scholarly journals Do alternative capability instruments capture differing aspects of mental health and quality of life in comparison to the EQ-5D for schizophrenic patients with depression?

2020 ◽  
Author(s):  
Timea Mariann Helter ◽  
Joanna Coast ◽  
Agata Łaszewska ◽  
Tanja Stamm ◽  
Judit Simon
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Health Research ◽  
Convergent Validity ◽  
Mental Health Research ◽  
Change Scores ◽  
Health Related ◽  
Schizophrenic Patients ◽  
Descriptive System

Abstract Background: There is increasing evidence that assessing outcomes in terms of capability wellbeing provides information beyond that of health-related quality of life measures for evaluation in mental health research. This paper aimed to contribute to the utilisation of capability-based measures relative to health status measures in mental health research, by exploring the empirical relationship between the OxCAP-MH, the ICECAP-A, and the EQ-5D instruments against condition-specific measures and each other for schizophrenic patients with depression. Methods: Using trial data for 100 patients from the UK, the properties of the instruments were compared in terms of convergent validity, including correlations between the OxCAP-MH, the ICECAP-A, the EQ-5D-5L descriptive system and the EQ-5D VAS scores; and a line of central tendency between two variables was plotted on locally weighted smoothing curves. Exploratory factor analysis (EFA) investigated the extent to which the instruments measured complementary or overlapping constructs. Responsiveness was assessed in terms of standardised response mean and correlation between change scores (baseline to endpoint) of the instruments. Results: Correlation between the OxCAP-MH and ICECAP-A baseline scores was strong (0.682) and between change scores was moderate (0.401). The baseline scores of both capability instruments correlated more with condition-specific (0.481-0.718) than with generic (0.344-0.425) instruments. Their change scores weakly correlated with change scores of the generic health-related scales (0.183-0.247), but moderately with those of condition-specific instruments (0.339-0.557). The EFA found that while the EQ-5D-5L descriptive system loaded onto one factor, the items of the ICECAP-A loaded onto two additional factors and the items of the OxCAP-MH loaded onto three additional factors. Conclusions: The capability instruments had stronger convergent validity with each other than with any of the other instruments. Assessing outcomes in terms of capabilities for schizophrenic patients with depression proved to capture broader relevant information than the EQ-5D-5L both by the OxCAP-MH and the ICECAP-A, albeit to different extent. When comparing the two capability instruments, the OxCAP-MH tended to have stronger correlations with condition-specific instruments most likely due to its origin from mental health outcome measurement, while the ICECAP-A had slightly stronger correlation with the EQ-5D VAS.

scholarly journals Do alternative capability instruments capture differing aspects of mental health and quality of life in comparison to the EQ-5D for schizophrenic patients with depression?

2021 ◽  
Author(s):  
Timea Mariann Helter ◽  
Joanna Coast ◽  
Agata Łaszewska ◽  
Tanja Stamm ◽  
Judit Simon
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Health Research ◽  
Convergent Validity ◽  
Mental Health Research ◽  
Change Scores ◽  
Health Related ◽  
Schizophrenic Patients ◽  
Eq Vas

