A Partnership Training Program in Breast Cancer Diagnosis: Concept Development of the Next Generation Diagnostic Breast Imaging Using Digital Image Library and Networking Techniques

2004 ◽  
Author(s):  
Mohamed F. Chouikha
Keyword(s):  
Breast Cancer ◽  
Training Program ◽  
Cancer Diagnosis ◽  
Digital Image ◽  
Breast Imaging ◽  
Breast Cancer Diagnosis ◽  
Concept Development ◽  
Next Generation ◽  
Image Library

scholarly journals Exploring the Association between Demographic Factors and Breast Cancer Diagnosis at a Holistic Breast Imaging Clinic in Cairo, Egypt

2020 ◽  
Vol 4 (1) ◽  
pp. 7-12
Author(s):  
Hanan S. Gewefel ◽  
◽  
Sophia Michelen ◽  
Bodour Salhia ◽  
Iman Ewais ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Breast Imaging ◽  
Demographic Factors ◽  
Breast Cancer Diagnosis

scholarly journals Breast Cancer Diagnosis using Digital Image Segmentation Techniques

2016 ◽  
Vol 9 (28) ◽  
Author(s):  
Monica ◽  
Singh Sanjay Kumar ◽  
Agrawal Prateek ◽  
Madaan Vishu
Keyword(s):  
Breast Cancer ◽  
Image Segmentation ◽  
Cancer Diagnosis ◽  
Digital Image ◽  
Breast Cancer Diagnosis

scholarly journals Detection of TP53 and PIK3CA Mutations in Circulating Tumor DNA Using Next-Generation Sequencing in the Screening Process for Early Breast Cancer Diagnosis

2019 ◽  
Vol 8 (8) ◽  
pp. 1183 ◽  
Author(s):  
Rodriguez ◽  
Córdoba ◽  
Aranda ◽  
Álvarez ◽  
Vicioso ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Cancer Diagnosis ◽  
Breast Imaging ◽  
Breast Cancer Diagnosis ◽  
Circulating Tumor Dna ◽  
Sequencing Analysis ◽  
Pik3ca Mutations ◽  
Ctdna Analysis ◽  
Tumor Dna

Circulating tumor DNA (ctDNA) has emerged as a non-invasive “liquid biopsy” for early breast cancer diagnosis. We evaluated the suitability of ctDNA analysis in the diagnosis of early breast cancer after mammography findings, comparing PIK3CA and TP53 mutations between tumor biopsies and pre-biopsy circulating DNA. Matched plasma and frozen fresh tissue biopsies from patients with Breast Imaging-Reporting and Data System (BIRADS) 4c/5 mammography findings and subsequent diagnosis of primary breast cancer were analyzed using NGS TruSeq Custom Amplicon Low Input Panel (Illumina) and plasma SafeSEQ (Sysmex Inostics). The same plasma and tumor mutations were observed in eight of 29 patients (27.6%) with four in TP53 and five in PIK3CA mutations. Sequencing analysis also revealed four additional ctDNA mutations (three in TP53 and one in PIK3CA) previously not identified in three patients tissue biopsy. One of these patients had mutations in both genes. Age, tumor grade and size, immunohistochemical (IHC) subtype, BIRADS category, and lymph node positivity were significantly associated with the detectability of these blood tumor-derived mutations. In conclusion, ctDNA analysis could be used in early breast cancer diagnosis, providing critical clinical information to improve patient diagnosis.

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