Laryngeal Acinic Cell Carcinoma Following Thyroid Irradiation

Only three examples of acinic cell carcinoma of the larynx or trachea are found in the recent literature. A case of acinic cell carcinoma of the subglottic larynx and trachea was diagnosed and treated at the University of Virginia Medical Center. To our knowledge this is the first such case with a prior history of radiation to the neck. The patient is a 56-year-old woman who was irradiated for hyperthyroidism 46 years ago. When seen she also had parathyroid hyperplasia and multiple thyroid adenomas, conditions that frequently follow irradiation of the thyroid in children. These findings in this case support the concept that radiation may be responsible for inducing this tumor, which otherwise rarely occurs in this location. The use of electron microscopy was extremely useful in the diagnosis of this tumor. She was treated with total laryngectomy and right neck dissection and is now free of disease one year after surgery.

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Surgery for Primary Giant Acinic Cell Carcinoma of Right Lung with Severe Mediastinal Deviation: A Case Report

10.21203/rs.3.rs-92128/v1 ◽

2020 ◽

Author(s):

Xueyu Chen ◽

Nengchong Zhang ◽

Fangxiu Luo ◽

Lianggang Zhu

Keyword(s):

Surgical Treatment ◽

Cell Carcinoma ◽

Female Patient ◽

Mediastinal Lymph Node ◽

Acinic Cell Carcinoma ◽

Clinical Test ◽

Ki 67 ◽

Acinic Cell ◽

Therapy Effect ◽

One Year

Abstract Background: Primary lung acinic cell carcinoma is very rare.Here we report a young female patient who suffered the largest primary lung acinic cell carcinoma and severe mediastinal deviation at the same time which has never been reported before.Case presentation: A 27-years-old married female patient presented with recurrent coughing and hemoptysis for more than ten years came to our hospital.A chest computed tomography was performed in our hospital and showed a giant space-occupying lesion in the hilum of right lung.After a thorough and detailed preoperative examination,the patient then was performed a radical right pneumonectomy and mediastinal lymph node dissection.The specimens and pathology showed that the size of the tumor was about 8.6×4.5×4.4cm.The morphology of the tumor cell under microscope demonstrate a primary acinic cell carcinoma of right lung.The immunohistochemistry of the tumor showed AE1/AE3(+), Ki-67(2% +), CK7(+), Calponin(+/-), Vimentin(+), CK19(+), a-ACT(+), PAS(partial+). The patient was discharged two weeks after the operation.So far,the patient has been followed-up for one year, all the clinical test indexes are normal and no evidence of tumor recurrence or metastasis was observed. Conclusions: The primary acinic cell carcinoma of lung in this case is the biggest one ever been reported.The patient also had a very rare condition of severe mediastinal deviation.After surgical treatment, the patient recovered uneventfully and had stable disease without recurrence after one year of follow-up.This case indicates that acinic cell carcinoma of lung is of low malignancy, the prognosis and therapy effect of surgical treatment are satisfied.

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High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant

Case Reports in Otolaryngology ◽

10.1155/2017/7296467 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 4

Author(s):

Sarah S. Al-Otaibi ◽

Faiza Alotaibi ◽

Yaseer Al Zaher ◽

Nabil Al Zaher ◽

M. A. Dababo

Keyword(s):

Cell Carcinoma ◽

Acinic Cell Carcinoma ◽

Low Grade ◽

High Grade ◽

Acinic Cell ◽

Facial Swelling ◽

Unusual Variant ◽

History Of ◽

High Grade Transformation ◽

Aggressive Clinical Course

Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology.

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High Risk of One-year Stroke Recurrence in Patients with Younger Age and Prior History of Ischemic Stroke

Current Neurovascular Research ◽

10.2174/1567202616666190618164528 ◽

2019 ◽

Vol 16 (3) ◽

pp. 250-257 ◽

Cited By ~ 1

Author(s):

Jiann-Der Lee ◽

Ya-Han Hu ◽

Meng Lee ◽

Yen-Chu Huang ◽

Ya-Wen Kuo ◽

...

