scholarly journals The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon

2021 ◽  
Author(s):  
Gonul Aciksari ◽  
Gokhan CETINKAL ◽  
Mehmet KOCAK ◽  
Adem Atici ◽  
Fatma Betul Celik ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Slow Flow ◽  
Flow Phenomenon ◽  
Coronary Slow Flow ◽  
Coronary Slow Flow Phenomenon ◽  
The Relationship

Abstract Purpose: In this study, we aimed to investigate the relationship between high triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and coronary slow-flow phenomenon (CSFP) in patients undergoing elective coronary angiography for suspected coronary artery disease. Methods: This prospective study included a total of 84 CSFP patients and 83 controls with normal coronary flow, as evidenced by coronary angiography. The Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) was used to measure the coronary blood flow velocity. The lipid profiles were analyzed and TG/HDL-C ratio were calculated dividing absolute TG levels by absolute HDL-C levels in peripheral blood. Results: The median TG/HDL-C ratio was higher in the CSFP group than the control group (3.4 [2.6 to 4.9] vs. 2.3 [1.8 to 3], respectively; p<0.001). The multivariate logistic regression analysis revealed that TG/HDL-C ratio was an independent predictor of CSFP (odds ratio [OR]: 1.78, 95% confidence interval [CI]: 1.59-2.32; p=0.001) and TG/HDL-C ratio was positively correlated with the TFC in the CSFP group ( r =0.311, p<0.001). The area under the receiver operating characteristic curve of TG/HDL-C for the diagnosis of CSFP was 0.73 (95% CI: 0.65-0.81; p<0.001). If a cut-off value of 2.75 was used, higher levels of TG/HDL-C ratio could predict the presence of CSFP with 72% sensitivity and 71% specificity. Conclusion: Our study results suggest that TG/HDL-C ratio is associated with CSFP and may be a useful biomarker for predicting CSFP and its severity.

scholarly journals The relationship between high-density lipoprotein cholesterol and vasomotor function

2003 ◽  
Vol 41 (6) ◽  
pp. 238
Author(s):  
Jeffrey T. Kuvin ◽  
Ayan R. Patel ◽  
Mandeep Sidhu ◽  
William M. Rand ◽  
Kathleen A. Sliney ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Vasomotor Function ◽  
The Relationship

scholarly journals High-Density Lipoprotein Cholesterol in Young Nondiabetic Coronary Heart Disease Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Ziyang Hu ◽  
Jingle Cui ◽  
Xueshan Li ◽  
Yaohui Zhou ◽  
Lu Cai ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Normal Group ◽  
Lipoprotein Cholesterol

Objective. To investigate the association between the lipid profiles and coronary heart disease (CHD) in nondiabetic patients younger than 65 years of age. Method. 424 patients were enrolled in this study from January 2019 to December 2020. All the patients were screened for clinically indicated coronary angiography. They were divided into two groups according to the coronary angiography results: 340 patients with the presence of CHD (at least one coronary artery stenosis ≥50%) were classified as the CHD group, and the rest with the absence of CHD comprised the normal group. The demographic data and lipid profiles were compared. Result. CHD was higher in males than females (84.5% vs. 62.2%, P < 0.001 ). In the CHD group, the level of high‐density lipoprotein cholesterol (HDL-C) was lower P < 0.001 , while the triglyceride (TG)/HDL-C ratio was higher P = 0.022 . No significant differences were shown between the two groups in terms of age, family history of CHD, hypertension, and the levels of TC, TG, and LDL-C. Gender differences were further explored. In men, except for the level of HDL-C which was significantly lower in the CHD group than that in the normal group P = 0.017 , parameters were comparable. A binary logistic regression model further indicated that HDL-C was associated with CHD (OR = 0.137, 95%CI: 0.031–0.594, P = 0.008 ). Also, with the increase of the number of coronary artery with lesions, the levels of HDL-C decreased significantly in men. In women, no differences were observed between the CHD group and normal group. Conclusion. HDL-C may be inversely associated with the risk of CHD in young nondiabetes patients, especially in men. More research is needed to confirm it.

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