Abstract Background There is increasing evidence that assessing outcomes in terms of capability wellbeing provides information beyond that of health-related quality of life measures for evaluation in mental health research. This paper aimed to contribute to the utilisation of capability-based measures relative to health status measures in mental health research, by exploring the empirical relationship between the OxCAP-MH, the ICECAP-A, and the EQ-5D instruments against condition-specific measures and each other for schizophrenic patients with depression.Methods Using trial data for 100 patients from the UK, the properties of the instruments were compared in terms of convergent validity, including correlations between the OxCAP-MH, the ICECAP-A, the EQ-5D-5L and the EQ VAS scores; and a line of central tendency between two variables was plotted on locally weighted smoothing curves. Exploratory factor analysis (EFA) investigated the extent to which the instruments measured complementary or overlapping constructs. Responsiveness was assessed in terms of standardised response mean and correlation between change scores (baseline to endpoint) of the instruments. Results Correlation between the OxCAP-MH and ICECAP-A baseline scores was strong (0.677) and between change scores was moderate (0.388). The baseline scores of both capability instruments correlated more with condition-specific (0.481-0.718) than with generic (0.354-0.431) instruments. Change scores of the capability instruments weakly correlated with change scores of the generic health-related scales (0.131-0.269), but moderately with those of condition-specific instruments for the ICECAP-A (0.355-0.451) and moderately/strongly for the OxCAP-MH (0.437-0.557). The EFA found that while the EQ-5D-5L loaded onto one factor, the items of the ICECAP-A loaded onto two additional factors and the items of the OxCAP-MH loaded onto three additional factors. Conclusions The capability instruments had stronger convergent validity with each other than with any of the other instruments. Assessing outcomes in terms of capabilities for schizophrenic patients with depression proved to capture broader relevant information than the EQ-5D-5L both by the OxCAP-MH and the ICECAP-A, albeit to different extents. When comparing the two capability instruments, the OxCAP-MH tended to have stronger correlations with condition-specific instruments most likely due to its origin from mental health outcome measurement, while the ICECAP-A had slightly stronger correlation with the EQ VAS. These capability measures provide a viable option for measuring outcome for economic evaluations of severe mental health conditions, and we would recommend the inclusion of OxCAP-MH and/or ICECAP-A alongside generic instruments such as the EQ-5D so that further evidence can be obtained.

Does Assessing Outcomes in Terms of Capability for Schizophrenic Patients with Depression Provide more Information Than use of the NICE Recommended QALY? - An Empirical Comparison of the OxCAP-MH, ICECAP-A and EQ-5D-5L Instruments

2020 ◽  
Author(s):  
Timea Mariann Helter ◽  
Joanna Coast ◽  
Agata Łaszewska ◽  
Tanja Stamm ◽  
Judit Simon
Keyword(s):  
Mental Health ◽  
Construct Validity ◽  
Convergent Validity ◽  
Mental Health Research ◽  
Future Research ◽  
Change Scores ◽  
Health Related ◽  
Schizophrenic Patients ◽  
Descriptive System ◽  
Disease Specific

Abstract BackgroundThere is increasing evidence that assessing outcomes in terms of capability wellbeing provides information beyond that of health-related quality of life measures for evaluation in mental health research. This paper aims to comprehensively compare the properties of the Oxford CAPabilities questionnaire-Mental Health (OxCAP-MH), the ICECAP-A the EQ-5D-5L descriptive system and EQ-5D VAS in schizophrenic patients with depression.Methods Using trial data for 100 patients from the UK, the properties of the instruments were compared in terms of construct validity, including correlations between the OxCAP-MH, the ICECAP-A, the EQ-5D-5L descriptive system and the EQ-5D VAS scores; and comparative assessment of their sensitivity to change based on external anchors. Exploratory factor analysis (EFA) investigated the extent to which the instruments measure complementary or overlapping constructs. The pattern and extent of agreement between all instruments was plotted on Bland-Altman diagrams. ResultsDifferent aspects of the analysis confirmed that the capability instruments had stronger convergent validity with each other than with health-related instruments. The EFA found that while the EQ-5D-5L descriptive system loads onto one factor, the items of the ICECAP-A load onto three factors and the items of the OxCAP-MH spread across four factors. Correlation between the OxCAP-MH and ICECAP-A change scores was moderate (0.389). The ICECAP-A change scores also moderately correlated with change scores of generic health-related scales (0.307-0.357) and disease-specific instruments (0.295-0.468). The OxCAP-MH change scores had low correlation to generic (0.153-0.202) and moderate to high correlation with disease-specific instruments (0.441-0.527). The Bland Altman plots showed small average discrepancy between the four scales. However, the limits of agreement were wider and therefore more ambiguous in the comparison between the EQ-5D-5L descriptive system score and the capabilities instruments than in the direct comparison of OxCAP-MH and ICECAP-A.ConclusionsAssessing outcomes in terms of capability for schizophrenic patients with depression provide more information than use of the NICE recommended QALY. OxCAP-MH and ICECAP-A show similar construct validity in severely ill mental health patients within the capability framework. Future research should extend the comparison of the properties of these instruments to other areas of mental health.