Keyword(s):

Logistic Regression ◽

Ischemic Stroke ◽

Multivariate Logistic Regression Analysis ◽

Stroke Recurrence ◽

Prior History ◽

Multivariate Logistic Regression ◽

Cart Analysis ◽

Younger Age ◽

History Of ◽

One Year

Background and Purpose: Recurrent ischemic strokes increase the risk of disability and mortality. The role of conventional risk factors in recurrent strokes may change due to increased awareness of prevention strategies. The aim of this study was to explore the potential risk factors besides conventional ones which may help to affect the advances in future preventive concepts associated with one-year stroke recurrence (OSR). Methods: We analyzed 6,632 adult patients with ischemic stroke. Differences in clinical characteristics between patients with and without OSR were analyzed using multivariate logistic regression and classification and regression tree (CART) analyses. Results: Among the study population, 525 patients (7.9%) had OSR. Multivariate logistic regression analysis revealed that male sex (OR 1.243, 95% CI 1.025 – 1.506), age (OR 1.015, 95% CI 1.007 - 1.023), and a prior history of ischemic stroke (OR 1.331, 95% CI 1.096 – 1.615) were major factors associated with OSR. CART analysis further identified age and a prior history of ischemic stroke were important factors for OSR when classified the patients into three subgroups (with risks of OSR of 8.8%, 3.8%, and 12.5% for patients aged > 57.5 years, ≤ 57.5 years/with no prior history of ischemic stroke, and ≤ 57.5 years/with a prior history of ischemic stroke, respectively). Conclusions: Male sex, age, and a prior history of ischemic stroke could increase the risk of OSR by multivariate logistic regression analysis, and CART analysis further demonstrated that patients with a younger age (≤ 57.5 years) and a prior history of ischemic stroke had the highest risk of OSR.

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Acinic Cell Carcinoma of the Breast: Report of a Case With Immunohistochemical and Next-Generation Sequencing Studies

International Journal of Surgical Pathology ◽

10.1177/10668969211008508 ◽

2021 ◽

pp. 106689692110085

Author(s):

Kaitlin D. Weaver ◽

James Isom ◽

Ashwini Esnakula ◽

Karen Daily ◽

Jaya R. Asirvatham

Keyword(s):

Next Generation Sequencing ◽

Cell Carcinoma ◽

Triple Negative ◽

Ductal Carcinoma ◽

Left Breast ◽

Acinic Cell Carcinoma ◽

Next Generation ◽

Carcinoma Of The Breast ◽

Acinic Cell ◽

Generation Sequencing

Acinic cell carcinoma of the breast is a rare subtype of triple-negative breast cancer that recapitulates the appearance of tumors seen in salivary glands. We present the case of a 42-year-old woman with an irregular, nontender mass above the left nipple during routine obstetric appointment at 24 weeks gestation. She was subsequently diagnosed with triple-negative invasive ductal carcinoma of the left breast, Nottingham grade 3, via core needle biopsy. She was treated with neoadjuvant therapy (doxorubucin and cyclophosphamide) antenatally and paclitaxel in the postpartum period followed by left mastectomy with sentinel node biopsy. The carcinoma in the mastectomy specimen showed a spectrum of morphologic patterns with immunohistochemistry revealing strong positivity for alpha-1-antichymotrypsin, epithelial membrane antigen (EMA), lysozyme, and S100. The histomorphology paired with the immunoprofile led us to the diagnosis of acinic cell carcinoma. We retrospectively performed immunostains in the core biopsy specimen, which demonstrated GATA-3 and DOG-1 positivity. Next-generation sequencing of the postneoadjuvant specimen using a 70-gene panel revealed 2 single-nucleotide variant (SNV) mutations: tumor protein 53 (TP53) (c.747G>T) SNV mutation and rearranged during transfection (RET) (c.2899G>A) SNV mutation.

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