scholarly journals Debulking mastectomy with electrochemotherapy: a case report of no surgery approach to recurrent breast cancer.

2020 ◽  
Author(s):  
Emanuela Esposito ◽  
Claudio Siani ◽  
Ugo Pace ◽  
Raffaele Costanzo ◽  
Raimondo di Giacomo
Keyword(s):  
Breast Cancer ◽  
Chest Wall ◽  
New Technologies ◽  
Cancer Recurrence ◽  
Recurrent Breast Cancer ◽  
Breast Conserving Surgery ◽  
Breast Cancer Recurrence ◽  
Multi Drug Resistance ◽  
Patient Will ◽  
Recurrent Breast

Abstract Background Electrochemotherapy has been shown to be safe, effective and non-invasive loco-regional treatment for chest wall breast cancer recurrence. Electrochemotherapy is the gold standard treatment of patients with cutaneous metastases from breast cancer who due to the extent of those lesions are not eligible for resection or radiotherapy has already been used, and systemic therapy is ineffective or contraindicated. Case presentation Here we present the case of a women affected by multiple metastatic cancers with multi-drug resistance who refused mastectomy after being diagnosed with recurrent ulcerated right breast cancer. We first describe an extended indication to electrochemotherapy to treat breast cancer recurrence after breast conserving surgery. Electroporation-induced necrosis through electrochemotherapy replaced surgery and was delivered in 30 minutes at 5000 Hz frequencies at 730 V by hexagonal needle under general anesthesia. The necrosis of the remaining breast resulted in a voluminous eschar that was easily removed few months after leaving the chest wall free from macroscopic disease turning in a non-surgical mastectomy. Conclusions. This kind of breakthrough application of electrochemotherapy might be considered to avoid palliative mastectomy in very selected patients. New technologies may help clinicians to find agreement between patient’ will and the burden of treatment and might contribute in selected cases to give options to patients not keen on having surgery.

scholarly journals Proteomic Analysis of Inflammatory Biomarkers Associated With Breast Cancer Recurrence

2020 ◽  
Vol 185 (Supplement_1) ◽  
pp. 669-675 ◽  
Author(s):  
Alakesh Bera ◽  
Eric Russ ◽  
Muthu Srinivasan ◽  
Ofer Eidelman ◽  
Michael Eklund ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Imaging ◽  
Critical Role ◽  
Embryonic Stem ◽  
Cancer Recurrence ◽  
Recurrent Breast Cancer ◽  
Breast Cancer Recurrence ◽  
Breast Cancer Patients ◽  
Recurrent Breast

ABSTRACT Introduction Breast cancer is the most frequent cancer detected for women, and while our ability to treat breast cancer has improved substantially over the years, recurrence remains a major obstacle. Standard screening for new and recurrent breast cancer involves clinical breast imaging. However, there is no clinically approved noninvasive body fluid test for the early detection of recurrent breast cancer. Materials and Method: In this study, we analyzed serum samples from both recurrent and nonrecurrent breast cancer patients by different proteomics methods to identify biomarkers in patients with recurrence of disease. Results Comparative data analysis identified several histone deacetylase (HDAC) proteins, which were found at significantly higher levels in the serum of recurrent breast cancer patients: HDAC9 (C-term) (P = 0.0035), HDAC5 (C-term) (P = 0.013), small ubiquitin-like modifier 1 (N-term) (P = 0.017), embryonic stem cell-expressed Ras (inter) (P = 0.018), and HDAC7 (C-term) (P = 0.020). Chronic inflammation plays a critical role in the development of the breast cancer recurrence, and we identified several proinflammatory cytokines that were present at elevated levels only in recurrent breast cancer patient serum. Conclusions Our data indicated that the epigenetic regulation of inflammatory processes plays a critical role in breast cancer recurrence. The identified proteins could lay the groundwork for the development of a serum-based breast cancer recurrence assay.

scholarly journals Imaging Surveillance of the Reconstructed Breast in a Subset of Patients May Aid in Early Detection of Breast Cancer Recurrence

2021 ◽  
Vol 11 ◽  
pp. 58
Author(s):  
Beatriz Elena Adrada ◽  
Niloofar Karbasian ◽  
Monica Huang ◽  
Gaiane Maia Rauch ◽  
Piyanoot Woodtichartpreecha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Detection Method ◽  
Cancer Recurrence ◽  
Recurrent Breast Cancer ◽  
Breast Cancer Recurrence ◽  
Imaging Features ◽  
Imaging Surveillance ◽  
Recurrent Breast ◽  
Reconstructed Breast

Objectives: The purpose of this study is to determine the biological markers more frequently associated with recurrence in the reconstructed breast, to evaluate the detection method, and to correlate recurrent breast cancers with the detection method. Material and Methods: An institutional review board-approved retrospective study was conducted at a single institution on 131 patients treated with mastectomy for primary breast cancer followed by breast reconstruction between 2005 and 2012. Imaging features were correlated with clinical and pathologic findings. Results: Of the 131 patients who met our inclusion criteria, 40 patients presented with breast cancer recurrence. The most common histopathologic type of primary breast cancer was invasive ductal carcinoma in 82.5% (33/40) of patients. Triple-negative breast cancer was the most common biological marker with 42.1% (16/38) of cases. Clinically, 70% (28/40) of the recurrences presented as palpable abnormalities. Of nine patients who underwent mammography, a mass was seen in eight patients. Of the 35 patients who underwent ultrasound evaluation, an irregular mass was found in 48.6% (17/35) of patients. Nine patients with recurrent breast cancer underwent breast MRI, and MRI showed an irregular enhancing mass in four patients, an oval mass in four patients, and skin and trabecular thickening in one patient. About 55% of patients with recurrent breast cancer were found to have distant metastases. Conclusion: Patients at higher risk for locoregional recurrence may benefit from imaging surveillance in order to detect early local recurrences.

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