scholarly journals Catalytic Core-Shell Nanoparticles With Self-Supplied Calcium And H2O2 To Enable Combinational Tumor Inhibition

2021 ◽  
Author(s):  
Chao Fang ◽  
Hanjing Kong ◽  
Qiang Chu ◽  
Zefeng Hu ◽  
Yi Zhou ◽  
...  
Keyword(s):  
Calcium Ions ◽  
Ros Generation ◽  
Tumor Treatment ◽  
Shell Nanoparticles ◽  
Catalytic Core ◽  
Tumor Inhibition ◽  
Fenton Catalyst ◽  
Core Shell Nanoparticles

Abstract Nanoparticles, presenting catalytic activity to induce intracellular oxidative species, have been extensively explored for tumor treatment, but suffer daunting challenges in the limited intracellular H2O2 and thus suppressed therapeutic efficacy. Here in this study, a type of composite nanoparticles, consisting CaO2 core and Co-ferrocene shell, is designed and synthesized for combinational tumor treatment. The findings indicate that CaO2 core can be hydrolyzed to produce large amounts of H2O2 and calcium ions at the acidic tumor sites. Meanwhile, Co-ferrocene shell acts as an excellent Fenton catalyst, inducing considerable ROS generation following its reaction with H2O2. Excessive cellular oxidative stress triggers agitated calcium accumulation in addition to the calcium ions released from the particles. The combined effect of intracellular ROS and calcium overload causes significant tumor inhibition both in vitro and in vivo.

scholarly journals Catalytic core–shell nanoparticles with self-supplied calcium and H2O2 to enable combinational tumor inhibition

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hanjing Kong ◽  
Chao Fang ◽  
Qiang Chu ◽  
Zefeng Hu ◽  
Yike Fu ◽  
...  
Keyword(s):  
Calcium Ions ◽  
Ros Generation ◽  
Tumor Treatment ◽  
Shell Nanoparticles ◽  
Catalytic Core ◽  
Tumor Inhibition ◽  
Fenton Catalyst ◽  
Core Shell Nanoparticles

AbstractNanoparticles, presenting catalytic activity to induce intracellular oxidative species, have been extensively explored for tumor treatment, but suffer daunting challenges in the limited intracellular H2O2 and thus suppressed therapeutic efficacy. Here in this study, a type of composite nanoparticles, consisting CaO2 core and Co-ferrocene shell, is designed and synthesized for combinational tumor treatment. The findings indicate that CaO2 core can be hydrolyzed to produce large amounts of H2O2 and calcium ions at the acidic tumor sites. Meanwhile, Co-ferrocene shell acts as an excellent Fenton catalyst, inducing considerable ROS generation following its reaction with H2O2. Excessive cellular oxidative stress triggers agitated calcium accumulation in addition to the calcium ions released from the particles. The combined effect of intracellular ROS and calcium overload causes significant tumor inhibition both in vitro and in vivo.

scholarly journals Fe3O4@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Tong Chen ◽  
Qiang Chu ◽  
Mengyang Li ◽  
Gaorong Han ◽  
Xiang Li
Keyword(s):  
Fenton Reaction ◽  
Pt Nanoparticles ◽  
Therapeutic Modality ◽  
Ros Generation ◽  
Tumor Treatment ◽  
Superior Efficacy ◽  
Platinum Nanocrystals ◽  
First Time

AbstractElectrodynamic therapy (EDT) has recently emerged as a potential external field responsive approach for tumor treatment. While it presents a number of clear superiorities, EDT inherits the intrinsic challenges of current reactive oxygen species (ROS) based therapeutic treatments owing to the complex tumor microenvironment, including glutathione (GSH) overexpression, acidity and others. Herein for the first time, iron oxide nanoparticles are decorated using platinum nanocrystals (Fe3O4@Pt NPs) to integrate the current EDT with chemodynamic phenomenon and GSH depletion. Fe3O4@Pt NPs can effectively induce ROS generation based on the catalytic reaction on the surface of Pt nanoparticles triggered by electric field (E), and meanwhile it may catalyze intracellular H2O2 into ROS via Fenton reaction. In addition, Fe3+ ions released from Fe3O4@Pt NPs under the acidic condition in tumor cells consume GSH in a rapid fashion, inhibiting ROS clearance to enhance its antitumor efficacy. As a result, considerable in vitro and in vivo tumor inhibition phenomena are observed. This study has demonstrated an alternative concept of combinational therapeutic modality with superior efficacy.

