scholarly journals Antibody response of sheep to simultaneous vaccine administration of foot and mouth disease, blue tongue, peste des pestits ruminants , and sheep-goat pox antigens

2021 ◽  
Author(s):  
Beyhan Sareyyüpoğlu ◽  
Veli Gülyaz ◽  
Fahriye Saraç ◽  
Serdar Uzar ◽  
Özden Kabaklı ◽  
...  
Keyword(s):  
Immune Response ◽  
Antibody Response ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Live Virus ◽  
Vaccine Administration ◽  
Virus Challenge ◽  
Foot And Mouth ◽  
Antibody Titers ◽  
The Difference

Abstract There are many infectious animal diseases in Turkey and generally vaccination is the prime control strategy to combat them. However, it is difficult to apply all vaccines in a definite period in the field due to limitations of the labor and finance. The rapid vaccination and effective use of labor can be possible with the help of simultaneous vaccines administrations. The aim of the study is to show the effects of simultaneous foot-and-mouth disease (FMD), peste des pestits ruminants (PPR), sheep-goat pox (SGP) and bluetongue (BT) vaccine administration on the antibody response of sheep. For this aim, 30 sheep were divided in to the one experiment and 5 control groups. Blood samples collected in each group at 30 and 60 days post-vaccination (DPV). Immune response was measured with virus neutralization test (VNT), liquid phase blocking ELISA (LPBE) for FMDV, VNT for BTV and PPR. A live virus challenge study was performed to determine the immune response of SGP vaccine. As a result, antibody titers for each vaccine agent decreased on 60 DPV with the simultaneous vaccination. The difference between means of antibody titers with single and simultaneous vaccinations are significant especially for BTV and PPR vaccines at 60DPV (p < 0.05). It was concluded that four vaccines can not be used simultaneously in sheep.

scholarly journals Altered adjuvant of foot-and-mouth disease vaccine improves immune response and protection from virus challenge

2016 ◽  
Vol 5 ◽  
pp. 97-104 ◽  
Author(s):  
Min-Eun Park ◽  
Seo-Yong Lee ◽  
Rae-Hyung Kim ◽  
Mi-Kyeong Ko ◽  
Jeong-Nam Park ◽  
...  
Keyword(s):  
Immune Response ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Virus Challenge ◽  
Foot And Mouth

scholarly journals The B-cell response to foot-and-mouth-disease virus in cattle following vaccination and live-virus challenge

2016 ◽  
Vol 97 (9) ◽  
pp. 2201-2209 ◽  
Author(s):  
Clare F. J. Grant ◽  
B. Veronica Carr ◽  
Nagendrakumar B. Singanallur ◽  
Jacqueline Morris ◽  
Simon Gubbins ◽  
...  
Keyword(s):  
B Cell ◽  
Disease Virus ◽  
Cell Response ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Live Virus ◽  
Virus Challenge ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
B Cell Response

scholarly journals Immune response to virus-infection-associated (VIA) antigen in cattle repeatedly vaccinated with foot-and-mouth disease virus inactivated by formalin or acetylethyleneimine

1979 ◽  
Vol 82 (1) ◽  
pp. 41-50 ◽  
Author(s):  
A. A. Pinto ◽  
A. J. M. Garland
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
Antibody Response ◽  
Field Data ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Inactivated Vaccine ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Before And After

SUMMARYThe results of experiments to investigate antibody to ‘virus infection associated’ (VIA) antigen in cattle repeatedly vaccinated with formalin- or acetylethyleneimine- (AEI) inactivated foot-and-mouth disease (FMD) vaccines under laboratory conditions are reported. Results are also presented from some vaccinated animals subsequently exposed to FMD infection.Antibody against VIA was not detected before and after the first vaccination with formalin or AEI-inactivated vaccine but did develop in all animals after the second formalin vaccination and persisted throughout the experiment. After the second AEI vaccination, 4 of 12 animals developed antibody which persisted for at least 37 days. This transient response in some cattle was repeated after successive vaccinations but, in general, more animals responded as the number of vaccinations increased.After exposure to infection, a transient VIA antibody response was occasionally observed in immune AEI-vaccinated animals. Some immune repeatedly AEI-vaccinated cattle did not develop detectable VIA antibody after challenge despite the persistence of virus in oesophageal–pharyngeal (O/P) fluid.The presence of antibody to VIA antigen is not conclusive proof that vaccinated animals have been exposed to infection and field data must be interpreted with caution.

scholarly journals Advanced Foot-And-Mouth Disease Vaccine Platform for Stimulation of Simultaneous Cellular and Humoral Immune Responses

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 254
Author(s):  
Min Ja Lee ◽  
Hyundong Jo ◽  
So Hui Park ◽  
Mi-Kyeong Ko ◽  
Su-Mi Kim ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Clinical Symptoms ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vaccine Platform ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Foot And Mouth ◽  
Antibody Titers

