scholarly journals Retrospective Accuracy Analysis of MRI Based Lesion Size Measurement in Neuroblastic Tumors: Which Sequence Should We Choose?

2020 ◽  
Author(s):  
Sebastian Gassenmaier ◽  
Ilias Tsiflikas ◽  
Simon Maennlin ◽  
Cristian Urla ◽  
Steven W. Warmann ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tumor Size ◽  
Spin Echo ◽  
Three Dimensional ◽  
Lesion Size ◽  
Three Dimensions ◽  
Neuroblastic Tumor ◽  
Significant Difference ◽  
Dimensional Measurements ◽  
Neuroblastic Tumors

Abstract Background: MR imaging of neuroblastic tumors is widely used for assessing the effect of chemotherapy on tumor size. However, there are some concerns that MRI might falsely estimate lesion diameters due to calcification and fibrosis.Therefore, the aim of our study was to compare neuroblastic tumor size based on MRI measurements to histopathology as standard of reference.Methods: Inclusion criteria were diagnosis of a neuroblastic tumor, MR imaging within 100 days to surgery and gross total resection without fragmentation of the tumor between 2008-2019. Lesion diameters were measured by two radiologists according to RECIST 1.1 in axial plane in T2w turbo spin echo (TSE), diffusion-weighted imaging (DWI) and in T1w pre- and postcontrast sequences. Furthermore, the largest lesion size in three-dimensions was noted. The largest diameter of histopathology measurements was used for comparison with MRI.Results: Thirty-seven patients (mean age: 5±4 years) with 38 lesions (neuroblastoma: n=17; ganglioneuroblastoma: n=11; ganglioneuroma: n=10) were included in this retrospective study. There was excellent intra-class correlation coefficient between both readers for all sequences(>0.9)Tumor dimensions of reader 1 based on axial MRImeasurements were significantly smaller with the following median differences (cm): T1w precontrast-1.4 (interquartile range (IQR): 1.8 ), T1w postcontrast -1.0 (IQR: 1.9),T2w TSE:-1.0 (IQR: 1.6) and DWI -1.3 (IQR: 2.2) (p<0.001 for all sequences). However, the evaluation revealed no significant differences between the three-dimensional measurements and histopathology regardless of the applied MRI sequence.Conclusions: Axial MRI based lesion size measurementsare significantly smaller than histopathological measurements. However, there was no significant difference between three-dimensional measurements and histopathology. T2w TSE and T1w postcontrast images provided the lowest deviation and might consequently be preferred for measurements.

scholarly journals Retrospective accuracy analysis of MRI based lesion size measurement in neuroblastic tumors: which sequence should we choose?

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sebastian Gassenmaier ◽  
Ilias Tsiflikas ◽  
Simon Maennlin ◽  
Cristian Urla ◽  
Steven W. Warmann ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tumor Size ◽  
Three Dimensional ◽  
Lesion Size ◽  
Three Dimensions ◽  
Neuroblastic Tumor ◽  
Significant Difference ◽  
Dimensional Measurements ◽  
Neuroblastic Tumors ◽  
Mri Measurements

