scholarly journals Cerebral Venous Sinus Thrombosis (CVST): an emerging complication of SARS CoV-2 infection

2021 ◽  
Author(s):  
Nicola Maggialetti ◽  
GUALANO ALESSANDRA ◽  
Roberto Russo ◽  
Rocco Umberto Accogli ◽  
Amato Antonio Stabile Ianora
Keyword(s):  
Emergency Department ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Neurological Symptoms ◽  
Venous Sinus ◽  
Thrombotic Complication ◽  
Virus Binding ◽  
Case Presentation ◽  
Venous Sinus Thrombosis ◽  
Thrombotic Complications

Abstract Background: During Coronavirus (COVID-19) pandemic, SARS CoV-2 infection has been documented to be associated with thrombotic complications, especially pulmonary embolism, which are triggered by virus binding to ACE-2 receptors and consequent activation of a cascade leading to a hypercoagulable pathway, however Cerebral Venous Sinus Thrombosis (CVST) is emerging as a further thrombotic complication of COVID-19.Case presentation: We report our experience of a patient affected by SARS CoV-2 infection, who presented to our emergency department with neurological symptoms such as confusion and headache and was diagnosed with CVST at imaging exams.Conclusion: As neurological symptoms such as confusion and headache are aspecific and shared with patients affected by SARS CoV-2 infection in absence of CVST, clinicians should be aware of this emerging hematologic complication in order to recognize it as soon as possible and provide the best patient care.

scholarly journals Cerebral venous sinus thrombosis associated with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection

2021 ◽  
pp. 104-104
Author(s):  
Dragan Nikolic ◽  
Marijana Basta-Nikolic ◽  
Vladimir Manojlovic ◽  
Zeljko Zivanovic ◽  
Sanja Vickovic ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mortality Rate ◽  
Severe Acute Respiratory Syndrome ◽  
High Mortality ◽  
Clinical Presentation ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Neurological Symptoms ◽  
Venous Sinus ◽  
Venous Sinus Thrombosis

Introduction/Objective. Coagulopathy induced by severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2) can be an underlying cause of cerebral venous sinus thrombosis (CVST), a less common type of stroke with a variable clinical presentation and high mortality rate. Objective: to present a series of CVST cases associated with SARS-CoV-2 infection. Methods. This retrospective study evaluated clinical, laboratory and radiological presentation, risk factors, barriers to diagnosis, treatment and outcome of patients with SARS-CoV-2 infection induced CVST. Results. The study comprised 6 patients diagnosed with COVID-19 induced CVST during the 18 months period. Majority (66.7%) had no significant risk factors for developing CVST. Median time from initial COVID-19 diagnosis to onset of neurologic deficit was 7 days (interquartile range 0.5-7 days). Clinical presentation comprised non specific neurological symptoms: headache (83.3%) and decreased consciousness (33.3%), together with elevated levels of D-dimer and inflammatory biomarkers. The transverse (n = 4 or 66.7%), superior sagittal sinuses (n = 3 or 50%) and sigmoid sinus (n = 2 or 33.3%) were most commonly affected. Five patients (83.3%) had minimal to no symptoms at discharge (mRS ? 2). In-hospital mortality in our current series was relatively high (16.7%). Conclusion. The high mortality rate of SARS-CoV-2-associated CVST urges clinicians to suspect CVST in patients with a history of COVID-19 infection presenting with non-specific neurological symptoms in order to provide proper treatment and prevent complications.

A case report of extensive cerebral venous sinus thrombosis: a sequela of COVID-19?

2021 ◽  
Vol 20 (3) ◽  
pp. 219-222
Author(s):  
S Sivalokanathan ◽  
◽  
MO Syed ◽  
A Sharmila ◽  
◽  
...  
Keyword(s):  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Low Molecular Weight ◽  
Diagnostic Challenge ◽  
Venous Sinus Thrombosis ◽  
Refractory Headache ◽  
Thrombotic Complications ◽  
Medical Intensive Care ◽  
Persistent Headache

Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease that is often the trigger for thrombotic complications. Cerebral venous sinus thrombosis (CVST) represents a small percentage of strokes, frequently proving to be a diagnostic challenge. We report a 31-year-old lady presenting with a persistent headache, 18 weeks after a mild COVID-19 illness. On her second visit, CT venography revealed extensive CVST. She was commenced on low-molecular-weight heparin, and was monitored closely in the neuro-medical intensive care unit. She was discharged 2 weeks later, with no residual neurological deficit, and commenced on a direct oral anticoagulant in the community. CVST should be considered in patients presenting with a refractory headache, with greater suspicion if previously infected with SARS-CoV-2.

