Bursty Topic Detection in Cancer Field Based on Multi-features of Burst Words

2020 ◽  
Author(s):  
xiaocui gong ◽  
xinying an ◽  
lianhui shan ◽  
yingxin hao ◽  
yifei li
Keyword(s):  
Breast Neoplasms ◽  
Medical Information ◽  
Triple Negative ◽  
Topic Detection ◽  
Molecular Pharmacology ◽  
Operating Process ◽  
Cancer Field ◽  
Treatment Research ◽  
Subject Areas ◽  
Triple Negative Breast Neoplasms

Abstract Background:With the increase in the amounts and types of medical information resources and the interdisciplinarity of the related works,it has become increasingly challenging for researchers and information personnel to grasp the theme development.Considering the prominent position of cancer field among all the subject areas in scientific research, and in order to carry out a new bursty topic detection method, the author proposes a method based on the multi-features of burst words and demonstrates its operating process. Methods:The main stages in the process include concept mapping,topic words extraction,burst words extraction,burst topics identification.This paper continues to take the study of breast neoplasms treatment research as a field to test the new method for identifying burst topics in medical research. Result:With this method,we identified four burst topics in breast neoplasms treatment research, including Molecular Targeted Therapy of Triple Negative Breast Neoplasms,molecular pharmacology of Triple Negative Breast Neoplasms,Immunological Antineoplastic Agents therapeutic use of Breast Neoplasms and Surgery therapy of Breast Neoplasms. Conclusion:The test results are highly concordant with authoritative literature reviews in the field and are further confirmed by interviews with the field’s leading experts,thus verifying the reliability of the techniques and approaches proposed by the study.

scholarly journals General rules for clinical and pathological studies on oral cancer (2nd edition): a synopsis

2021 ◽  
Vol 26 (4) ◽  
pp. 623-635
Author(s):  
Yoshihide Ota ◽  
◽  
Tadahide Noguchi ◽  
Eiichiro Ariji ◽  
Chihiro Fushimi ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Oral Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Medical Information ◽  
English Edition ◽  
General Rules ◽  
Treatment Research ◽  
Basic Concepts ◽  
8Th Edition

AbstractFor doctors and other medical staff treating oral cancer, it is necessary to standardize the basic concepts and rules for oral cancer to achieve progress in its treatment, research, and diagnosis. Oral cancer is an integral part of head and neck cancer and is treated in accordance with the general rules for head and neck cancer. However, detailed rules based on the specific characteristics of oral cancer are essential. The objective of this article was to contribute to the development of the diagnosis, treatment, and research of oral cancer, based on the correct and useful medical information of clinical, surgical, pathological, and imaging findings accumulated from individual patients at various institutions. Our general rules were revised as the UICC was revised for the 8th edition and were published as the Japanese second edition in 2019. In this paper, the English edition of the “Rules” section is primarily presented.

scholarly journals Teledermatology: From Prevention to Diagnosis of Nonmelanoma and Melanoma Skin Cancer

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
G. Fabbrocini ◽  
V. De Vita ◽  
F. Pastore ◽  
V. D'Arco ◽  
C. Mazzella ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Patient Outcomes ◽  
Medical Information ◽  
Clinical Medicine ◽  
Medical Procedures ◽  
Long Distance ◽  
Audiovisual Media ◽  
Cancer Field ◽  
Clinician Satisfaction ◽  
Melanoma Skin

Telemedicine is a rapidly developing application of clinical medicine where medical information is transferred through interactive audiovisual media for the purpose of consulting remote medical procedures or examinations, reducing the time of consultation for patients. Teledermatology as an application of telemedicine was developed in 1995: it turns out to be a gradually more ordinary mean of delivering dermatologic healthcare worldwide and will almost certainly have a greater medical function in the future. In particular, teledermatology can aid in the prevention and diagnosis of nonmelanoma and melanoma skin cancer; telemedicine and teledermatology offer the opportunity to make available consultations with experts also by long distance. Overall, patients seem to accept teledermatology, considering it as an excellent mean to obtain healthcare, particularly in those areas with no expert dermatologists available. Clinicians have also generally reported affirmative experiences with teledermatology in the skin cancer field. Further studies focusing on cost effectiveness, patient outcomes, and patient and clinician satisfaction will facilitate to delineate the potential of teledermatology as a mean of prevention and diagnosis of nonmelanoma and melanoma skin cancer.