scholarly journals An in vitro and in vivo bio-interaction responses and biosafety evaluation of novel Au–ZnTe core–shell nanoparticles

2016 ◽  
Vol 5 (4) ◽  
pp. 1078-1089 ◽  
Author(s):  
R. Dunpall ◽  
N. Revaprasadu
Keyword(s):  
Drug Delivery ◽  
Cancer Therapeutics ◽  
Surface Modifications ◽  
Core Shell ◽  
Support Surface ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Biosafety Evaluation

Novel gold–zinc telluride (Au–ZnTe) core–shell nanoparticles were synthesized to support surface modifications for enhanced drug delivery in cancer therapeutics.

ZnO@Gd2O3 core/shell nanoparticles for biomedical applications: Physicochemical, in vitro and in vivo characterization

2017 ◽  
Vol 80 ◽  
pp. 603-615 ◽  
Author(s):  
Anna Woźniak ◽  
Bartosz F. Grześkowiak ◽  
Nataliya Babayevska ◽  
Tomasz Zalewski ◽  
Monika Drobna ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
In Vivo Characterization

Isoniazid loaded core shell nanoparticles derived from PLGA–PEG–PLGA tri-block copolymers: In vitro and in vivo drug release

2013 ◽  
Vol 104 ◽  
pp. 107-115 ◽  
Author(s):  
Mani Gajendiran ◽  
Venkatachalam Gopi ◽  
Vellaichamy Elangovan ◽  
Rajagopalan Venkatakrishna Murali ◽  
Sengottuvelan Balasubramanian
Keyword(s):  
Block Copolymers ◽  
Drug Release ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

scholarly journals α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Tian Zhang ◽  
Qiang Zheng ◽  
Yike Fu ◽  
Congkun Xie ◽  
Gonglin Fan ◽  
...  
Keyword(s):  
Material Design ◽  
Hypoxic Condition ◽  
Ros Generation ◽  
Tumor Treatment ◽  
Sonodynamic Therapy ◽  
Imaging Guidance ◽  
Ultrasound Field ◽  
Content Of Oxygen

AbstractSonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered by the intrinsic hypoxia of solid tumor and the lack of smart design in material band structure. Here in study, fine α-Fe2O3 nanoparticles armored with Pt nanocrystals (α-Fe2O3@Pt) was investigated as an alternative SDT agent with ingenious bandgap and structural design. The Schottky barrier, due to its unique heterostructure, suppresses the recombination of sono-induced electrons and holes, enabling superior ROS generation. More importantly, the composite nanoparticles may effectively trigger a reoxygenation phenomenon to supply sufficient content of oxygen, favoring the ROS induction under the hypoxic condition and its extra role played for ultrasound imaging. In consequence, α-Fe2O3@Pt appears to enable effective tumor inhibition with imaging guidance, both in vitro and in vivo. This study has therefore demonstrated a highly potential platform for ultrasound-driven tumor theranostic, which may spark a series of further explorations in therapeutic systems with more rational material design. Graphical Abstract

Two-stage pH-sensitive doxorubicin hydrochloride loaded core–shell nanoparticles with dual drug-loading strategies for the potential anti-tumor treatment

RSC Advances ◽  
2016 ◽  
Vol 6 (106) ◽  
pp. 104049-104066 ◽  
Author(s):  
Xiaoyue Yu ◽  
Bo Zhang ◽  
Tianqi Wang ◽  
Jing Zhang ◽  
Shengjun Mu ◽  
...  
Keyword(s):  
Drug Loading ◽  
Ph Sensitive ◽  
Core Shell ◽  
Doxorubicin Hydrochloride ◽  
Tumor Treatment ◽  
Two Stage ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Dual Drug

Two-stage pH-sensitive DOX·HCl loaded core–shell nanoparticles (CPOD) with dual drug-loading strategies showed pretty in vivo anti-tumor efficacy.

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