Abstract Background MR imaging of neuroblastic tumors is widely used for assessing the effect of chemotherapy on tumor size. However, there are some concerns that MRI might falsely estimate lesion diameters due to calcification and fibrosis. Therefore, the aim of our study was to compare neuroblastic tumor size based on MRI measurements to histopathology measurements of the resected specimens as standard of reference. Methods Inclusion criteria were diagnosis of a neuroblastic tumor, MR imaging within 100 days to surgery and gross total resection without fragmentation of the tumor between 2008 and 2019. Lesion diameters were measured by two radiologists according to RECIST 1.1 in axial plane in T2w turbo spin echo (TSE), diffusion-weighted imaging (DWI), and in T1w pre- and postcontrast sequences. Furthermore, the largest lesion size in three-dimensions was noted. The largest diameter of histopathology measurements of each specimen was used for comparison with MRI. Results Thirty-seven patients (mean age: 5 ± 4 years) with 38 lesions (neuroblastoma: n = 17; ganglioneuroblastoma: n = 11; ganglioneuroma: n = 10) were included in this retrospective study. There was excellent intra-class correlation coefficient between both readers for all sequences (> 0.9) Tumor dimensions of reader 1 based on axial MRI measurements were significantly smaller with the following median differences (cm): T1w precontrast − 1.4 (interquartile range (IQR): 1.8), T1w postcontrast − 1.0 (IQR: 1.9), T2w TSE: -1.0 (IQR: 1.6), and DWI -1.3 (IQR: 2.2) (p < 0.001 for all sequences). However, the evaluation revealed no significant differences between the three-dimensional measurements and histopathology measurements of the resected specimens regardless of the applied MRI sequence. Conclusions Axial MRI based lesion size measurements are significantly smaller than histopathological measurements. However, there was no significant difference between three-dimensional measurements and histopathology measurements of the resected specimens. T2w TSE and T1w postcontrast images provided the lowest deviation and might consequently be preferred for measurements.

scholarly journals Retrospective accuracy analysis of MRI based lesion size measurement in neuroblastic tumors: which sequence should we choose?

2020 ◽  
Author(s):  
Sebastian Gassenmaier ◽  
Ilias Tsiflikas ◽  
Simon Maennlin ◽  
Cristian Urla ◽  
Steven W. Warmann ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tumor Size ◽  
Three Dimensional ◽  
Lesion Size ◽  
Three Dimensions ◽  
Neuroblastic Tumor ◽  
Significant Difference ◽  
Dimensional Measurements ◽  
Neuroblastic Tumors ◽  
Mri Measurements

Abstract Background: MR imaging of neuroblastic tumors is widely used for assessing the effect of chemotherapy on tumor size. However, there are some concerns that MRI might falsely estimate lesion diameters due to calcification and fibrosis. Therefore, the aim of our study was to compare neuroblastic tumor size based on MRI measurements to histopathology measurements of the resected specimens as standard of reference.Methods: Inclusion criteria were diagnosis of a neuroblastic tumor, MR imaging within 100 days to surgery and gross total resection without fragmentation of the tumor between 2008-2019. Lesion diameters were measured by two radiologists according to RECIST 1.1 in axial plane in T2w turbo spin echo (TSE), diffusion-weighted imaging (DWI), and in T1w pre- and postcontrast sequences. Furthermore, the largest lesion size in three-dimensions was noted. The largest diameter of histopathology measurements of each specimen was used for comparison with MRI.Results: Thirty-seven patients (mean age: 5±4 years) with 38 lesions (neuroblastoma: n=17; ganglioneuroblastoma: n=11; ganglioneuroma: n=10) were included in this retrospective study. There was excellent intra-class correlation coefficient between both readers for all sequences (>0.9) Tumor dimensions of reader 1 based on axial MRI measurements were significantly smaller with the following median differences (cm): T1w precontrast -1.4 (interquartile range (IQR): 1.8 ), T1w postcontrast -1.0 (IQR: 1.9), T2w TSE: -1.0 (IQR: 1.6), and DWI -1.3 (IQR: 2.2) (p<0.001 for all sequences). However, the evaluation revealed no significant differences between the three-dimensional measurements and histopathology measurements of the resected specimens regardless of the applied MRI sequence.Conclusions: Axial MRI based lesion size measurements are significantly smaller than histopathological measurements. However, there was no significant difference between three-dimensional measurements and histopathology measurements of the resected specimens. T2w TSE and T1w postcontrast images provided the lowest deviation and might consequently be preferred for measurements.

scholarly journals Retrospective accuracy analysis of MRI based lesion size measurement in neuroblastic tumors: which sequence should we choose?

