Surgery for Primary Giant Acinic Cell Carcinoma of Right Lung with Severe Mediastinal Deviation: A Case Report

Abstract Background: Primary lung acinic cell carcinoma is very rare.Here we report a young female patient who suffered the largest primary lung acinic cell carcinoma and severe mediastinal deviation at the same time which has never been reported before.Case presentation: A 27-years-old married female patient presented with recurrent coughing and hemoptysis for more than ten years came to our hospital.A chest computed tomography was performed in our hospital and showed a giant space-occupying lesion in the hilum of right lung.After a thorough and detailed preoperative examination,the patient then was performed a radical right pneumonectomy and mediastinal lymph node dissection.The specimens and pathology showed that the size of the tumor was about 8.6×4.5×4.4cm.The morphology of the tumor cell under microscope demonstrate a primary acinic cell carcinoma of right lung.The immunohistochemistry of the tumor showed AE1/AE3(+), Ki-67(2% +), CK7(+), Calponin(+/-), Vimentin(+), CK19(+), a-ACT(+), PAS(partial+). The patient was discharged two weeks after the operation.So far,the patient has been followed-up for one year, all the clinical test indexes are normal and no evidence of tumor recurrence or metastasis was observed. Conclusions: The primary acinic cell carcinoma of lung in this case is the biggest one ever been reported.The patient also had a very rare condition of severe mediastinal deviation.After surgical treatment, the patient recovered uneventfully and had stable disease without recurrence after one year of follow-up.This case indicates that acinic cell carcinoma of lung is of low malignancy, the prognosis and therapy effect of surgical treatment are satisfied.

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Right pneumonectomy for primary large acinic cell carcinoma (AciCC) with severe mediastinal deviation: a case report and literature review

BMC Surgery ◽

10.1186/s12893-021-01351-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xueyu Chen ◽

Yajie Zhang ◽

Fangxiu Luo ◽

Hecheng Li

Keyword(s):

Surgical Treatment ◽

Cell Carcinoma ◽

Female Patient ◽

Mediastinal Lymph Node ◽

Radical Right ◽

Acinic Cell Carcinoma ◽

Ki 67 ◽

Acinic Cell ◽

First Case ◽

Therapy Effect

Abstract Background Primary lung acinic cell carcinoma is very rare. Here we report a young female patient who suffered the largest primary lung acinic cell carcinoma with severe mediastinal deviation which has never been reported before. We also reviewed data and features of 20 previously reported cases of primary lung acinic cell carcinoma who underwent lobectomy. Case presentation A 27-year-old female patient presented with recurrent coughing and hemoptysis for more than 10 years came to our hospital. A chest computed tomography (CT) showed a giant space-occupying lesion in the hilum of right lung. After a thorough and detailed preoperative examination, the patient then was performed a radical right pneumonectomy with mediastinal lymph node dissection. The size of the tumor was about 8.6 × 4.5 × 4.4 cm. The pathological results demonstrated a primary acinic cell carcinoma of right lung. The immunohistochemistry of the tumor showed AE1/AE3 (+), Ki-67 (2% +), CK7 (+), Vimentin (+), CK19 (+), α1-ACT (+), AB-PAS (+), S-100 (−), TTF-1 (−). The patient was discharged less than 2 weeks after the operation. So far, the patient has been followed-up for 2 years, and no evidence of tumor recurrence or metastasis was observed. Conclusions The primary acinic cell carcinoma of lung in this case is the biggest one ever reported and also the first case treated with radical right pneumonectomy. In addition, the patient had a very rare condition of severe mediastinal deviation at the same time. After surgical treatment, the patient recovered uneventfully and had stable disease without recurrence and metastasis after 2 years of follow-up. This case together with the reported case indicate that primary acinic cell carcinoma of lung is of low malignancy, the prognosis and therapy effect of surgical treatment are relatively satisfactory.

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Laryngeal Acinic Cell Carcinoma Following Thyroid Irradiation

Otolaryngology ◽

10.1177/019459988108900308 ◽

1981 ◽

Vol 89 (3) ◽

pp. 398-401 ◽

Cited By ~ 2

Author(s):

James F. Reibel ◽

W. Copley McLean ◽

Robert W. Cantrell

Keyword(s):

Cell Carcinoma ◽

Medical Center ◽

Acinic Cell Carcinoma ◽

Prior History ◽

University Of Virginia ◽

Acinic Cell ◽

Thyroid Adenomas ◽

History Of ◽

One Year ◽

The University

Only three examples of acinic cell carcinoma of the larynx or trachea are found in the recent literature. A case of acinic cell carcinoma of the subglottic larynx and trachea was diagnosed and treated at the University of Virginia Medical Center. To our knowledge this is the first such case with a prior history of radiation to the neck. The patient is a 56-year-old woman who was irradiated for hyperthyroidism 46 years ago. When seen she also had parathyroid hyperplasia and multiple thyroid adenomas, conditions that frequently follow irradiation of the thyroid in children. These findings in this case support the concept that radiation may be responsible for inducing this tumor, which otherwise rarely occurs in this location. The use of electron microscopy was extremely useful in the diagnosis of this tumor. She was treated with total laryngectomy and right neck dissection and is now free of disease one year after surgery.

