scholarly journals Maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age: a prospective cohort study from the Japan Environment and Children's Study (JECS)

2021 ◽  
Author(s):  
Kunio Miyake ◽  
Megumi Kushima ◽  
Ryoji Shinohara ◽  
Sayaka Horiuchi ◽  
Sanae Otawa ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Maternal Smoking ◽  
Smoking Status ◽  
Multivariate Logistic Regression Analysis ◽  
Smoking During Pregnancy ◽  
Established Risk Factor ◽  
Smoking Exposure ◽  
Increased Risk ◽  
Maternal Smoking During Pregnancy ◽  
Prenatal Maternal Smoking

Abstract Background Maternal smoking exposure during pregnancy is an established risk factor for childhood asthma, but the association between maternal pre-pregnancy smoking status and asthma risk is not well understood. This study examined the association between maternal smoking status before and during pregnancy and bronchial asthma at 3 years of age. Methods The data of 75,411 mother-child pairs, excluding the missing data of exposure and outcomes from the Japan Environment and Children's Study (JECS) were used. The association between prenatal maternal smoking status and the risk of bronchial asthma at 3 years of age was determined using multivariate logistic regression analysis. Results The percentage of 3-year-old children with doctor-diagnosed bronchial asthma was 7.2%. The distribution of maternal smoking status before childbirth was as follows: Never = 60.0%, Quit before recognizing current pregnancy = 24.1%, Quit after finding out current pregnancy = 12.3%, and Still smoking = 3.6%. Maternal smoking during pregnancy was significantly associated with an increased risk of bronchial asthma at 3 years of age even after adjusting for pre- and postnatal covariates (adjusted odds ratio [aOR] 1.35, 95% confidence interval [CI] 1.16–1.57). Furthermore, mothers who quit before recognizing current pregnancy (aOR 1.10, 95% CI 1.02–1.18) or who quit after finding out about current pregnancy (aOR 1.11, 95% CI 1.01–1.23) were also significantly associated. Conclusions This study suggested that not only maternal smoking during pregnancy but also maternal smoking exposure of pre-pregnancy or early pregnancy may be associated with an increased risk of bronchial asthma in children.

Contribution of prenatal factors and in formation of asthma phenotypes in children (part I)

2016 ◽  
Vol 7 (2) ◽  
pp. 47-56 ◽  
Author(s):  
Liudmila A Zhelenina ◽  
Anna N Galustyan ◽  
Natalya B Platonova ◽  
Mariya V Kuropatenko
Keyword(s):  
Risk Factors ◽  
Bronchial Asthma ◽  
Maternal Smoking ◽  
Significant Risk ◽  
Low Frequency ◽  
Asthma Phenotype ◽  
Smoking During Pregnancy ◽  
Asthma Phenotypes ◽  
Maternal Smoking During Pregnancy ◽  
Hyperimmunoglobulinemia E

Results of the prospective study conducted to assess the perinatal risk factors contribution in the asthma phenotypes formation in childhood are presented. Of 712 children, which have been observed from the first wheezing onset in St Petersburg’s state ambulances, 238 children with bronchial asthma developed in later years of life were included in random sample. Bronchial asthma proceeded in the structure of atopic disease in 128 children (phenotype ABA), and as the part of the limited allergic lesion of respiratory tract - in 110 children (phenotype RBA). It was found that bronchial asthma in mother, especially mother’s asthma with the early age onset, pregnancy pathology and maternal Smoking during pregnancy are the most significant risk factors which contribute in formation of ABA asthma phenotype. Maternal Smoking during pregnancy increased the frequency of severe asthma with ABA phenotype in the offspring during next years of their life. Clinically, the ABA phenotype is characterized by more frequent debut at the age of 1 year and usually diagnosed before 7 years of age, the presence of food sensitization in 70-90 % of cases, and a high level of hyperimmunoglobulinemia E. Such triggers as the Cesarean delivery, absence of the breastfeeding and exposure to tobacco products in the first years of life are the most significant risk factors in formation of the RBA asthma phenotype. The absence of allergic diseases in both parents or allergic ллерголог in mothers, later age debut and diagnosis of asthma, extremely low frequency of food sensibilization (less than 15 %), high frequency of hyperresponsivity, and low frequency of hyperimmunoglobulinemia E, exceeds the norm in 2 times are the typical features of RBA asthma phenotype.