Quality of life instruments used in mental health research: Properties and utilization

2014 ◽  
Vol 215 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Amélie Prigent ◽  
Sandrine Simon ◽  
Isabelle Durand-Zaleski ◽  
Marion Leboyer ◽  
Karine Chevreul
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Health Research ◽  
Mental Health Research ◽  
Quality Of Life Instruments

Mental Health Status and Health-Related Quality of Life among Systemic Lupus Erythematosus (SLE) Patients in Thailand: A Multi-Site Study

2020 ◽  
Vol 103 (11) ◽  
pp. 1185-1193
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Health Status ◽  
Lupus Erythematosus ◽  
Self Esteem ◽  
Mental Health Status ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Background: The systemic lupus erythematosus (SLE) patients oftentimes suffer from both physical and psychosocial challenges that may lead to low health-related quality of life (HRQoL). However, limited research has been done in this area. Objective: To examined mental health status and HRQoL among SLE patients in Thailand. Materials and Methods: The present study was a cross-sectional study conducted at the rheumatology clinic of four major hospitals in Thailand. The paper-based questionnaire consisted of demographic, health history such as depression, anxiety, stress Scale (DASS-21), and the Rosenberg self-esteem scale (RSE), and the disease-specific Lupus Quality of Life scale (LupusQoL). Depending on the variable’s level of measurement such as categorical or continuous, Spearman’s Rho or Pearson’s product moment correlation coefficients were used to explore the relationships among the variables. Hierarchical multiple regression was used to identify the predictors of LupusQoL. Results: Among the 387 participants, many might have experienced depression, anxiety, and stress (30%, 51%, and 29%, respectively). Self-esteem among the participants was good (31.8 out of 40). All eight domains of LupusQoL were affected with intimate relationship domain being impacted the most. The overall LupusQoL was significantly associated with the number of prescribed medications (r=–0.23), depression (r=–0.70), anxiety (r=–0.58), stress (r=–0.67), and self-esteem (r=0.59), p<0.001. Significant predictors of the overall LupusQoL were mental health status (depression, anxiety, and stress) and self-esteem, F (3, 81)=43.10, p<0.001, adjusted R²=0.60. Conclusion: SLE patients should be holistically assessed in both physical and psychological aspects. In addition to proper medical treatments, healthcare providers should use a multidisciplinary team approach to resolve the patients’ psychosocial issues, which in turn, may increase the patients’ quality of life. Self-care education may be necessary to help the patients manage the condition and decrease the number of medications. Keywords: Mental health, Quality of life, SLE, Thailand

scholarly journals Is Helping Really Helping? Health-Related Quality of Life after TBI Predicting Caregiver Depression Symptom Trajectories in Latin America

2021 ◽  
Vol 18 (3) ◽  
pp. 1247
Author(s):  
Chimdindu Ohayagha ◽  
Paul B. Perrin ◽  
Annahir N. Cariello ◽  
Juan Carlos Arango-Lasprilla
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Latin America ◽  
Depression Symptom ◽  
Caregiver Depression ◽  
Symptom Trajectories ◽  
Related Quality ◽  
Health Related ◽  
Caregiver Mental Health

Previous research connecting health-related quality of life (HRQoL) in people with traumatic brain injury (TBI) and caregiver mental health has primarily been conducted cross-sectionally in the U.S. and Western Europe. This study, therefore, examined how HRQoL in individuals immediately after their TBI predicts longitudinal caregiver depression symptom trajectories in Latin America. A sample of 109 patients with an acute TBI and 109 caregivers (total n = 218) was recruited from three hospitals in Mexico City, Mexico, and in Cali and Neiva, Colombia. TBI patients reported their HRQoL while they were still in hospital, and caregivers reported their depression symptoms at the same time and at 2 and 4 months later. Hierarchal linear models (HLM) found that caregiver depression symptom scores decreased over time, and lower patient mental health and pain-related quality of life at baseline (higher pain) predicted higher overall caregiver depression symptom trajectories across the three time points. These findings suggest that in Latin America, there is an identifiable relationship between psychological and pain-related symptoms after TBI and caregiver depression symptom outcomes. The results highlight the importance of early detection of caregiver mental health needs based in part upon patient HRQoL and a culturally informed approach to rehabilitation services for Latin American TBI caregivers.

