New Approaches Towards the Elucidation of Epidermal-Dermal Separation in Sulfur Mustard-Exposed Human Skin and Directions For Therapy

2003 ◽  
Author(s):  
Marijke A. E. Mol
Keyword(s):  
Human Skin ◽  
Sulfur Mustard ◽  
New Approaches

Histopathologic and Immunohistochemical Features in Human Skin after Exposure to Nitrogen and Sulfur Mustard

1998 ◽  
Vol 20 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Kathleen J. Smith ◽  
William J. Smith ◽  
Tracey Hamilton ◽  
Henry G. Skelton ◽  
John S. Graham ◽  
...  
Keyword(s):  
Human Skin ◽  
Sulfur Mustard

Scanning and Transmission Electron Microscopic correlates of sulfur mustard (HD) toxicity

1989 ◽  
Vol 47 ◽  
pp. 1098-1099
Author(s):  
J.P. Petrali ◽  
S.B. Oglesby ◽  
K.R. Mills
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Guinea Pig ◽  
Human Skin ◽  
Sulfur Mustard ◽  
Pig Model ◽  
Transmission Electron ◽  
Hairless Guinea Pig ◽  
Guinea Pig Model ◽  
Scanning Electron

In spite of the many reports, since World War I no the pathology of mustard injury, no ultrastructural studies were performed until our laboratory published a report on the ultrastructure of the pathogenesis of blister formation following exposure to sulfur mustard of human–skin grafted to congenitally athymic nude mice. This study afforded us the opportunity for the first time to focus on several objectives: 1) to further delineate the histopathology which had been noted at light microscopy levels; 2) to identify possible early mustard-induced morpho- logical changes which may occur during the latent asynptcamtic phase; and 3) to prcmote our understanding of the temporal features of mustard pathology with the expectation that prophylactic and therapeutic strategies might be morphologically predictable. We now have the opportunity to describe HD-induced pathology in cells-in-culture and compare them with that of the skin lesion of a human skin grafted model and a hairless guinea pig model.We used standardized ultrastructural technology to study by transmission and scanning electron microscopy the subcellular effects of HD on human skin grafted to athymic mice, human lyrrphocytes and human keratinocytes in culture, and, the hairless guinea pig model. While doses of mustard differed according to the dictates of individualized protocols, all specimens were gathered at 24-48 hours following exposure and were aldehyde fixed, dehydrated in graded ethanols and either embedded in epoxy resin for transmission electron microscopy or critical-point dried and sputter coated with gold-palladium for scanning electron microscopy.

scholarly journals Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide

2010 ◽  
Vol 249 (2) ◽  
pp. 178-187 ◽  
Author(s):  
Adrienne T. Black ◽  
Patrick J. Hayden ◽  
Robert P. Casillas ◽  
Diane E. Heck ◽  
Donald R. Gerecke ◽  
...  
Keyword(s):  
Human Skin ◽  
Inflammatory Markers ◽  
Sulfur Mustard ◽  
Skin Equivalent ◽  
Full Thickness ◽  
Human Skin Equivalent

Morphologic Effects of Sulfur Mustard on a Human Skin Equivalent

1991 ◽  
Vol 10 (4) ◽  
pp. 315-324 ◽  
Author(s):  
John P. Petrau ◽  
Susan B. Oglesby ◽  
B.S. Tracey A. Justus
Keyword(s):  
Human Skin ◽  
Sulfur Mustard ◽  
Skin Equivalent ◽  
Human Skin Equivalent
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