2020 ◽  
Author(s):  
Sebastian Gassenmaier ◽  
Ilias Tsiflikas ◽  
Simon Maennlin ◽  
Cristian Urla ◽  
Steven W. Warmann ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tumor Size ◽  
Three Dimensional ◽  
Lesion Size ◽  
Three Dimensions ◽  
Neuroblastic Tumor ◽  
Significant Difference ◽  
Dimensional Measurements ◽  
Neuroblastic Tumors ◽  
Mri Measurements

Abstract Background: MR imaging of neuroblastic tumors is widely used for assessing the effect of chemotherapy on tumor size. However, there are some concerns that MRI might falsely estimate lesion diameters due to calcification and fibrosis. Therefore, the aim of our study was to compare neuroblastic tumor size based on MRI measurements to histopathology measurements of the resected specimens as standard of reference.Methods: Inclusion criteria were diagnosis of a neuroblastic tumor, MR imaging within 100 days to surgery and gross total resection without fragmentation of the tumor between 2008-2019. Lesion diameters were measured by two radiologists according to RECIST 1.1 in axial plane in T2w turbo spin echo (TSE), diffusion-weighted imaging (DWI), and in T1w pre- and postcontrast sequences. Furthermore, the largest lesion size in three-dimensions was noted. The largest diameter of histopathology measurements of each specimen was used for comparison with MRI.Results: Thirty-seven patients (mean age: 5±4 years) with 38 lesions (neuroblastoma: n=17; ganglioneuroblastoma: n=11; ganglioneuroma: n=10) were included in this retrospective study. There was excellent intra-class correlation coefficient between both readers for all sequences (>0.9) Tumor dimensions of reader 1 based on axial MRI measurements were significantly smaller with the following median differences (cm): T1w precontrast -1.4 (interquartile range (IQR): 1.8 ), T1w postcontrast -1.0 (IQR: 1.9), T2w TSE: -1.0 (IQR: 1.6), and DWI -1.3 (IQR: 2.2) (p<0.001 for all sequences). However, the evaluation revealed no significant differences between the three-dimensional measurements and histopathology measurements of the resected specimens regardless of the applied MRI sequence.Conclusions: Axial MRI based lesion size measurements are significantly smaller than histopathological measurements. However, there was no significant difference between three-dimensional measurements and histopathology measurements of the resected specimens. T2w TSE and T1w postcontrast images provided the lowest deviation and might consequently be preferred for measurements.

Experimental hyaline cartilage lesions: Two-dimensional spin-echo versus three-dimensional gradient-echo MR imaging

1991 ◽  
Vol 1 (6) ◽  
pp. 665-672 ◽  
Author(s):  
Gerhard Adam ◽  
Claus Nolte-Ernsting ◽  
Andreas Prescher ◽  
Markus Bühne ◽  
Kira Bruchmüller ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Hyaline Cartilage ◽  
Spin Echo ◽  
Three Dimensional ◽  
Two Dimensional ◽  
Gradient Echo ◽  
Cartilage Lesions

Dynamic High-Field MR Imaging in Experimental Porcine Acute Pancreatitis

1995 ◽  
Vol 36 (2) ◽  
pp. 182-187 ◽  
Author(s):  
A. Piironen ◽  
R. Kivisaari ◽  
P. Pitkäranta ◽  
V.-P. Poutanen ◽  
P. Laippala ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Mr Imaging ◽  
High Field ◽  
Spin Echo ◽  
Flip Angle ◽  
Significant Difference ◽  
Before And After ◽  
The Difference ◽  
The Stability ◽  
Signal Intensities

The effects of acute pancreatitis on MR imaging signal intensities (SIs) were determined in an experimental study at 1.0 T. Oedematous pancreatitis was induced in 9 piglets and haemorrhagic pancreatitis in 11 piglets. Each animal served as its own control for MR imaging before and after induction of pancreatitis. T1-weighted spin echo (450/15 ms) and dynamic turbo FLASH (flip angle 8°) sequences were used without contrast medium in testing the stability of the SI measurements. There was no significant difference in the SI-versus-time curves of the pancreas in piglets with oedematous and haemorrhagic pancreatitis. However, the difference in mean SIs between healthy and diseased piglets was significant. Thus, although non-contrast MR may be useful in the diagnosis of acute pancreatitis, it does not distinguish between oedematous and haemorrhagic pancreatitis.

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