scholarly journals DNA methylation links prenatal smoking exposure to later life health outcomes in offspring

2018 ◽  
Author(s):  
Petri Wiklund ◽  
Ville Karhunen ◽  
Rebecca C Richmond ◽  
Alina Rodriguez ◽  
Maneka De Silva ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Health Outcomes ◽  
Maternal Smoking ◽  
Psychiatric Morbidity ◽  
Later Life ◽  
Prenatal Smoking ◽  
Smoking During Pregnancy ◽  
Mediation Analyses ◽  
Increased Risk ◽  
Prenatal Maternal Smoking

AbstractMaternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship. To test this, we examined the association of prenatal maternal smoking with DNA methylation in 2,821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess, whether methylation markers have causal effects on disease outcomes in the offspring. We identify 69 differentially methylated CpGs in 36 genomic regions (P < 1×10−7), and show that DNA methylation may represent a biological mechanism through which maternal smoking is associated with increased risk of psychiatric morbidity in the exposed offspring.

Maternal Smoking During Pregnancy and ADHD: Results From a Systematic Review and Meta-Analysis of Prospective Cohort Studies

2017 ◽  
Vol 24 (12) ◽  
pp. 1637-1647 ◽  
Author(s):  
Yan He ◽  
Jian Chen ◽  
Li-Hua Zhu ◽  
Ling-Ling Hua ◽  
Fang-Fang Ke
Keyword(s):  
Cohort Studies ◽  
Prospective Cohort ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Smoking During Pregnancy ◽  
Prospective Cohort Studies ◽  
Relative Risks ◽  
Increased Risk ◽  
Quitting Smoking ◽  
Maternal Smoking During Pregnancy

Objective: Findings on maternal smoking during pregnancy and ADHD risk in children are inconsistent. A meta-analysis was performed to summarize effects of exposure to maternal smoking during pregnancy on ADHD risk in children. Method: We conducted a systematic literature search to select articles up to June 2016. Only prospective cohort studies were included. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated. Results: Pooled RR estimates based on 12 cohort studies including 17,304 pregnant women suggested that maternal smoking during pregnancy was associated with an increased risk of ADHD (pooled RR = 1.58, 95% CI = [1.33, 1.88]). Conclusion: Results from this study indicate that maternal smoking during pregnancy is related to an increased risk of ADHD in children. There is an urgent need to increase maternal awareness of smoking risk and quitting smoking to mitigate the ADHD risk in children.

Familial confounding of the association between maternal smoking during pregnancy and internalizing disorders in offspring

2017 ◽  
Vol 47 (8) ◽  
pp. 1417-1426 ◽  
Author(s):  
S. M. Meier ◽  
K. J. Plessen ◽  
F. Verhulst ◽  
O. Mors ◽  
P. B. Mortensen ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Maternal Smoking ◽  
Depressive Disorders ◽  
Cox Regression ◽  
Severe Depression ◽  
Internalizing Disorders ◽  
Externalizing Disorders ◽  
Smoking During Pregnancy ◽  
Increased Risk ◽  
Maternal Smoking During Pregnancy

