The Roles of the Y Chromosome Genes in Prostate Cancer

2004 ◽  
Author(s):  
Yun-Fai C. Lau
Keyword(s):  
Prostate Cancer ◽  
Y Chromosome

Network-based approach reveals Y chromosome influences prostate cancer susceptibility

2014 ◽  
Vol 54 ◽  
pp. 24-31 ◽  
Author(s):  
Pegah Khosravi ◽  
Vahid H. Gazestani ◽  
Yazdan Asgari ◽  
Brian Law ◽  
Mehdi Sadeghi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Y Chromosome ◽  
Cancer Susceptibility ◽  
Prostate Cancer Susceptibility

Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer

2003 ◽  
Vol 101 (3-4) ◽  
pp. 250-260 ◽  
Author(s):  
Y.-F.C. Lau ◽  
H.W. Lau ◽  
L.G. Kömüves
Keyword(s):  
Prostate Cancer ◽  
Candidate Gene ◽  
Y Chromosome ◽  
Expression Pattern

scholarly journals Y chromosome haplogroups and prostate cancer in populations of European and Ashkenazi Jewish ancestry

2012 ◽  
Vol 131 (7) ◽  
pp. 1173-1185 ◽  
Author(s):  
Zhaoming Wang ◽  
Hemang Parikh ◽  
Jinping Jia ◽  
Timothy Myers ◽  
Meredith Yeager ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Y Chromosome ◽  
Ashkenazi Jewish ◽  
Jewish Ancestry

scholarly journals Loss of Y Chromosome in Peripheral Blood of Colorectal and Prostate Cancer Patients

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0146264 ◽  
Author(s):  
Predrag Noveski ◽  
Svetlana Madjunkova ◽  
Emilija Sukarova Stefanovska ◽  
Nadica Matevska Geshkovska ◽  
Maja Kuzmanovska ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Y Chromosome ◽  
Peripheral Blood

scholarly journals Y Chromosome Haplotypes and Prostate Cancer in Sweden

2008 ◽  
Vol 14 (20) ◽  
pp. 6712-6716 ◽  
Author(s):  
Sara Lindström ◽  
Hans-Olov Adami ◽  
Jan Adolfsson ◽  
Fredrik Wiklund
Keyword(s):  
Prostate Cancer ◽  
Y Chromosome

scholarly journals Prostate cancer incidence varies among males from different Y-chromosome lineages

2006 ◽  
Vol 9 (3) ◽  
pp. 303-309 ◽  
Author(s):  
A A Ewis ◽  
J Lee ◽  
T Naroda ◽  
T Sano ◽  
S Kagawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Y Chromosome ◽  
Cancer Incidence ◽  
Prostate Cancer Incidence

scholarly journals A SVM Model for Candidate Y-chromosome Gene Discovery in Prostate Cancer

10.29007/3nzw ◽  
2019 ◽  
Author(s):  
Wageesha Rasanjana ◽  
Sandun Rajapaksa ◽  
Indika Perera ◽  
Dulani Meedeniya
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Y Chromosome ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Support Vector ◽  
Body Tissues ◽  
Average Accuracy ◽  
To Come ◽  
Significant Expression

Prostate cancer is widely known to be one of the most common cancers among men around the world. Due to its high heterogeneity, many of the studies carried out to identify the molecular level causes for cancer have only been partially successful. Among the techniques used in cancer studies, gene expression profiling is seen to be one of the most popular techniques due to its high usage. Gene expression profiles reveal information about the functionality of genes in different body tissues at different conditions. In order to identify cancer-decisive genes, differential gene expression analysis is carried out using statistical and machine learning methodologies. It helps to extract information about genes that have significant expression differences between healthy tissues and cancerous tissues. In this paper, we discuss a comprehensive supervised classification approach using Support Vector Machine (SVM) models to investigate differentially expressed Y-chromosome genes in prostate cancer. 8 SVM models, which are tuned to have 98.3% average accuracy have been used for the analysis. We were able to capture genes like CD99 (MIC2), ASMTL, DDX3Y and TXLNGY to come out as the best candidates. Some of our results support existing findings while introducing novel findings to be possible prostate cancer candidates.

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