scholarly journals Association Of Multispecific Red Blood Cell Alloimmunization With HLA-Class II Variants is Related to Mjor RhD Phenotypes

2020 ◽  
Author(s):  
Alena Maluskova ◽  
Frantisek Mrazek ◽  
Renata Kozelska ◽  
Martin Koristka ◽  
Zuzana Cermakova
Keyword(s):  
General Population ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Class Ii ◽  
Hla Class Ii ◽  
Transplant Recipients ◽  
Hla Phenotype ◽  
Hla Dqa1 ◽  
The Relationship ◽  
Negative Phenotype

Abstract Background It remains unclear why only some patients form alloantibodies against foreign RBC antigens. Transfusion of red blood cell (RBC) products and pregnancy are the most relevant causes of immunization against RBC alloantigens. Here we investigated the relationship between RBC alloantibodies, Rh phenotype, and HLA phenotype among patients with multiple RBC alloantibodies Methods In a group of 124 multi-responders—including both pregnant women and transplant recipients—we analyzed the distribution of HLA-Class II variants in subgroups of multi-responders to RBC alloantigens according to their Rh status. Results As expected, the RhD-negative phenotype was overrepresented in our alloimmunized group (49.2%) compared to in the general population. Importantly, HLA-DRB1*15 carriers were significantly overrepresented among D-negative multi-responders compared to D-positive multi-responders (Pc = 0.045). Furthermore, the linked HLA-DRB1*13, HLA-DQB1*06, and HLA-DQA1*01 variants were more frequent in individuals with the DCCee phenotype than in other RhD-positive phenotypes. Conclusion Our present findings showed that RBC multispecific alloimmunization was associated with particular HLA-Class II variants based on Rh status.

scholarly journals Association of multispecific red blood cell alloimmunization with HLA-Class II variants is related to Rh phenotypes

2021 ◽  
Vol 122 (03) ◽  
pp. 179-183
Author(s):  
A. Maluskova ◽  
F. Mrazek ◽  
R. Kozelska ◽  
M. Koristka ◽  
Z. Cermakova
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Class Ii ◽  
Hla Class Ii

MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciprum

1992 ◽  
Vol 4 (9) ◽  
pp. 1055-1063 ◽  
Author(s):  
E. M. Riley ◽  
O. Olerup ◽  
S. Bennett ◽  
P. Rowe ◽  
S. J. Allen ◽  
...  
Keyword(s):  
Immune Responses ◽  
Class Ii ◽  
Hla Class Ii ◽  
The Relationship ◽  
Hla Class Ii Alleles

scholarly journals Effect of red blood cell transfusion on short-term outcomes in very low birth weight infants

2020 ◽  
Vol 63 (2) ◽  
pp. 56-62
Author(s):  
Eui Young Lee ◽  
Sung Shin Kim ◽  
Ga Young Park ◽  
Sun Hyang Lee
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Very Low Birth Weight ◽  
Short Term ◽  
Vlbw Infants ◽  
Early Onset Sepsis ◽  
The Relationship ◽  
Rbc Transfusion

Background: Red blood cell (RBC) transfusion improves cardiorespiratory status of preterm infants by increasing circulating hemoglobin, improving tissue oxygenation, and reducing cardiac output. However, RBC transfusion itself has also been suggested to negatively affect short-term outcomes such as intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), and necrotizing enterocolitis (NEC) in premature infants.Purpose: This study aimed to analyze the relationship between RBC transfusion and short-term outcomes in very low birth weight (VLBW) infants (birth weight, <1,500 g).Methods: We retrospectively reviewed the medical records of VLBW infants admitted to the Soonchunhyang University Bucheon Hospital between October 2010 and December 2017. Infants who died during hospitalization were excluded. The infants were divided into 2 groups according to RBC transfusion status. We investigated the relationship between RBC transfusion and short-term outcomes including BPD, ROP, NEC, and IVH.Results: Of the 250 enrolled VLBW infants, 109 (43.6%) underwent transfusion. Univariate analysis revealed that all shortterm outcomes except early-onset sepsis and patent ductus arteriosus were associated with RBC transfusion. In multivariate analysis adjusted for gestational age, birth weight and Apgar score at 1 minute, RBC transfusion was significantly correlated with BPD (odds ratio [OR], 5.42; <i>P</i><0.001) and NEC (OR, 3.40; <i>P</i>= 0.009).Conclusion: RBC transfusion is significantly associated with adverse clinical outcomes such as NEC and BPD in VLBW infants. Careful consideration of the patient’s clinical condition and appropriate guidelines is required before administration of RBC transfusions.

