Collection of Prostate Cancer Families and Mapping Additional Hereditary Prostate Cancer Genes (HPC2, HPC3,...)

2000 ◽  
Author(s):  
William B. Isaacs
Keyword(s):  
Prostate Cancer ◽  
Cancer Genes ◽  
Hereditary Prostate Cancer

Abstract B40: Rare variant discovery in known cancer genes from whole-exome sequencingof African American hereditary prostate cancer families

2016 ◽  
Author(s):  
Cheryl D. Cropp ◽  
Shannon K. McDonnell ◽  
Sumit Middha ◽  
Melissa DeRycke ◽  
Danielle M. Karyadi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Rare Variant ◽  
Cancer Genes ◽  
Hereditary Prostate Cancer ◽  
Variant Discovery ◽  
Whole Exome

Abstract A69: Identification of prostate cancer genes in the African American Hereditary Prostate Cancer (AAHPC) study

2011 ◽  
Author(s):  
Luisel J. Ricks-Santi ◽  
Tshela Mason ◽  
Muneer Abbas ◽  
Georgia M. Dunston ◽  
Supraja Kolluri ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Cancer Genes ◽  
Hereditary Prostate Cancer

scholarly journals Hereditary Prostate Cancer: Genes Related, Target Therapy and Prevention

2021 ◽  
Vol 22 (7) ◽  
pp. 3753
Author(s):  
Maria Teresa Vietri ◽  
Giovanna D’Elia ◽  
Gemma Caliendo ◽  
Marianna Resse ◽  
Amelia Casamassimi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Synthetic Lethality ◽  
Current Knowledge ◽  
Target Therapy ◽  
Parp Inhibitors ◽  
Cancer Type ◽  
Cancer Genes ◽  
Therapeutic Implications ◽  
Hereditary Prostate Cancer ◽  
Mmr Genes

Prostate cancer (PCa) is globally the second most diagnosed cancer type and the most common cause of cancer-related deaths in men. Family history of PCa, hereditary breast and ovarian cancer (HBOC) and Lynch syndromes (LS), are among the most important risk factors compared to age, race, ethnicity and environmental factors for PCa development. Hereditary prostate cancer (HPCa) has the highest heritability of any major cancer in men. The proportion of PCa attributable to hereditary factors has been estimated in the range of 5–15%. To date, the genes more consistently associated to HPCa susceptibility include mismatch repair (MMR) genes (MLH1, MSH2, MSH6, and PMS2) and homologous recombination genes (BRCA1/2, ATM, PALB2, CHEK2). Additional genes are also recommended to be integrated into specific research, including HOXB13, BRP1 and NSB1. Importantly, BRCA1/BRCA2 and ATM mutated patients potentially benefit from Poly (ADP-ribose) polymerase PARP inhibitors, through a mechanism of synthetic lethality, causing selective tumor cell cytotoxicity in cell lines. Moreover, the detection of germline alterations in MMR genes has therapeutic implications, as it may help to predict immunotherapy benefits. Here, we discuss the current knowledge of the genetic basis for inherited predisposition to PCa, the potential target therapy, and the role of active surveillance as a management strategy for patients with low-risk PCa. Finally, the current PCa guideline recommendations are reviewed.

Hereditary prostate cancer

2001 ◽  
Vol 85 (5) ◽  
pp. 611-613 ◽  
Author(s):  
O. Bratt
Keyword(s):  
Prostate Cancer ◽  
Hereditary Prostate Cancer

scholarly journals Prostate cancer risk variants of the HOXB genetic locus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
William D. Dupont ◽  
Joan P. Breyer ◽  
Spenser H. Johnson ◽  
W. Dale Plummer ◽  
Jeffrey R. Smith
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Cancer Genetics ◽  
Genetic Locus ◽  
Familial Cancer ◽  
Prostate Cancer Risk ◽  
European Ancestry ◽  
Ovarian Cancer Screening ◽  
Hereditary Prostate Cancer ◽  
Aggressive Disease

AbstractThe G84E germline mutation of HOXB13 predisposes to prostate cancer and is clinically tested for familial cancer care. We investigated the HOXB locus to define a potentially broader contribution to prostate cancer heritability. We sought HOXB locus germline variants altering prostate cancer risk in three European-ancestry case–control study populations (combined 7812 cases and 5047 controls): the International Consortium for Prostate Cancer Genetics Study; the Nashville Familial Prostate Cancer Study; and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Multiple rare genetic variants had concordant and strong risk effects in these study populations and exceeded genome-wide significance. Independent risk signals were best detected by sentinel variants rs559612720 within SKAP1 (OR = 8.1, P = 2E−9) and rs138213197 (G84E) within HOXB13 (OR = 5.6, P = 2E−11), separated by 567 kb. Half of carriers inherited both risk alleles, while others inherited either alone. Under mutual adjustment, the variants separately carried 3.6- and 3.1-fold risk, respectively, while joint inheritance carried 11.3-fold risk. These risks were further accentuated among men meeting criteria for hereditary prostate cancer, and further still for those with early-onset or aggressive disease. Among hereditary prostate cancer cases diagnosed under age 60 and with aggressive disease, joint inheritance carried a risk of OR = 27.7 relative to controls, P = 2E−8. The HOXB sentinel variant pair more fully captured genetic risk for prostate cancer within the study populations than either variant alone.

Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)

The Prostate ◽  
2006 ◽  
Vol 67 (1) ◽  
pp. 22-31 ◽  
Author(s):  
Agnes B. Baffoe-Bonnie ◽  
Rick A. Kittles ◽  
Elizabeth Gillanders ◽  
Liang Ou ◽  
Asha George ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Cancer Study ◽  
Hereditary Prostate Cancer ◽  
Genome Wide ◽  
Prostate Cancer Study
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