BackgroundMaternal smoking has consistently been associated with multiple adverse childhood outcomes including externalizing disorders. In contrast the association between maternal smoking during pregnancy (MSDP) and internalizing (anxiety and depressive) disorders in offspring has received less investigation.MethodWe conducted a nationwide cohort study including 957635 individuals born in Denmark between 1991 and 2007. Data on MSDP and diagnoses of depression or anxiety disorders were derived from national registers and patients were followed up from the age of 5 years to the end of 2012. Hazard rate ratios (HRRs) were estimated using stratified Cox regression models. Sibling data were used to disentangle individual- and familial-level effects of MSDP and to control for unmeasured familial confounding.ResultsAt the population level, offspring exposed to MSDP were at increased risk for both severe depression [HRR 1.29, 95% confidence interval (CI) 1.22–1.36] and severe anxiety disorders (HRR 1.26, 95% CI 1.20–1.32) even when controlling for maternal and paternal traits. However, there was no association between MSDP and internalizing disorders when controlling for the mother's propensity for MSDP (depression: HRR 1.11, 95% CI 0.94–1.30; anxiety disorders: HRR 0.94, 95% CI 0.80–1.11) or comparing differentially exposed siblings (depression: HRR 1.18, 95% CI 0.75–1.89; anxiety disorders: HRR 0.87, 95% CI 0.55–1.36).ConclusionsThe results suggest that familial background factors account for the association between MSDP and severe internalizing disorders not the specific exposure to MSDP.

Maternal smoking during pregnancy, offspring smoking, adverse childhood events, and risk of major depression: a sibling design study

2021 ◽  
pp. 1-11
Author(s):  
Edmond D. Shenassa ◽  
Michelle L. Rogers ◽  
Stephen L. Buka
Keyword(s):  
Maternal Smoking ◽  
Smoking Status ◽  
Human Studies ◽  
Smoking During Pregnancy ◽  
Adverse Childhood Events ◽  
Adverse Childhood ◽  
Binomial Regression ◽  
Maternal Smoking During Pregnancy ◽  
Independent Association ◽  
Risk Ratios

Abstract Background Evidence of a biologically plausible association between maternal smoking during pregnancy (MSP) and the risk of depression is discounted by null findings from two sibling studies. However, valid causal inference from sibling studies is subject to challenges inherent to human studies of MSP and biases particular to this design. We addressed these challenges in the first sibling study of MSP and depression conducted among adults past the peak age for the onset of depression, utilizing a prospectively collected and biologically validated measure of MSP and accounting for non-shared as well as mediating factors. Methods We fit GEE binomial regression models to correct for dependence in the risk of depression across pregnancies of the same mother. We also fit marginal structural models (MSM) to estimate the controlled direct effect of MSP on depression that is not mediated by the offspring's smoking status. Both models allow the estimation of within- and between-sibling risk ratios. Results The adjusted within-sibling risk ratios (RRW) from both models (GEE: RRW = 1.97, CI 1.16–3.32; MSM: RRW = 2.08, CI 1.04–4.17) evinced an independent association between MSP and risk of depression. The overall effects from a standard model evinced lower associations (GEE: RRT = 1.12, CI 0.98–1.28; MSM: RRT = 1.18, CI 1.01–1.37). Conclusions Based on within-sibling information free of unmeasured shared confounders and accounting for a range of unshared factors, we found an effect of MSP on the offspring's risk of depression. Our findings, should they be replicated in future studies, highlight the importance of considering challenges inherent to human studies of MSP and affective disorders.

scholarly journals 889Association of maternal smoking during pregnancy and early-childhood with adult insomnia symptoms

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Yohannes Adama Melaku ◽  
Sarah Appleton ◽  
Amy Reynolds ◽  
Tiffany Gill ◽  
Alexander M Sweetman ◽  
...  
Keyword(s):  
Early Childhood ◽  
Maternal Smoking ◽  
Birth Cohort Study ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Smoking During Pregnancy ◽  
Increased Risk ◽  
Maternal Smoking During Pregnancy ◽  
The Uk ◽  
Insomnia Symptoms