scholarly journals Eribulin-based neoadjuvant chemotherapy for triple-negative breast cancer patients stratified by homologous recombination deficiency status: a multicenter randomized phase II clinical trial

2021 ◽  
Author(s):  
Norikazu Masuda ◽  
Hiroko Bando ◽  
Takashi Yamanaka ◽  
Takayuki Kadoya ◽  
Masato Takahashi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Homologous Recombination ◽  
Neoadjuvant Chemotherapy ◽  
Triple Negative Breast Cancer ◽  
Medical Information ◽  
Triple Negative ◽  
University Hospital ◽  
Breast Cancer Patients ◽  
Homologous Recombination Deficiency ◽  
Trial Number

Abstract Purpose To investigate clinical usefulness of eribulin-based neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) patients. Methods Patients in group A (aged < 65 years with homologous recombination deficiency, HRD, score ≥ 42, or those at any age with germline BRCA mutation, gBRCAm) were randomized to 4 cycles of paclitaxel plus carboplatin (group A1) or eribulin plus carboplatin (group A2), followed by 4 cycles of anthracycline. Patients in group B (aged < 65 years with HRD score < 42, or aged ≥ 65 years without gBRCAm) were randomized to 6 cycles of eribulin plus cyclophosphamide (group B1) or eribulin plus capecitabine (group B2); non-responders to the first 4 cycles of the eribulin-based therapy received anthracycline. Primary endpoint was pCR rate (ypT0-is, ypN0; centrally confirmed). Main secondary endpoint was safety. Results The full analysis set comprised 99 patients. The pCR rate was 65% (90% CI, 46%–81%) and 45% (27%–65%) in groups A1 and A2, respectively, and 19% (8%–35%) in both groups B1 and B2. No major difference was seen in secondary endpoints, but peripheral neuropathy incidence was 74% in group A1, whereas it was 32%, 22%, and 26% in groups A2, B1, and B2, respectively. Conclusions In patients aged < 65 years with high HRD score or gBRCAm, weekly paclitaxel plus carboplatin and eribulin plus carboplatin followed by anthracycline resulted in a pCR rate of > 60% and > 40%, respectively, suggesting potential usefulness of patient stratification using HRD; pCR tended to be low in patients with HRD-negative tumors. Neurotoxicity was less frequent with the eribulin-based regimen. Trial registration:The study has been registered with the University Hospital Medical Information Network Clinical Trials Registry (http://www.umin.ac.jp/ctr/index-j.htm) with unique trial number UMIN000023162. The Japan Breast Cancer Research Group trial number is JBCRG-22.

FEATURES OF PRELIMINARY PROCESSING OF SEMI-STRUCTURED MEDICAL DATA IN RUSSIAN FOR USE IN ENSEMBLES OF DATA MINING MODELS

2020 ◽  
pp. 44-54
Author(s):  
D. G. Lagerev ◽  
E. A. Makarova
Keyword(s):  
Medical Information ◽  
Hybrid Approach ◽  
Medical Data ◽  
Structured Data ◽  
Semantic Interpretation ◽  
Text Data ◽  
Medical Information Systems ◽  
Managerial Decisions ◽  
Automatic Methods ◽  
Subject Areas

