Transforming Growth Factor Beta Regulation of Tumor Progression in Metastatic Cancer

2004 ◽  
Author(s):  
Merry Jo Oursler
Keyword(s):  
Growth Factor ◽  
Tumor Progression ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Metastatic Cancer ◽  
Growth Factor Beta

scholarly journals Transforming Growth Factor-Beta and Urokinase-Type Plasminogen Activator: Dangerous Partners in Tumorigenesis—Implications in Skin Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-26 ◽  
Author(s):  
Juan F. Santibanez
Keyword(s):  
Growth Factor ◽  
Skin Cancer ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Upa System ◽  
Growth Factor Beta

Transforming growth factor-beta (TGF-β) is a pleiotropic factor, with several different roles in health and disease. TGF-β has been postulated as a dual factor in tumor progression, since it represses epithelial tumor development in early stages, whereas it stimulates tumor progression in advanced stages. During tumorigenesis, cancer cells acquire the capacity to migrate and invade surrounding tissues and to metastasize different organs. The urokinase-type plasminogen activator (uPA) system, comprising uPA, the uPA cell surface receptor, and plasminogen-plasmin, is involved in the proteolytic degradation of the extracellular matrix and regulates key cellular events by activating intracellular signal pathways, which together allow cancer cells to survive, thus, enhancing cell malignance during tumor progression. Due to their importance, uPA and its receptor are tightly transcriptionally regulated in normal development, but are deregulated in cancer, when their activity and expression are related to further development of cancer. TGF-β regulates uPA expression in cancer cells, while uPA, by plasminogen activation, may activate the secreted latent TGF-β, thus, producing a pernicious cycle which contributes to the enhancement of tumor progression. Here we review the specific roles and the interplay between TGF-β and uPA system in cancer cells and their implication in skin cancer.

603: Prostate Androgen Responsiveness Involve Stromal Transforming Growth Factor-Beta Signaling

2004 ◽  
Vol 171 (4S) ◽  
pp. 160-160
Author(s):  
Neil A. Bhowmick ◽  
Susan Kasper
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Growth Factor Beta

Transforming Growth Factor Beta (TGFβ) Gene Polymorphisms in Different Phenotypes of Sarcoidosis

Pneumologie ◽  
2010 ◽  
Vol 64 (S 03) ◽  
Author(s):  
S Pabst ◽  
T Fränken ◽  
J Schönau ◽  
D Skowasch ◽  
C Grohé
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Gene Polymorphisms ◽  
Transforming Growth Factor ◽  
Growth Factor Beta
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