Characteristics of Intestinal Microbiota and Mother's Reproductive Tract Flora in Children With Down Syndrome

Abstract Background: Patients with Down’s syndrome (DS) often have an increased rate of infections, hypertension, objectivity and gastrointestinal disorders, which are the most common abnormalities and have a significant impact on their daily life. The gut microbiota plays an important role in maintaining gut homeostasis and improving immunity and has been linked to the development of obesity, hypertension, and colon cancer. However, there are few studies on the intestinal flora and the mother's reproductive tract flora of children with DS in childhood. Therefore, 16S sequencing technology was used to analyze and explore the intestinal flora of children with DS and CHD patients in DS and the microbial abundance and diversity composition in the mother's reproductive tract. Results: We found that the gut microbiota in children with DS was mainly composed of Escherichia, Bifidobacterium, Clostridium and Bacteroides, which have significant differences in the abundance and diversity of intestinal flora compared with healthy children, and the abundance of Enterococcus and Erysipelatoclostridium in the intestine of children with CHD was significantly higher than that of children without CHD, and the relative abundance of Lactobacillus in the reproductive tract of mothers with DS was significantly higher than that of mothers with healthy children, which may suggest potential ways of using microbiome composition for prognosis and diagnosis. Through functional analysis, it was found that Down’s syndrome patients significantly downregulated immune system and their cell growth and nucleotide metabolism were lower than those of healthy children.Conclusion: We performed 16S rRNA gene sequencing on fecal samples from 60 children and vaginal swab samples from 63 mothers to identify a number of potentially important taxonomic, functional and microbiomes associated with congenital heart disease and Down’s syndrome. Structural changes and its correlation with the mother’s vaginal flora. Our analysis shows that the ecosystem associated with childhood congenital heart disease affects the selection of bacterial communities in the native microbiota, and we focus on specific bacteria and their relevance to disease.

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The association of congenital heart disease with down's syndrome (mongolism)

The American Journal of Cardiology ◽

10.1016/0002-9149(69)90428-7 ◽

1969 ◽

Vol 24 (3) ◽

pp. 354-357 ◽

Cited By ~ 37

Author(s):

Lawrence Cullum ◽

Jerome Liebman

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Heart ◽

Down's Syndrome ◽

Down’S Syndrome

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Down's Syndrome with Congenital Heart Disease: Analysis of Cases Over Two Years in a Non-Invasive Laboratory of a Tertiary Hospital

Cardiovascular Journal ◽

10.3329/cardio.v2i2.6637 ◽

1970 ◽

Vol 2 (2) ◽

pp. 184-187

Author(s):

NN Fatema

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Doppler Echocardiography ◽

Congenital Heart ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Tertiary Hospital ◽

Study Group ◽

Non Invasive ◽

Study Results

Background: Trisomy 21 or Down's Syndrome is the most frequent chromosomal aberration affecting live birth infants with an incidence of 1 in 660 live births. This syndrome is often associated with congenital cardiac lesions, Incidence of which is 40-60 percent. This study was conducted to see the frequency of Down’s syndrome cases and pattern of heart diseases they have in one of the busy non-invasive pediatric cardiac laboratory of the country. Methods: It was a retrospective study conducted in the non-invasive pediatric cardiac laboratory and pediatric cardiac outpatient clinic of a tertiary hospital over a period of two years (November 2007 to October 2009). The entire patients who had Down's Syndrome and had Doppler echocardiography were included in the study. Results: Out of total six thousand and fifty echocardiography, Down's Syndrome case was 205 (3.38%). Out of 205 cases, 185 cases were followed up in pediatric cardiac out patient clinic. Twenty cases had not reported in the out patient clinic. Seventeen of those patients had normal cardiac anatomy in Doppler echocardiography. Male were 43.90% and female were 56.09% amongst study group. Most of the patients are young infant (47.32%). Only 2.44% are in more than 10 years age group. Murmur was audible in 86.49% cases in study group and developmental delay was present in 100% of the cases. Doppler Echocardiography was found as most sensitive and specific investigation for detecting congenital heart disease. A-V canal defect was the commonest association (15.60%). Congenital heart disease was not detected in 8.29% cases. Surgical treatment was advised in 52.19% cases, Device closure was advised in 16.59% cases, medical management was advised in 21.46% cases. Conclusion: Down's syndrome is a very common chromosomal anomaly in our country. Incidence of this syndrome is increasing as number of working women, late marriage and elderly mother increasing. So, multidisciplinary approach for managing this disease should be adopted immediately. Keywords: Down's syndrome; Congenital heart disease. DOI: 10.3329/cardio.v2i2.6637Cardiovasc. j. 2010; 2(2) : 184-187

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