Combined release of antiseptic and antibiotic drugs from visible light polymerized biodegradable nanocomposite hydrogels for periodontitis treatment
Abstract The in-situ used combination of different types of drugs revolutionized the area of periodontal therapy. The purpose of this study was to develop biodegradable nanocomposite hydrogel (NCHG) as a pH-sensitive drug delivery system. To reach the local applicability of the NCHG in dental practice routinely used blue-light photopolymerization was chosen for the preparation. The reaction time was 60 seconds, which resulted in stable hydrogel structures. Universal Britton-Robinson buffer solutions were used to investigate only the effect of pH for the release of the periodontal pocket useable drugs in the 4-12 range. The release of metronidazole was faster, it came out from the NCHGs within 12 hours, but the chlorhexidine had shown a longer elution time, which was more than 7 days as far as the antiseptic effect was maintained. The release of chlorhexidine showed strong pH depending. The biocompatibility of the NCHGs was proved by Alamar-blue test, and the effectiveness of drug release in the acidic medium was demonstrated. This fast photopolymerizable NCHG can help to approach an ideal locally useable combined drug delivery system which can be used in the amount required of the medicines and can reduce the side effects with the increased effectiveness by following pH changes.