The paper considers the problem of integration, processing and mining of poorly structured data of medical information systems in order to make managerial decisions in healthcare. The problems of medical data are described, such as the lack of a sufficient structure, a large number of abbreviations characteristic of specific nosologies, the complexity of the automatic semantic interpretation of some fields. The authors demonstrated an approach to the search and disclosure of abbreviation in texts, based on a combination of machine and human processing. The method proposed by the authors, based on a hybrid approach combining the strengths of machine and human processing, made it possible to increase the number of abbreviations found by automatic methods by 21 %, and also opened up to 55 % of cases in the automated mode (with a probability of correctness above 70 %) and significantly reduce the time spent by specialists in processing the remaining reductions. Further research will be aimed at solving the following problems associated with the processing and specificity of medical data, such as a large number of spelling errors, specific grammatical constructions. Using a hybrid approach to preprocessing poorly structured data will increase the efficiency of management decisions in the field of healthcare by reducing the time spent by experts on their creation and support. The hybrid approach to the preprocessing of text data in Russian can be applied in other subject areas. However, it may be necessary to adjust the technique to the specifics of the processed data.

Treatment for Progressive Impairments of Language

2010 ◽  
Vol 20 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Maya Henry
Keyword(s):  
Behavioral Treatment ◽  
Primary Progressive Aphasia ◽  
Sentence Production ◽  
Lexical Retrieval ◽  
Functional Communication ◽  
Language Performance ◽  
Communication Techniques ◽  
Primary Object ◽  
Behavioral Treatments ◽  
Treatment Research

Abstract Primary progressive aphasia (PPA) is a relatively new diagnostic entity, for which few behavioral treatments have been investigated. Recent work has helped to clarify the nature of distinct PPA variants, including a nonfluent variant (NFV-PPA), a logopenic variant (LV-PPA), and a semantic variant (SV-PPA). This paper reviews treatment research to date in each subtype of PPA, including restitutive, augmentative, and functional approaches. The evidence suggests that restitutive behavioral treatment can result in improved or stabilized language performance within treated domains. Specifically, sentence production and lexical retrieval have been addressed in NFV-PPA, whereas lexical retrieval has been the primary object of treatment in LV and SV-PPA. Use of augmentative communication techniques, as well as implementation of functional communication approaches, also may result in improved communication skills in individuals with PPA. The ideal treatment approach may be one that combines restitutive, augmentative, and functional approaches to treatment, in order to maximize residual cognitive-linguistic skills in patients. Additional research is warranted to determine which modes of treatment are most beneficial in each type of PPA at various stages of severity.

Fifth Edition: the New Standard

2000 ◽  
Vol 5 (6) ◽  
pp. 1-7
Author(s):  
Christopher R. Brigham ◽  
James B. Talmage ◽  
Leon H. Ensalada
Keyword(s):  
Musculoskeletal System ◽  
Medical Information ◽  
Objective Assessment ◽  
Scientific Data ◽  
Practical Application ◽  
Fourth Edition ◽  
Appropriate Use ◽  
Medical Evaluation ◽  
Single Set

Abstract The AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), Fifth Edition, is available and includes numerous changes that will affect both evaluators who and systems that use the AMA Guides. The Fifth Edition is nearly twice the size of its predecessor (613 pages vs 339 pages) and contains three additional chapters (the musculoskeletal system now is split into three chapters and the cardiovascular system into two). Table 1 shows how chapters in the Fifth Edition were reorganized from the Fourth Edition. In addition, each of the chapters is presented in a consistent format, as shown in Table 2. This article and subsequent issues of The Guides Newsletter will examine these changes, and the present discussion focuses on major revisions, particularly those in the first two chapters. (See Table 3 for a summary of the revisions to the musculoskeletal and pain chapters.) Chapter 1, Philosophy, Purpose, and Appropriate Use of the AMA Guides, emphasizes objective assessment necessitating a medical evaluation. Most impairment percentages in the Fifth Edition are unchanged from the Fourth because the majority of ratings currently are accepted, there is limited scientific data to support changes, and ratings should not be changed arbitrarily. Chapter 2, Practical Application of the AMA Guides, describes how to use the AMA Guides for consistent and reliable acquisition, analysis, communication, and utilization of medical information through a single set of standards.

Expanding the frontier of treatment research.

1999 ◽  
Vol 2 (1) ◽  
Author(s):  
Grayson Norquist ◽  
Barry Lebowitz ◽  
Steven Hyman
Keyword(s):  
Treatment Research
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