scholarly journals Psychosomatic interactions in kidney transplantation: role of personality dimensions in mental health-related quality of life

2021 ◽  
Vol 12 ◽  
pp. 204062232110243
Author(s):  
Federica Guerra ◽  
Jessica Ranieri ◽  
Domenico Passafiume ◽  
Diana Lupi ◽  
Daniela Maccarone ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Kidney Transplantation ◽  
Health Related Quality ◽  
Personality Dimensions ◽  
Related Quality ◽  
Health Related ◽  
Body Self ◽  
High Level

Background and aims: The increase in innovative and personalized medicine solutions in kidney surgery can improve patients’ chances of survival; however, during the transplantation process, patients are exposed to many psychological challenges. This study aimed to evaluate the role and impact of personality dimensions on the behaviour of waiting-list patients towards the post-surgery adaptation process. Method: The participants were 113 out-patients aged 18–70 years (mean age 54.7 years, SD ± 9.9) who had received a kidney transplant at least 3 years prior to the study. Results: The results of the study revealed that personality dimensions can predict mental health-related quality of life after kidney transplantation; in particular, the dimensions play an important role in patients’ behavioural ability to manage their quality of life both during end-stage renal disease and after kidney transplantation. Psychological distress and anxiety were associated with a low level of the conscientiousness dimension, while a high level of the openness dimension was associated with a high level of psychological distress and stress. In addition, body self-perception was associated with personality dimensions. Conclusion: Personality dimensions were found to predict behavioural reactions when emotional traits and body self-perception for each patient were combined; clinical psychologists could apply personalized intervention by modeling the treatments step by step and mitigating the negative effects of the whole kidney transplantation disease, thus helping the individual to adapt to a new life.

scholarly journals Prevalence and 11-year incidence of common eye diseases and their relation to health-related quality of life, mental health, and visual impairment

2021 ◽  
Author(s):  
Petri K. M. Purola ◽  
Janika E. Nättinen ◽  
Matti U. I. Ojamo ◽  
Seppo V. P. Koskinen ◽  
Harri A. Rissanen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Visual Impairment ◽  
Eye Diseases ◽  
Health Related Quality ◽  
Time Points ◽  
Related Quality ◽  
Health Related

Abstract Purpose To study the prevalence and incidence of the most common eye diseases and their relation to health-related quality of life (HRQoL), depression, psychological distress, and visual impairment in the aging population of Finland. Methods Our study was based on two nationwide health surveys conducted in 2000 and 2011. Eye disease status data were obtained from 7379 and 5710 individuals aged 30 + years, of whom 4620 partook in both time points. Both surveys included identical indicators of HRQoL (EuroQol-5 Dimension [EQ-5D], 15D), depression (Beck Depression Inventory [BDI]), psychological distress (General Health Questionnaire-12 [GHQ-12]), visual acuity, and self-reported eye diseases. We assessed the impact of known eye diseases on these factors, adjusted for age, gender, and co-morbidities. Results Prevalence of self-reported eye diseases was 3.1/2.7% for glaucoma, 8.1/11.4% for cataract, and 3.4/3.8% for retinal degeneration in 2000 and 2011, and the average incidence between 2000 and 2011 was 22, 109, and 35 /year/10,000 individuals, respectively. These eye diseases were associated with a significant decrease in EQ-5D and 15D index scores in both time points. BDI and GHQ-12 scores were also worsened, with some variation between different eye diseases. Impaired vision was, however, the strongest determinant of declined HRQoL. During the 11-year follow-up the effect of eye diseases on HRQoL and mental health diminished. Conclusion Declined HRQoL associated with eye diseases is more related to impaired vision than the awareness of the disease itself, and this declining effect diminished during the follow-up. Therefore, information directed to the public on the risks and prevention of blindness can and should be strengthened to prevent the deleterious effects of visual impairment.

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