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PRIMARY ACINIC CELL CARCINOMA IN A YOUNG FEMALE PATIENT: A CASE REPORT

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2021.03.175 ◽

2021 ◽

Vol 132 (1) ◽

pp. e49

Author(s):

M Venkatasami ◽

K Harrison

Keyword(s):

Case Report ◽

Cell Carcinoma ◽

Female Patient ◽

Young Female ◽

Acinic Cell Carcinoma ◽

Acinic Cell

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Stromal reaction and prognosis in acinic cell carcinoma of the salivary gland

Vojnosanitetski pregled ◽

10.2298/vsp1312155j ◽

2013 ◽

Vol 70 (12) ◽

pp. 1155-1158

Author(s):

Ljubinka Jankovic-Velickovic ◽

Irena Dimov ◽

Dragan Petrovic ◽

Slavica Stojnev ◽

Stefan Dacic ◽

...

Keyword(s):

Salivary Gland ◽

Cell Carcinoma ◽

Malignant Neoplasm ◽

Tumor Stroma ◽

Acinic Cell Carcinoma ◽

Molecular Profile ◽

High Grade ◽

Ki 67 ◽

Stromal Reaction ◽

Acinic Cell

Introduction. Primary acinic cell carcinoma (ACC) is an uncommon malignant neoplasm of the salivary gland (SG), which usually presents as slow growing tumor. Case report. We reported a 69-year-old woman with tumor in the right parotid gland with a 5-year progress. Biopsy sections revealed a hybrid form of ACC with a low- and high-grade component and prominent lymphoid tissue in tumor stroma. Immunohistochemistry was performed to define the molecular profile of this unusual ACC, with special interest for stromal influence on to the proliferative activity of ACC with dedifferentiation. We detected that the level and the type of stromal lymphoid reaction (particularly CD8+/CD4+ ratio) had a significant influence on to Ki-67 index in the high-grade component of ACC, as well as the involvement of the CXCR4 signaling axis in the stromal reaction influence. Conclusion. We suggest that tumor stroma may be a source of potential new tumor biomarkers which can determine the aggressivity of this tumor.

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Acinic Cell Carcinoma of the Breast: Report of a Case With Immunohistochemical and Next-Generation Sequencing Studies

International Journal of Surgical Pathology ◽

10.1177/10668969211008508 ◽

2021 ◽

pp. 106689692110085

Author(s):

Kaitlin D. Weaver ◽

James Isom ◽

Ashwini Esnakula ◽

Karen Daily ◽

Jaya R. Asirvatham

Keyword(s):

Next Generation Sequencing ◽

Cell Carcinoma ◽

Triple Negative ◽

Ductal Carcinoma ◽

Left Breast ◽

Acinic Cell Carcinoma ◽

Next Generation ◽

Carcinoma Of The Breast ◽

Acinic Cell ◽

Generation Sequencing

Acinic cell carcinoma of the breast is a rare subtype of triple-negative breast cancer that recapitulates the appearance of tumors seen in salivary glands. We present the case of a 42-year-old woman with an irregular, nontender mass above the left nipple during routine obstetric appointment at 24 weeks gestation. She was subsequently diagnosed with triple-negative invasive ductal carcinoma of the left breast, Nottingham grade 3, via core needle biopsy. She was treated with neoadjuvant therapy (doxorubucin and cyclophosphamide) antenatally and paclitaxel in the postpartum period followed by left mastectomy with sentinel node biopsy. The carcinoma in the mastectomy specimen showed a spectrum of morphologic patterns with immunohistochemistry revealing strong positivity for alpha-1-antichymotrypsin, epithelial membrane antigen (EMA), lysozyme, and S100. The histomorphology paired with the immunoprofile led us to the diagnosis of acinic cell carcinoma. We retrospectively performed immunostains in the core biopsy specimen, which demonstrated GATA-3 and DOG-1 positivity. Next-generation sequencing of the postneoadjuvant specimen using a 70-gene panel revealed 2 single-nucleotide variant (SNV) mutations: tumor protein 53 (TP53) (c.747G>T) SNV mutation and rearranged during transfection (RET) (c.2899G>A) SNV mutation.

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