Hereditary prostate cancer

2001 ◽  
Vol 85 (5) ◽  
pp. 611-613 ◽  
Author(s):  
O. Bratt
Keyword(s):  
Prostate Cancer ◽  
Hereditary Prostate Cancer

scholarly journals Prostate cancer risk variants of the HOXB genetic locus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
William D. Dupont ◽  
Joan P. Breyer ◽  
Spenser H. Johnson ◽  
W. Dale Plummer ◽  
Jeffrey R. Smith
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Cancer Genetics ◽  
Genetic Locus ◽  
Familial Cancer ◽  
Prostate Cancer Risk ◽  
European Ancestry ◽  
Ovarian Cancer Screening ◽  
Hereditary Prostate Cancer ◽  
Aggressive Disease

AbstractThe G84E germline mutation of HOXB13 predisposes to prostate cancer and is clinically tested for familial cancer care. We investigated the HOXB locus to define a potentially broader contribution to prostate cancer heritability. We sought HOXB locus germline variants altering prostate cancer risk in three European-ancestry case–control study populations (combined 7812 cases and 5047 controls): the International Consortium for Prostate Cancer Genetics Study; the Nashville Familial Prostate Cancer Study; and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Multiple rare genetic variants had concordant and strong risk effects in these study populations and exceeded genome-wide significance. Independent risk signals were best detected by sentinel variants rs559612720 within SKAP1 (OR = 8.1, P = 2E−9) and rs138213197 (G84E) within HOXB13 (OR = 5.6, P = 2E−11), separated by 567 kb. Half of carriers inherited both risk alleles, while others inherited either alone. Under mutual adjustment, the variants separately carried 3.6- and 3.1-fold risk, respectively, while joint inheritance carried 11.3-fold risk. These risks were further accentuated among men meeting criteria for hereditary prostate cancer, and further still for those with early-onset or aggressive disease. Among hereditary prostate cancer cases diagnosed under age 60 and with aggressive disease, joint inheritance carried a risk of OR = 27.7 relative to controls, P = 2E−8. The HOXB sentinel variant pair more fully captured genetic risk for prostate cancer within the study populations than either variant alone.

Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer Study (AAHPC)

The Prostate ◽  
2006 ◽  
Vol 67 (1) ◽  
pp. 22-31 ◽  
Author(s):  
Agnes B. Baffoe-Bonnie ◽  
Rick A. Kittles ◽  
Elizabeth Gillanders ◽  
Liang Ou ◽  
Asha George ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Cancer Study ◽  
Hereditary Prostate Cancer ◽  
Genome Wide ◽  
Prostate Cancer Study

Low frequency of allelic imbalance at the prostate cancer susceptibility lociHPC1 and 1p36 in Swedish men with hereditary prostate cancer

2000 ◽  
Vol 29 (4) ◽  
pp. 292-296 ◽  
Author(s):  
Anna-Karin �hman ◽  
Bj�rn-Anders Jonsson ◽  
Jan-Erik Damber ◽  
Anders Bergh ◽  
Monica Emanuelsson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Allelic Imbalance ◽  
Cancer Susceptibility ◽  
Low Frequency ◽  
Hereditary Prostate Cancer ◽  
Prostate Cancer Susceptibility

Hereditary Prostate Cancer in Germany

2001 ◽  
Vol 39 (Suppl. 4) ◽  
pp. 12-18 ◽  
Author(s):  
Thomas Paiss ◽  
Sylvia Bochum ◽  
Kathleen Herkommer ◽  
Christiane Maier ◽  
Katharina Roesch ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Hereditary Prostate Cancer

810 SCREENING FOR PROSTATE CANCER IN DUTCH HEREDITARY PROSTATE CANCER FAMILIES

2007 ◽  
Vol 6 (2) ◽  
pp. 225
Author(s):  
L.A. Kiemenev ◽  
M. Breeders ◽  
H. Vasen ◽  
P. Kil ◽  
J.A. Witjes
Keyword(s):  
Prostate Cancer ◽  
Hereditary Prostate Cancer

scholarly journals Clinical Features of Familial or Hereditary Prostate Cancer in Korean Men: A Pilot Study

2011 ◽  
Vol 52 (1) ◽  
pp. 9 ◽  
Author(s):  
Seung Hwan Lee ◽  
Kyung Kgi Park ◽  
Mun Su Chung ◽  
Byung Ha Chung
Keyword(s):  
Prostate Cancer ◽  
Pilot Study ◽  
Clinical Features ◽  
Hereditary Prostate Cancer

scholarly journals Family-based association analysis of 42 hereditary prostate cancer families identifies the Apolipoprotein L3 region on chromosome 22q12 as a risk locus

2010 ◽  
Vol 19 (19) ◽  
pp. 3852-3862 ◽  
Author(s):  
B. Johanneson ◽  
S. K. McDonnell ◽  
D. M. Karyadi ◽  
P. Quignon ◽  
L. McIntosh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Association Analysis ◽  
Hereditary Prostate Cancer ◽  
Risk Locus ◽  
Family Based

Germline copy number variation analysis in Finnish families with hereditary prostate cancer

The Prostate ◽  
2015 ◽  
Vol 76 (3) ◽  
pp. 316-324 ◽  
Author(s):  
Virpi H. Laitinen ◽  
Oyediran Akinrinade ◽  
Tommi Rantapero ◽  
Teuvo L.J. Tammela ◽  
Tiina Wahlfors ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Copy Number Variation ◽  
Copy Number ◽  
Variation Analysis ◽  
Hereditary Prostate Cancer ◽  
Copy Number Variation Analysis ◽  
Number Variation
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