ isoform, in granulocytes and serum supported the hypothesis that serum FBP (29 kDa) mainly originates from neutrophils. The presence of FBP/FRα isoforms were established for the first time in human blood using antibodies specifically directed against human milk FBPα. The α isoforms identified on erythrocyte membranes, and in granulocytes and serum, only constituted an almost undetectable fraction of the functional FBP. The FBPα in neutrophil granulocytes was identified as a cytoplasmic component by indirect immunofluorescence. Gel filtration of serum revealed a peak of FBPα (>120 kDa), which could represent receptor fragments from decomposed erythrocytes and granulocytes. The soluble FBPs may exert bacteriostatic effects and protect folates in plasma from biological degradation, whereas FRs on the surface of blood cells could be involved in intracellular folate uptake or serve as signal proteins. The latter receptors have also been used for therapeutic targeting in malignancy.

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