Abstract Background Evidence regarding the association between perinatal smoking and insomnia symptoms in adulthood is limited. Using the UK 1970 Birth Cohort Study, we determined the association of maternal smoking during pregnancy and early-childhood with insomnia symptoms at 42 years. Methods Participants were followed from birth (1970; N = 9020; male, 48%) and age 5 (1975; N = 8050; male, 47.9%) to 42 years (2012). Data on maternal smoking was collected at birth and age 5; difficulties initiating or maintaining sleep (DIMS) and DIMS plus daytime symptoms (tiredness, irritability, depression and nervousness) [DIMS plus] at age 42. We used a direct acyclic graph to select confounders. A log-binomial logistic regression, adjusted for confounders, was used to estimate the association. Missing data were imputed via multiple imputation. Results The prevalence of DIMS and DIMS plus was 32% and 25%, respectively. There was a 25% [odds ratio (OR)=1.25; 95% confidence interval (CI): 1.12-1.38)] and 23% [OR = 1.23; 95% CI: 1.09-1.38] increase in odds of DIMS and DIMS plus among participants whose mothers smoked during pregnancy compared to those whose mother did not. A 24% [OR = 1.24; 95% CI: 1.12-1.37] and 18% [OR = 1.18; 95% CI: 1.05-1.33] increase in odds of DIMS and DIMS plus respectively, was observed among participants who had smoking mothers at age 5. Intensity and duration of smoking had a dose-response relationship with insomnia symptoms. Conclusions Maternal smoking during pregnancy and early-childhood is associated with increased risk of adult insomnia symptoms. Key messages This study suggests that reducing maternal smoking may reduce the risk of adult insomnia.

Maternal Smoking during Pregnancy and the Risk for Childhood Infectious Diseases in the Offspring: A Population-Based Cohort Study

2019 ◽  
Author(s):  
Nadav Dan ◽  
Eyal Sheiner ◽  
Tamar Wainstock ◽  
Kyla Marks ◽  
Roy Kessous
Keyword(s):  
Infectious Diseases ◽  
Maternal Smoking ◽  
Cohort Analysis ◽  
Population Based ◽  
Upper Respiratory Tract ◽  
Smoking During Pregnancy ◽  
Infectious Morbidity ◽  
Increased Risk ◽  
Maternal Smoking During Pregnancy

Objective Infectious diseases account for up to 43% of childhood hospitalizations. Given the magnitude of infection-related hospitalizations, we aimed to evaluate the effect of maternal smoking during pregnancy on the risk for long-term childhood infectious morbidity. Study Design This is a population-based cohort analysis comparing the long-term risk for infectious diseases, in children born to mothers who smoked during pregnancy versus those who did not. Infectious diseases were predefined based on International Classification of Diseases, Ninth Revision codes. Deliveries occurred between the years 1991 and 2014. Results A total of 246,854 newborns met the inclusion criteria; 2,986 (1.2%) were born to mothers who smoked during pregnancy. Offspring of smokers had significantly higher risk for several infectious diseases during childhood (upper respiratory tract, otitis, viral infections, and bronchitis) as well as increased risk for total infection-related hospitalizations (odds ratio = 1.5, 95% confidence interval [CI]: 1.3–1.7; p = 0.001). Cumulative incidence of infection-related hospitalizations was significantly higher in offspring of smokers (log-rank test, p = 0.001). Controlling for maternal age, diabetes, hypertensive disorders, and gestational age at index delivery, smoking remained an independent risk factor for infectious diseases during childhood (adjusted hazard ratio = 1.5, 95% CI: 1.3–1.6; p = 0.001). Conclusion Intrauterine exposure to maternal smoking may create an environment leading to an increased future risk for long-term pediatric infectious morbidity of the offspring.

Maternal smoking during pregnancy and offpsring's psychiatric morbidity in early adulthood. Findings from the Finnish Family Competence Birth Cohort Study

2016 ◽  
Vol 33 (S1) ◽  
pp. S73-S73
Author(s):  
S. Niemelä ◽  
S. Mikola ◽  
A. Sourander ◽  
P. Rautava ◽  
M. Sillanpää
Keyword(s):  
Maternal Smoking ◽  
Psychiatric Morbidity ◽  
Early Adulthood ◽  
Education Level ◽  
Birth Cohort Study ◽  
Prenatal Smoking ◽  
Psychiatric Diagnoses ◽  
Smoking During Pregnancy ◽  
Smoking Exposure ◽  
Maternal Smoking During Pregnancy