scholarly journals Multiple Sclerosis in French Canadians: Evidence for HLA Class II Susceptibility and Resistance Genes

1990 ◽  
Vol 17 (4) ◽  
pp. 382-386 ◽  
Author(s):  
D.G. Haegert ◽  
M. Michaud ◽  
G.S. Francis
Keyword(s):  
Multiple Sclerosis ◽  
Resistance Genes ◽  
Rflp Analysis ◽  
Class Ii ◽  
Hla Class Ii ◽  
Extended Haplotype ◽  
Allele Specific ◽  
Relationship Of ◽  
The Relationship ◽  
Susceptibility And Resistance

ABSTRACT:HLA class II DRBI, DQB1 and DQA1 gene probes were used to study DNA from unrelated French Canadian multiple sclerosis (MS) patients and controls by restriction fragment length polymorphism (RFLP) analysis. An MS-associated and linked series of allele-specific RFLPs or allogenotypes was identified among this relatively homogeneous ethnic group; the allogenotypes include DRwl5, DQw6 and a DQA1 allogenotype termed DQαlb. An additional allogenotype which cross-hybridizes with DQA1 and is termed DQA2 upper (DQA2U), was shown not only to be part of the MS-associated extended haplotype, but also to be independently associated with MS in DRwl5-negative patients. Conversely a second DQA2 allogenotype, termed DQA2 lower (DQA2L) and a DQB1 allogenotype (DQw7) linked to DQA2L showed negative correlations with MS. It seems likely that the relationship of the HLA class II gene region to MS is complex and that MS susceptibility may reflect interaction between disease susceptibility and resistance genes.

SOLUBLE HLA CLASS II CONCENTRATIONS IN NORMAL INDIVIDUALS AND TRANSPLANT RECIPIENTS

1994 ◽  
Vol 58 (11) ◽  
pp. 1268-1272 ◽  
Author(s):  
JOHN C. MCDONALD ◽  
IRENA ADAMASHVILI ◽  
J. MARTIN HAYES ◽  
DONNIE F. AULTMAN ◽  
V. KEITH RHYNES ◽  
...  
Keyword(s):  
Class Ii ◽  
Hla Class Ii ◽  
Transplant Recipients ◽  
Normal Individuals ◽  
Soluble Hla

scholarly journals Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition

2020 ◽  
pp. neurintsurg-2020-016966
Author(s):  
Seán Fitzgerald ◽  
Rosanna Rossi ◽  
Oana Madalina Mereuta ◽  
Duaa Jabrah ◽  
Adaobi Okolo ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Formation Mechanisms ◽  
Large Artery ◽  
Cell Content ◽  
Stroke Etiology ◽  
Clot Burden ◽  
Similar Formation ◽  
The Relationship ◽  
Radiological Studies

BackgroundInitial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic strokes are associated with shorter clot lengths and lower clot burden than non-cardioembolic clots.ObjectiveTo report the relationship between stroke etiology, extracted clot area, and histological composition at each procedural pass.MethodsAs part of the multi-institutional RESTORE Registry, the Martius Scarlett Blue stained histological composition and extracted clot area of 612 per-pass clots retrieved from 441 patients during mechanical thrombectomy procedures were quantified. Correlations with clinical and procedural details were investigated.ResultsClot composition varied significantly with procedural passes; clots retrieved in earlier passes had higher red blood cell content (H4=11.644, p=0.020) and larger extracted clot area (H4=10.730, p=0.030). Later passes were associated with significantly higher fibrin (H4=12.935, p=0.012) and platelets/other (H4=15.977, p=0.003) content and smaller extracted clot area. Large artery atherosclerotic (LAA) clots were significantly larger in the extracted clot area and more red blood cell-rich than other etiologies in passes 1–3. Cardioembolic and cryptogenic clots had similar histological composition and extracted clot area across all procedural passes.ConclusionLAA clots are larger and associated with a large red blood cell-rich extracted clot area, suggesting soft thrombus material. Cardioembolic clots are smaller in the extracted clot area, consistent in composition and area across passes, and have higher fibrin and platelets/other content than LAA clots, making them stiffer clots. The per-pass histological composition and extracted clot area of cryptogenic clots are similar to those of cardioembolic clots, suggesting similar formation mechanisms.

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