Currently available commercial foot-and-mouth disease (FMD) vaccines have various limitations, such as the slow induction and short-term maintenance of antibody titers. Therefore, a novel FMD vaccine that can rapidly induce high neutralizing antibody titers to protect the host in early stages of an FMD virus infection, maintain high antibody titers for long periods after one vaccination dose, and confer full protection against clinical symptoms by simultaneously stimulating cellular and humoral immunity is needed. Here, we developed immunopotent FMD vaccine strains A-3A and A-HSP70, which elicit strong initial cellular immune response and induce humoral immune response, including long-lasting memory response. We purified the antigen (inactivated virus) derived from these immunopotent vaccine strains, and evaluated the immunogenicity and efficacy of the vaccines containing these antigens in mice and pigs. The immunopotent vaccine strains A-3A and A-HSP70 demonstrated superior immunogenicity compared with the A strain (backbone strain) in mice. The oil emulsion-free vaccine containing A-3A and A-HSP70 antigens effectively induced early, mid-term, and long-term immunity in mice and pigs by eliciting robust cellular and humoral immune responses through the activation of co-stimulatory molecules and the secretion of proinflammatory cytokines. We successfully derived an innovative FMD vaccine formulation to create more effective FMD vaccines.

scholarly journals Induction of a protective response in swine vaccinated with DNA encoding foot-and-mouth disease virus empty capsid proteins and the 3D RNA polymerase

2001 ◽  
Vol 82 (7) ◽  
pp. 1713-1724 ◽  
Author(s):  
Leticia Cedillo-Barrón ◽  
Mildred Foster-Cuevas ◽  
Graham J. Belsham ◽  
François Lefèvre ◽  
R. Michael E. Parkhouse
Keyword(s):  
Antibody Response ◽  
Disease Virus ◽  
Dna Vaccine ◽  
Virus Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Structural Protein ◽  
Live Virus ◽  
Mouth Disease Virus ◽  
Foot And Mouth

This work focuses on the development of a potential recombinant DNA vaccine against foot-and-mouth disease virus (FMDV). Such a vaccine would have significant advantages over the conventional inactivated virus vaccine, in particular having none of the risks associated with the high security requirements for working with live virus. The principal aim of this strategy was to stimulate an antibody response to native, neutralizing epitopes of empty FMDV capsids generated in vivo. Thus, a plasmid (pcDNA3.1/P1–2A3C3D) was constructed containing FMDV cDNA sequences encoding the viral structural protein precursor P1–2A and the non-structural proteins 3C and 3D. The 3C protein was included to ensure cleavage of the P1–2A precursor to VP0, VP1 and VP3, the components of self-assembling empty capsids. The non-structural protein 3D was also included in the construct in order to provide additional stimulation of CD4+ T cells. When swine were immunized with this plasmid, antibodies to FMDV and the 3D polymerase were synthesized. Furthermore, neutralizing antibodies were detected and, after three sequential vaccinations with DNA, some of the animals were protected against challenge with live virus. Additional experiments suggested that the antibody response to FMDV proteins was improved by the co-administration of a plasmid encoding porcine granulocyte–macrophage colony-stimulating factor. Although still not as effective as the conventional virus vaccine, the results encourage further work towards the development of a DNA vaccine against FMDV.

scholarly journals Effect of Foot-and-Mouth Disease Vaccination on Acute Phase Immune Response and Anovulation in Hanwoo (Bos taurus coreanae)

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 419
Author(s):  
Daehyun Kim ◽  
Joonho Moon ◽  
Jaejung Ha ◽  
Doyoon Kim ◽  
Junkoo Yi
Keyword(s):  
Immune Response ◽  
Artificial Insemination ◽  
Bos Taurus ◽  
Foot And Mouth Disease ◽  
Test Group ◽  
Mouth Disease ◽  
Control Group ◽  
Amyloid A ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Vaccination against foot-and-mouth disease is the most common method for preventing the spread of the disease; the negative effects include miscarriage, early embryo death, lower milk production, and decreased growth of fattening cattle. Therefore, in this study, we analyze the side effects of vaccination by determining the acute immune response and ovulation rate after vaccinating cows for foot-and-mouth disease. The test axis was synchronized with ovulation using 100 Hanwoo (Bos taurus coreanae) cows from the Gyeongsangbuk-do Livestock Research Institute; only individuals with estrus confirmed by ovarian ultrasound were used for the test. All test axes were artificially inseminated 21 days after the previous estrus date. The control group was administered 0.9% normal saline, the negative control was injected intramuscularly with lipopolysaccharide (LPS; 0.5 µg/kg), and the test group was administered a foot-and-mouth disease virus vaccine (FMDV vaccine; bioaftogen, O and A serotypes, inactivated vaccine) 2, 9, and 16 days before artificial insemination. White blood cells and neutrophils increased significantly 1 day after vaccination, and body temperature in the rumen increased for 16 h after vaccination. Ovulation was detected 1 day after artificial fertilization by ovarian ultrasound. The ovulation rates were as follows: control 89%, LPS 60%, FMDV vaccine (−2 d) 50%, FMDV vaccine (−9 d) 75%, and FMDV vaccine (−16 d) 75%. In particular, the FMDV vaccine (−2 d) test group confirmed that ovulation was delayed for 4 days after artificial insemination. In addition, it was confirmed that it took 9 days after inoculation for the plasma contents of haptoglobin and serum amyloid A to recover to the normal range as the main acute immune response factors. The conception rate of the FMDV vaccine (−2 d) group was 20%, which was significantly lower than that of the other test groups.

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