scholarly journals Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with systemic sclerosis

2021 ◽  
Author(s):  
Cecilia Tito ◽  
Juliana Silvatti ◽  
Izabela N. F. Almeida ◽  
Elise V. Taniguchi ◽  
Tiago Prata ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Systemic Sclerosis ◽  
Ganglion Cell ◽  
Disease Duration ◽  
Optical Coherence ◽  
Swept Source ◽  
Rnfl Thickness ◽  
Structural Abnormalities ◽  
Digital Blood Flow

Abstract PurposeVasospasm represents an early event in systemic sclerosis (SSc). Ocular vasospasm may induce optic nerve head (ONH) damage and has been involved in the pathogenesis of glaucoma, especially normal-tension glaucoma (NTG). We aimed to investigate the presence of structural abnormalities associated with NTG using swept-source optical coherence tomography (SS-OCT) and to correlate the OCT parameters with clinical, capillaroscopy and digital blood flow measures in patients with SSc. MethodsIn this cross-sectional study, 40 patients with SSc and 23 age-matched controls were included. The following parameters were measured using SS-OCT: mean and sectoral retinal nerve fiber layer (RNFL) thickness, macular ganglion cell layer complex (GCC) thickness and ONH morphology. Nailfold capillaroscopy (NFC) and digital blood flow measurements using laser Doppler imaging (LDI) were performed in all subjects. ResultsPatients with SSc showed a thinner temporal RNFL than the controls (69.23 ± 11.74 versus 83.35 ± 20.19 µm, p=0.001). The other parameters were similar between the two groups. In SSc patients, there was an inverse correlation between the disease duration and the average, superior and inferior RNFL thickness and the GCC thickness and between Raynaud’s phenomenon duration and the average RNFL and GCC thickness (p<0.05). NFC and LDI measurements did not show correlations with OCT parameters.ConclusionA thinner temporal RNFL and the correlation between Raynaud’s phenomenon and disease duration and structural abnormalities on OCT suggest the presence of early ganglion cell damage in patients with SSc. Although mild, these findings indicate the need to monitor ocular abnormalities in SSc.

scholarly journals Structural abnormalities associated with glaucoma using swept-source optical coherence tomography in patients with systemic sclerosis

2021 ◽  
Author(s):  
Cecilia Victoria Agapito Tito ◽  
Juliana Silvatti ◽  
Izabela N. F. de Almeida ◽  
Elise V. Taniguchi ◽  
Tiago S. Prata ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Systemic Sclerosis ◽  
Optical Coherence ◽  
Swept Source ◽  
Structural Abnormalities

scholarly journals Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Elena Garcia-Martin ◽  
Laura Jarauta ◽  
Elisa Vilades ◽  
Jose Ramon Ara ◽  
Jesus Martin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Optical Coherence ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Swept Source ◽  
Rnfl Thickness ◽  
Depth Analysis ◽  
Retinal Thinning

Purpose. To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS). Methods. A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Triton OCT (Topcon). Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluation. Results. Significant macular thinning was observed in all ETDRS areas (p<0.001) in MS patients. Peripapillary retinal, RNFL, and GCL ++ thickness showed a significant reduction in patients in all sectors (p<0.001) except in the nasal quadrant/sector (p>0.05). GCL+ measurements were found to be reduced in the nasal (p=0.003), inferonasal (p=0.045), and temporal (p=0.001) sectors and total thickness (p<0.001). Choroidal thickness was reduced in the outer macular ring in MS patients compared with controls (p=0.038). Conclusion. New swept-source technology for OCT devices detects retinal thinning in MS patients, providing increased depth analysis of the choroid in these patients. MS patients present reduced retinal and choroidal thickness in the macular area and reduced peripapillary retinal, RNFL, and GCL thickness.

scholarly journals Determination of Referential Rates for Optical Coherence Tomography and Optical Coherence Tomography Angiography Flow Deficits in the Macular Choriocapillaris in Ophthalmologically Healthy Children

Medicina ◽  
2020 ◽  
Vol 56 (5) ◽  
pp. 238
Author(s):  
Viktorija Bakstytė ◽  
Liveta Šniurevičiūtė ◽  
Evelina Šimienė ◽  
Justina Skruodytė ◽  
Ingrida Janulevičienė
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Healthy Children ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Swept Source ◽  
Rnfl Thickness ◽  
Swept Source Oct ◽  
New Research