scholarly journals Extensive cerebral venous sinus thrombosis: a potential complication in a patient with COVID-19 disease

2020 ◽  
Vol 13 (8) ◽  
pp. e236820 ◽  
Author(s):  
Paul Bolaji ◽  
Babatunde Kukoyi ◽  
Nasar Ahmad ◽  
Chris Wharton
Keyword(s):  
Sinus Thrombosis ◽  
Inpatient Rehabilitation ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Pulmonary Vasculature ◽  
Venous Sinus Thrombosis ◽  
Ventilation Imaging ◽  
Potential Association ◽  
Thrombotic Complications ◽  
Recent Diagnosis

A 63-year-old man was admitted with left-sided weakness and subsequent focal seizures following a recent diagnosis of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia in a nearby hospital. He developed status epilepticus and became comatose, requiring intensive care unit admission for invasive ventilation. Imaging done at admission confirmed extensive cerebral venous sinus thrombosis (CVST) with bilateral venous cortical infarcts and acute cortical haemorrhage. No known risk factor for CVST could be identified. He improved with anticoagulation and antiepileptic therapy. He was subsequently transferred to an inpatient rehabilitation facility. Although Coronavirus disease 19 (COVID-19) infection has been previously associated with thrombotic complications, these mostly relate to the pulmonary vasculature. We present this case as a potential association between CVST and COVID-19 infection.

scholarly journals Case Report: Catheter-Directed Endovascular Thrombolysis for Refractory Cerebral Venous Sinus Thrombosis in a Patient With Behçet Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Yongfeng Xu ◽  
Minjian Qiu
Keyword(s):  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Behçet Disease ◽  
Behcet Disease ◽  
Case Presentation ◽  
Pulse Methylprednisolone ◽  
Venous Sinus Thrombosis ◽  
Catheter Directed Thrombolysis ◽  
Vasculitic Disorder

Background: Behçet disease (BD) is an autoimmune and vasculitic disorder. BD affects the veins more frequently than the arteries. The cerebral venous sinus thrombosis (CVST) was reported to occur in about 20% of neuro-BD. Huge dilemma exists in the treatment of CVST with BD, some of which were refractory to the standard therapy.Case Presentation: Here, we report a BD case with refractory intracranial hypertension caused by CVST which is successfully treated with catheter-directed endovascular thrombolysis. Before endovascular thrombolysis, intravenous pulse methylprednisolone combined with anticoagulant therapy was used, and resulted in limited effects.Conclusion: We conclude that catheter-directed thrombolysis may be considered for refractory CVST with BD, provided that coexistent pulmonary and cerebral artery aneurysms are ruled out.

scholarly journals Rare complication of COVID-19 presenting as isolated headache

2020 ◽  
Vol 13 (10) ◽  
pp. e239275
Author(s):  
Rehan Asif ◽  
Marcella Sinead O' Mahony
Keyword(s):  
Risk Factors ◽  
Sinus Thrombosis ◽  
Rare Complication ◽  
Cerebral Venous Sinus Thrombosis ◽  
Clinical Suspicion ◽  
Neurological Symptoms ◽  
High Index ◽  
Venous Sinus ◽  
Thrombotic Risk ◽  
Venous Sinus Thrombosis

An 18-year-old man presented with persistent isolated headache 2 weeks after recovering from acute COVID-19 illness. Extensive cerebral venous sinus thrombosis (CVST) was detected on CT venogram despite him having no other thrombotic risk factors. CVST can complicate COVID-19. A high index of clinical suspicion is warranted as it can often have a subtle presentation with paucity of neurological symptoms.

scholarly journals Presence of red flags in patients with cerebral venous sinus thrombosis admitted to the emergency department because of headache

Medicine ◽  
2020 ◽  
Vol 99 (29) ◽  
pp. e20900
Author(s):  
David García-Azorín ◽  
Mariana H.G. Monje ◽  
Nuria González-García ◽  
Ángel L. Guerrero ◽  
Jesús Porta-Etessam
Keyword(s):  
Emergency Department ◽  
Sinus Thrombosis ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Red Flags ◽  
Venous Sinus Thrombosis

Cases from the Cleveland Clinic: cerebral venous sinus thrombosis presenting to the emergency department with worst headache of life

2008 ◽  
Vol 16 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Orlando Cortez ◽  
Christopher J. Schaeffer ◽  
Stephen F. Hatem ◽  
Jonathan Glauser ◽  
Manzoor Ahmed
Keyword(s):  
Emergency Department ◽  
Sinus Thrombosis ◽  
Cleveland Clinic ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Venous Sinus Thrombosis
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