Injectable Drug Delivery System Based on In Situ Self‐Assembly of Liquid Star Polyethylene Glycol–Poly(lactic‐
            co
            ‐glycolic acid)

Flaky graphene oxide (GO) nanoparticles (NPs) were synthesized using Hummer’s method and then capped with polyethylene glycol (PEG) by an esterification reaction, then loaded with Nigella sativa (N. sativa) seed extract. Aiming to investigate their potential use as a smart drug delivery system against Staphylococcus aureus and Escherichia coli, the spectral and structural characteristics of GO-PEG NPs were comprehensively analyzed by XRD, AFM, TEM, FTIR, and UV- Vis. XRD patterns revealed that GO-PEG had different crystalline structures and defects, as well as a higher interlayer spacing. AFM results showed GONPs with the main grain size of 24.41 nm, while GONPs–PEG revealed graphene oxide aggregation with the main grain size of 287.04 nm after loading N. sativa seed extract, which was verified by TEM examination. A strong OH bond appeared in FTIR spectra. Furthermore, UV- Vis absorbance peaks at (275, 284, 324, and 327) nm seemed to be correlated with GONPs, GO–PEG, N. sativa seed extract, and GO –PEG- N. sativa extract. The drug delivery system was observed to destroy the bacteria by permeating the bacterial nucleic acid and cytoplasmic membrane, resulting in the loss of cell wall integrity, nucleic acid damage, and increased cell-wall permeability.

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In Vitro and In Vivo Drug Release from a Novel In Situ Forming Drug Delivery System

Pharmaceutical Research ◽

10.1007/s11095-007-9478-y ◽

2007 ◽

Vol 25 (6) ◽

pp. 1347-1354 ◽

Cited By ~ 38

Author(s):

Heiko Kranz ◽

Erol Yilmaz ◽

Gayle A. Brazeau ◽

Roland Bodmeier

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

In Situ Forming

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New in-situ synthetized hydrogel composite based on alginate and brushite as a potential pH sensitive drug delivery system

Carbohydrate Polymers ◽

10.1016/j.carbpol.2017.08.046 ◽

2017 ◽

Vol 177 ◽

pp. 324-333 ◽

Cited By ~ 22

Author(s):

Seyed Mohammad Hossein Dabiri ◽

Alberto Lagazzo ◽

Fabrizio Barberis ◽

Amirreza Shayganpour ◽

Elisabetta Finocchio ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Ph Sensitive ◽

Hydrogel Composite

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Nanoparticulate targeted drug delivery systems - A Review

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i2.2246 ◽

2020 ◽

Vol 11 (2) ◽

pp. 2505-2518

Author(s):

Sindhuja Devaraj ◽

Ganesh GNK

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Self Assembly ◽

Drug Targeting ◽

Drug Delivery Systems ◽

Therapeutic Index ◽

Delivery Systems ◽

Developing System ◽

General Method

Nanoparticulate drug delivery system are the rapidly developing system, and nanoparticles are present in the size range of 1-100nm. Nanoparticles composed of various thermal, electrical, and optical property. Nanoparticles offers the potential advantages over the traditional dosage forms it is ascribable to the properties of nanoparticles. Nanoparticulate drug delivery system ensures the site-specific delivery of a drug(Targeting drug delivery) and aids in improving the efficacy of the new as well as old drugs and has the potential in crossing the various physiological barriers and also improves the therapeutic index of the drugs and increases the patient compliance. The objectives of this review is to classify the nanoparticles based on the different groups, surface properties of nanoparticles, describe the strategies of drug targeting, the necessity of nanoparticles their general method of preparation, different methods used in characterization, self- assembly and mechanism of drug release in a systemic manner. The potential advantages and limitations of various nanoparticulate drug delivery systems are also discussed elaborately.

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