scholarly journals Relationship between fibrinogen/albumin ratio and early renal damage markers in patients with hypertension

2021 ◽  
Author(s):  
jiankai jian dong ◽  
Yaping Zhang
Keyword(s):  
Renal Impairment ◽  
Cystatin C ◽  
Renal Damage ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Albumin Ratio ◽  
Hypertensive Patients ◽  
Factors Affecting ◽  
Β2 Microglobulin ◽  
Damage Indicators

Abstract Aim:To investigate the relationship between fibrinogen/albumin ratio (FAR) and early renal damage in hypertensive patients.Patients & methods:A retrospective study included 626 patients with hypertension, grouped according to the FAR tertiles and the presence or absence of early renal impairment. Early renal damage indicators[Serum cystatin c and β2 microglobulin] were detected in each group, and the differences between groups were compared, and the factors affecting early renal damage indicators were analyzed.Results:Serum cystatin c(CysC) and β2 microglobulin(β2-MG) levels in patients increased with FAR. In the renal impairment group, the fibrinogen and FAR were significantly increased, and serum albumin was decreased. FAR was positively correlated with β2-MG and CysC. Regression analysis showed that FAR level was a factor affecting blood β2-MG(β=6.632, p＜0.001)and CysC(β=1.991, p＜0.001).Conclusion:Elevated FAR is an independent risk factor for early renal damage in hypertensive patients

scholarly journals Serum Cystatin C and Tubular Urinary Enzymes as Biomarkers of Renal Dysfunction in Type 2 Diabetes Mellitus

2013 ◽  
Vol 6 ◽  
pp. CMED.S12633 ◽  
Author(s):  
Heba S. Assal ◽  
Salwa Tawfeek ◽  
Enas A. Rasheed ◽  
Dalia El-Lebedy ◽  
Eman H. Thabet
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Renal Dysfunction ◽  
Cystatin C ◽  
Renal Damage ◽  
Specific Marker ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Sensitive Marker

Renal tubulointerstitium plays an important role in the development and progression of diabetic nephropathy. The aim of this study was to assess serum cystatin C and 2 renal tubular enzymes, neutrophil gelatinase associated lipocalin (NGAL) and N-acetyl-beta-D-glucosaminidase (NAG), as screening markers for early renal dysfunction in patients with type 2 diabetes mellitus (T2DM). ROC curve analysis showed that urinary NAG is the most sensitive marker of microalbuminuria and early renal damage with sensitivity of 83.3%, while serum cystatin C was the most sensitive and specific marker of macroalbuminuria and damage progress with sensitivity of 70.8% and specificity of 83.3% versus 70.6% and 83.3% for uNGAL; and 64.7% and 66.7% for NAG, respectively. Our data indicate that urinary NAG is the most sensitive marker for early renal damage in diabetic patients. However, for damage progress, serum cystatin C is the most sensitive and specific marker for follow-up and monitoring renal dysfunction.

The effect of increased frequency of hemodialysis on serum cystatin C and β2-microglobulin concentrations: A secondary analysis of the frequent hemodialysis network (FHN) trial

2019 ◽  
Vol 23 (3) ◽  
pp. 297-305 ◽  
Author(s):  
Shih-Han S. Huang ◽  
George A. Kaysen ◽  
Nathan W. Levin ◽  
Alan S. Kliger ◽  
Gerald J. Beck ◽  
...  
Keyword(s):  
Cystatin C ◽  
Secondary Analysis ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Β2 Microglobulin ◽  
Frequent Hemodialysis
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