scholarly journals Early colorectal cancer from “de novo” carcinogenesis with submucosal invasion: a case report and review of the literature

2021 ◽  
Author(s):  
hua jiang ◽  
chiyi he
Keyword(s):  
Colorectal Cancer ◽  
Case Report ◽  
De Novo ◽  
Normal Mucosa ◽  
Submucosal Invasion ◽  
Screening Colonoscopy ◽  
Early Colorectal Cancer ◽  
Lesion Type ◽  
De Novo Cancer ◽  
Low Incidence

Abstract Background: Colorectal cancer (CRC) mostly develops through the traditional “adenoma-carcinoma sequence”, however there is a rare “de novo” carcinogenic pathway in which cancer originates from normal mucosa. Here, we report a case of early CRC caused by “de novo” carcinogenesis with submucosal invasion and conduct a literature review of this special type of CRC.Case presentation: A 66-year-old man underwent a screening colonoscopy that revealed a polyp-like lesion (type 0-IIa+IIc in the Paris classification) approximately 0.5 cm in diameter in the descending colon. The patient underwent endoscopic submucosal dissection (ESD); postoperatively, he was pathologically diagnosed with moderately differentiated adenocarcinoma without an adenomatous component from the “de novo” carcinogenic pathway, accompanied by submucosal invasion to a depth of 600 μm. There was no venous or lymphatic permeation, and the margins were negative. A year later, follow-up examinations did not reveal tumour recurrence.Conclusions: Early “de novo” cancer has a low incidence and a low discovery rate through endoscopy. In this case report, we provide informative details about the presentation of such cancers under endoscopy and further support for the aggressive malignant potential of early “de novo” cancer. The development of advanced CRC can be effectively prevented, and the prognosis of these patients can be improved with active early treatment.

scholarly journals Depressed-Type Colonic Lesions and “De Novo” Cancer in Familial Adenomatous Polyposis: A Colonoscopist’s Viewpoint

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Shin-ei Kudo ◽  
Yuusaku Sugihara ◽  
Hiroyuki Kida ◽  
Fumio Ishida ◽  
Hideyuki Miyachi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Familial Adenomatous Polyposis ◽  
De Novo ◽  
Early Stage ◽  
Colorectal Cancers ◽  
Adenomatous Polyposis ◽  
Depressed Type ◽  
Polyposis Syndrome ◽  
De Novo Cancer ◽  
Almost All

Familial adenomatous polyposis (FAP) is the most common inherited polyposis syndrome. Almost all patients with FAP will develop colorectal cancer if their FAP is not identified and treated at an early stage. Although there are many reports about polypoid lesions and colorectal cancers in FAP patients, little information is available concerning depressed lesions in FAP patients. Several reports suggested that depressed-type lesions are characteristic of FAP and important in the light of their rapid growth and high malignancy. Here, we describe the occurrence of depressed-type lesions in FAP patients treated at our institution. Between April 2001 and March 2010, eight of 18 FAP patients had colorectal cancers. Depressed-type colorectal cancer was found in three patients. It should be kept in mind that depressed-type lesions occur even in FAP.

scholarly journals Downregulation of microRNA-100/microRNA-125b is associated with lymph node metastasis in early colorectal cancer with submucosal invasion

2017 ◽  
Vol 108 (3) ◽  
pp. 390-397 ◽  
Author(s):  
Yasuteru Fujino ◽  
Shunsaku Takeishi ◽  
Kensei Nishida ◽  
Koichi Okamoto ◽  
Naoki Muguruma ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Submucosal Invasion ◽  
Early Colorectal Cancer ◽  
Node Metastasis

scholarly journals Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247169
Author(s):  
Yusuke Kobayashi ◽  
Kensuke Kumamoto ◽  
Hirokazu Okayama ◽  
Takuro Matsumoto ◽  
Hiroshi Nakano ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Progression ◽  
De Novo ◽  
Prognostic Significance ◽  
Normal Mucosa ◽  
Stage Iii ◽  
Copy Number Loss ◽  
Prognostic Impact ◽  
Cancer Specific Survival ◽  
Adjacent Mucosa

Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) encodes an enzyme that catalyzes de novo purine biosynthesis. Although PAICS has been implicated as a potential therapeutic target in several cancers, its clinical and prognostic significance in colorectal cancer (CRC) is not fully understood. To elucidate the roles of PAICS in CRC, we investigated PAICS expression in four cohorts consisting of a total of 1659 samples based on quantitative RT-PCR, microarray and RNA-seq analysis. Despite upregulated PAICS levels in tumor compared to those of normal mucosa, we found a decreasing trend of PAICS expression during tumor progression and metastasis. We conducted immunohistochemistry on 252 specimens, showing that PAICS protein was strongly expressed in the majority of CRCs, but not in adjacent mucosa. Notably, 29.0% of tumors lacked PAICS staining, and PAICS-negative expression in tumor had significant prognostic impact on poor cancer-specific survival in stage III CRC. Correspondingly, decreased levels of PAICS transcript were also correlated with poor relapse-free survival particularly in stage III patients, and this finding was robustly confirmed in three microarray datasets of a total of 802 stage II-III patients. Bioinformatics analysis of CRC tissues and cell lines consistently indicated a correlation between decreased PAICS expression and copy number loss of chromosome arm 4q. In conclusion, our results suggest that PAICS expression is downregulated during tumor progression due to genetic deletion of chromosome 4q in microsatellite stable but chromosomally unstable tumors. Furthermore, decreased expression of PAICS transcript or loss of PAICS protein may provide prognostic stratification for postoperative patients with stage III CRC.

A Clinicopathological Study of IIa +IIc Type Early Colorectal Cancer with Massive Submucosal Invasion

1990 ◽  
Vol 2 (2) ◽  
pp. 148-155
Author(s):  
Shozo OKAMURA ◽  
Toshio ASAI ◽  
Hatsuhiro YAMAGUCHI ◽  
Eiji HAMAJIMA ◽  
Tadashi KATOH ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Submucosal Invasion ◽  
Early Colorectal Cancer ◽  
Clinicopathological Study

scholarly journals Ceramides Profile Identifies Patients with More Advanced Stages of Colorectal Cancer

Biomolecules ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 632
Author(s):  
Adam R. Markowski ◽  
Agnieszka U. Błachnio-Zabielska ◽  
Katarzyna Guzińska-Ustymowicz ◽  
Agnieszka Markowska ◽  
Karolina Pogodzińska ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Advanced Colorectal Cancer ◽  
De Novo ◽  
Early Stage ◽  
Early Colorectal Cancer ◽  
Cancer Tissue ◽  
Colorectal Cancer Tissue ◽  
Ceramide Synthesis ◽  
Advanced Stages ◽  
Colorectal Cancer Patients

Much attention is paid to different sphingolipid pathways because of their possible use in diagnostics and treatment. However, the activity status and significance of ceramide pathways in colorectal cancer are still unclear. We analyzed colorectal cancer patients to evaluate sphingolipid profiles in the blood, colorectal cancer (CRC) tissues, and healthy surrounding colorectal tissues of the same patient, simultaneously, using liquid chromatography coupled with triple quadrupole mass spectrometry. Furthermore, we measured protein expression of de novo ceramide synthesis enzymes and mitochondrial markers in tissues using western blot. We confirmed the different sphingolipid contents in colorectal cancer tissue compared to healthy surrounding tissues. Furthermore, we showed changed amounts of several ceramides in more advanced colorectal cancer tissue and found a prominently higher circulating level of several of them. Moreover, we observed a relationship between the amounts of some ceramide species in colorectal cancer tissue and plasma depending on the stage of colorectal cancer according to TNM (tumors, nodes, metastasis) classification. We think that the combined measurement of several ceramide concentrations in plasma can help distinguish early-stage lesions from advanced colorectal cancer and can help produce a screening test to detect early colorectal cancer.

scholarly journals A Comparison of Multiple Synchronous Colorectal Cancer in Ulcerative Colitis, Familial Polyposis Coli, and de Novo Cancer

1986 ◽  
Vol 203 (2) ◽  
pp. 123-128 ◽  
Author(s):  
ADRIAN J. GREENSTEIN ◽  
TOMAS M. HEIMANN ◽  
DAVID B. SACHAR ◽  
GARY SLATER ◽  
ARTHUR H. AUFSES
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Familial Polyposis ◽  
De Novo ◽  
Familial Polyposis Coli ◽  
Polyposis Coli ◽  
Synchronous Colorectal Cancer ◽  
De Novo Cancer

scholarly journals Clinicopathological analysis and management of early colorectal cancer with submucosal invasion.

1989 ◽  
Vol 22 (5) ◽  
pp. 1108-1115
Author(s):  
Satoshi SHIMODA ◽  
Terukazu MUTO ◽  
Katsuyoshi HATAKEYAMA ◽  
Yuichiro INOUE ◽  
Takeyasu SUDA
Keyword(s):  
Colorectal Cancer ◽  
Submucosal Invasion ◽  
Early Colorectal Cancer ◽  
Clinicopathological Analysis
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