IntroductionPrenatal smoking exposure is one of the most common insults during the fetal period prevalence varying from 5 to 19% in the European countries [1].ObjectivesPrenatal smoking exposure increases the risk of psychiatric morbidity in the offspring, externalizing disorders in particular. However, less is known whether maternal smoking during pregnancy increases the risk for anxiety disorders [1].AimsTo study the associations between maternal smoking during pregnancy and offspring psychiatric morbidity in early adulthood in a Finnish birth cohort study.MethodsA prospective data collection from 10th gestational week (GW10) to early adulthood (n = 475, 37% from the original sample). Information on self-reported smoking during pregnancy was collected using questionnaires at GW10 and GW28. Offspring psychiatric diagnoses and clinically relevant symptoms were assessed using Development and Well-being Assessment (DAWBA)-interviews at age 18 to 20 years. Information on parental alcohol use, depressive mood, anxiety, and education level, as well as offspring's gender, education level, and birth weight were used as covariates.ResultsMaternal smoking during pregnancy associated independently associated with PTSD (OR = 6.9, 95% CI 1.3–35.6, P = 0.021), and conduct disorder (OR = 2.7, 95% CI 1.02–6.9, P = 0.046) in a multivariate analysis after adjusting for other psychiatric diagnoses, offspring and parental variables (OR = 1.9, 95% CI 0.5–6.9, P = 0.359).ConclusionsIn addition to conduct problems, prenatal nicotine exposure may increase the offspring's risk for posttraumatic stress disorder (PTSD). This relationship may be explained, in part, by effects on nicotinic acetylcholine receptors and uteroplacental mechanisms [1].Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Associations of prenatal maternal smoking with offspring hyperactivity: causal or confounded?

2013 ◽  
Vol 44 (4) ◽  
pp. 857-867 ◽  
Author(s):  
K. M. Keyes ◽  
G. Davey Smith ◽  
E. Susser
Keyword(s):  
Maternal Smoking ◽  
Population Based ◽  
Similar Degree ◽  
Prenatal Smoking ◽  
Tobacco Exposure ◽  
Smoking During Pregnancy ◽  
Pregnancy Cohort ◽  
Smoking Exposure ◽  
Prenatal Maternal Smoking ◽  
Paternal Smoking

BackgroundThe relationship between prenatal tobacco exposure and hyperactivity remains controversial. To mitigate limitations of prior studies, we used a strategy involving comparison of maternal and paternal smoking reports in a historical sample where smoking during pregnancy was common.MethodData were drawn from a longitudinally followed subsample of the Child Health and Development Study (n = 1752), a population-based pregnancy cohort ascertained in 1961–1963 in California. Maternal prenatal smoking was common (33.4%). Maternal and paternal smoking patterns were assessed at three time points by mother report. Hyperactivity was assessed at the mean of age of 10 years based on mother report to a personality inventory.ResultsUnadjusted, maternal smoking during pregnancy was associated with offspring hyperactivity [β = 0.22, 95% confidence interval (CI) 0.11–0.33] and, to a similar degree, when the father smoked (β = 0.18, 95% CI 0.07–0.30). After adjustment, maternal smoking remained robustly predictive of offspring hyperactivity (β = 0.25, 95% CI 0.09–0.40) but father smoking was not (β = 0.02, 95% CI −0.20 to 0.24). When examined among the pairs matched on propensity score, mother smoking was robustly related to offspring hyperactivity whether the father smoked (β = 0.26, 95% CI 0.03–0.49) or did not smoke (β = 0.30, 95% CI 0.04–0.57). By number of cigarettes, associations with hyperactivity were present for 10–19 and 20+ cigarettes per day among mothers.ConclusionsIn a pregnancy cohort recruited in a time period in which smoking during pregnancy was common, we document associations between prenatal smoking exposure and offspring hyperactivity. Novel approaches to inferring causality continue to be necessary in describing the potential adverse consequences of prenatal smoking exposure later in life.

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