Background and Objectives: Despite the growing number of new research publications, normative references for children’s optical coherence tomography (OCT) parameters are still not completed. We chose to explore this topic because of the lack of normative parameters that is due to an improvement in different technologies and instruments. Our aim was to determine referential rates of retinal nerve fiber layer (RNFL) thickness and flow deficits (FD%) in the macular choriocapillaris (CC) in normal eyes of ophthalmologically healthy children. Materials and Methods: Ophthalmologically healthy 8- to 14-year-old individuals participated (n = 75) in this study. OCT images were taken using an swept-source-OCT (SS-OCT) instrument (DRI-OCT Triton, Topcon, Tokyo, Japan). The early treatment diabetic retinopathy study (EDTRS) grid (6 × 6 mm) divided the RNFL into the thickness maps. The FD% values of the CC were calculated on the 3 × 3-mm scans in a 1-mm circle (C1), 1.5-mm rim (R1.5), and the entire 2.5-mm circle (C2.5), and on the 6 x 6-mm scans in a 1-mm circle (C1), 1.5-mm rim (R1.5), the entire 2.5-mm circle (C2.5), 2.5-mm rim (R2.5), and 5-mm circle (C5). Results: Both scan quantifications of FD% in the C1, C2.5, and R1.5 sectors were similar, but the 6 × 6-mm scan measurements were statistically significantly smaller than the 3 × 3-mm ones. Significant moderate correlations were found between axial length (AxL) and FD% in the 6 × 6-mm scans, namely C1 (r = −0.347, p = 0.002), C2.5 (r = −0.337, p = 0.003), R1.5 (r = −0.328, p = 0.004), R2.5 (r = −0.306, p = 0.008), and C5 (r = −0.314, p = 0.006). Conclusions: The thinnest RNFL layers were on the temporal and nasal sides. FD% values in the C1, C2.5, and R1.5 sectors were similar between the 3 × 3-mm and 6 × 6-mm scans. The negative moderate correlations between AxL and FD% were found in all C1, C2.5, C5, R1.5, and R2.5 sectors of the 6 × 6-mm scans. Further prospective studies are needed to determine more accurate normative references for children’s OCT parameters.

scholarly journals Correlation of retinal and choroidal microvascular impairment in systemic sclerosis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Felix Rommel ◽  
David Prangel ◽  
Michelle Prasuhn ◽  
Salvatore Grisanti ◽  
Mahdy Ranjbar
Keyword(s):  
Optical Coherence Tomography ◽  
Systemic Sclerosis ◽  
Optical Coherence Tomography Angiography ◽  
Clinical Evidence ◽  
Disease Duration ◽  
Cross Sectional Study ◽  
Ocular Involvement ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Choroidal Perfusion

Abstract Purpose To investigate the correlation between retinal and choroidal microperfusion in patients with systemic sclerosis (SSc) using optical coherence tomography angiography (OCTA). Methods In this cross-sectional study SSc patients without clinical evidence of ocular involvement and healthy, age- and sex-matched volunteers were recruited. Participants underwent specific rheumatological and ophthalmological examinations, including optical coherence tomography (OCT) and OCTA. Retinal and choroidal thicknesses as well as perfusion of the retina and the choroidal sublayers were evaluated. Results A total of 15 SSc patients (30 eyes) with a median disease duration of 60 months and 15 matched, healthy controls (30 eyes) were recruited. OCT data revealed a significantly lower macular volume, as well as Sattler’s layer and Haller’s layer thickness in SSc patients compared to controls. In OCTA analysis, the perfusion of both retinal plexus as well as Sattler’s and Haller’s layer were significantly reduced in the SSc group. Patients with a disease duration of more than 60 months showed a statistically significant positive correlation between retinal and choroidal malperfusion, while those with a shorter disease duration did not. Conclusion OCTA analysis confirmed impairment of retinal and choroidal microperfusion in SSc patients, supporting the hypothesis of wide spreading vascular injury. In early stages, either the retinal or the choroidal perfusion seems to be involved, while later on, vascular impairment affects both tissues alike. Both, retinal and choroidal examinations should be considered as soon as the diagnosis of SSc is made, to avoid missing out on early alterations.

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