P/CAF Function in Transcriptional Activation by Steroid Hormone Receptors and Mammary Cell Proliferation

2000 ◽  
Author(s):  
Sharon Y. Roth
Keyword(s):  
Cell Proliferation ◽  
Transcriptional Activation ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Mammary Cell

Characteristics of steroid hormone receptors in cultured MC3T3-E1 osteoblastic cells and effect of steroid hormones on cell proliferation

1992 ◽  
Vol 51 (5) ◽  
pp. 376-381 ◽  
Author(s):  
Akihiro Masuyama ◽  
Yasuyoshi Ouchi ◽  
Fumiyasu Sato ◽  
Takyauki Hosoi ◽  
Tetsuro Nakamura ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Steroid Hormones ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Osteoblastic Cells

scholarly journals Isoform-Specific Transcriptional Regulation by Thyroid Hormone Receptors: Hormone-Independent Activation Operates through a Steroid Receptor Mode of Coactivator Interaction

2001 ◽  
Vol 15 (7) ◽  
pp. 1170-1185 ◽  
Author(s):  
Zhihong Yang ◽  
Martin L. Privalsky
Keyword(s):  
Thyroid Hormone ◽  
Transcriptional Activation ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Expression Patterns ◽  
Steroid Receptor ◽  
Steroid Hormone Receptors ◽  
Thyroid Hormone Receptors ◽  
Interaction Domain ◽  
Specific Expression

Abstract Thyroid hormone receptors (T3Rs) are hormone-regulated transcription factors that play important roles in vertebrate homeostasis, differentiation, and development. T3Rs are synthesized as multiple isoforms that display tissue-specific expression patterns and distinct transcriptional properties. Most T3R isoforms associate with coactivator proteins and mediate transcriptional activation only in the presence of thyroid hormone. The pituitary-specific T3Rβ-2 isoform departs from this general rule and is able to interact with p160 coactivators, and to mediate transcriptional activation in both the absence and presence of hormone. We report here that this hormone-independent activation is mediated by contacts between the unique N terminus of T3Rβ-2 and an internal interaction domain in the SRC-1 (steroid receptor coactivator-1) and GRIP-1 (glucocorticoid receptor interacting protein 1) coactivators. These hormone-independent contacts between T3Rβ-2 and the p160 coactivators are distinct in sequence and function from the LXXLL motifs that mediate hormone-dependent transcriptional activation and resemble instead a mode of coactivator recruitment previously observed only for the steroid hormone receptors and only in the presence of steroid hormone. Our results suggest that the transcriptional properties of the different T3R isoforms represent a combinatorial mixture of repression, antirepression, and hormone-independent and hormone-dependent activation functions that operate in conjunction to determine the ultimate transcriptional outcome.

Protein p53 expression, cell proliferation and steroid hormone receptors in ductal carcinoma in situ of the breast

1997 ◽  
Vol 29 (3) ◽  
pp. 126-131
Author(s):  
Angelika Reiner ◽  
Margaretha Rudas ◽  
Renate Neumayer ◽  
M. F. X. Gnant ◽  
Martina Mittlböck ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Hormone Receptors ◽  
Ductal Carcinoma ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
P53 Expression ◽  
Protein P53

Physical exercise on the rat ventral prostate: Steroid hormone receptors, apoptosis and cell proliferation

2012 ◽  
Vol 22 (5) ◽  
pp. e86-e92 ◽  
Author(s):  
G. R. Teixeira ◽  
W. J. Fávaro ◽  
P. F. F. Pinheiro ◽  
L. G. A. Chuffa ◽  
J. P. A. Amorim ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Physical Exercise ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Steroid Hormone Receptors ◽  
Ventral Prostate ◽  
Rat Ventral Prostate
Sign in / Sign up

Export Citation Format

Share Document