Sodium Iodide Symporter Gene Transfer for Imaging and Ablation of Prostate Cancer

2005 ◽  
Author(s):  
Sissy M. Jhiang
Keyword(s):  
Prostate Cancer ◽  
Gene Transfer ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter

In vivo expression and function of the sodium iodide symporter following gene transfer in the MATLyLu rat model of metastatic prostate cancer

The Prostate ◽  
2002 ◽  
Vol 50 (3) ◽  
pp. 170-178 ◽  
Author(s):  
Krista M.D. La Perle ◽  
Daniel Shen ◽  
Tara L.F. Buckwalter ◽  
Bonnie Williams ◽  
Aaron Haynam ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Gene Transfer ◽  
Rat Model ◽  
Metastatic Prostate Cancer ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter ◽  
In Vivo Expression ◽  
And Function

scholarly journals A Preclinical Large Animal Model of Adenovirus-Mediated Expression of the Sodium–Iodide Symporter for Radioiodide Imaging and Therapy of Locally Recurrent Prostate Cancer

2005 ◽  
Vol 12 (5) ◽  
pp. 835-841 ◽  
Author(s):  
Roisin M. Dwyer ◽  
Stephen M. Schatz ◽  
Elizabeth R. Bergert ◽  
Rae M. Myers ◽  
Mary E. Harvey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Animal Model ◽  
Sodium Iodide ◽  
Large Animal Model ◽  
Large Animal ◽  
Sodium Iodide Symporter ◽  
Recurrent Prostate Cancer ◽  
Locally Recurrent

Dual-expressing adenoviral vectors encoding the sodium iodide symporter for use in noninvasive radiological imaging of therapeutic gene transfer

2006 ◽  
Vol 33 (3) ◽  
pp. 391-398 ◽  
Author(s):  
Gang Niu ◽  
Richard D. Anderson ◽  
Mark T. Madsen ◽  
Michael M. Graham ◽  
Larry W. Oberley ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Sodium Iodide ◽  
Adenoviral Vectors ◽  
Radiological Imaging ◽  
Sodium Iodide Symporter ◽  
Therapeutic Gene

scholarly journals Application of 188Rhenium as an Alternative Radionuclide for Treatment of Prostate Cancer after Tumor-Specific Sodium Iodide Symporter Gene Expression

2007 ◽  
Vol 92 (11) ◽  
pp. 4451-4458 ◽  
Author(s):  
Michael J. Willhauck ◽  
Bibi-Rana Sharif Samani ◽  
Franz-Josef Gildehaus ◽  
Ingo Wolf ◽  
Reingard Senekowitsch-Schmidtke ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Therapeutic Effect ◽  
Half Life ◽  
Sodium Iodide ◽  
Specific Antigen ◽  
Volume Reduction ◽  
Sodium Iodide Symporter ◽  
Nis Gene

Abstract Context: We reported recently the induction of iodide accumulation in prostate cancer cells (LNCaP) by prostate-specific antigen promoter-directed sodium iodide symporter (NIS) expression that allowed a significant therapeutic effect of 131iodine (131I). These data demonstrated the potential of the NIS gene as a novel therapeutic gene, although in some extrathyroidal tumors, therapeutic efficacy may be limited by rapid iodide efflux due to a lack of iodide organification. Objective: In the current study, we therefore studied the potential of 188rhenium (188Re), as an alternative radionuclide, also transported by NIS, with a shorter half-life and higher energy β-particles than 131I. Results: NIS-transfected LNCaP cells (NP-1) concentrated 8% of the total applied activity of 188Re as compared with 16% of 125I, which was sufficient for a therapeutic effect in an in vitro clonogenic assay. γ-Camera imaging of NP-1 cell xenografts in nude mice revealed accumulation of 8–16% injected dose (ID)/g 188Re (biological half-life 12.9 h), which resulted in a 4.7-fold increased tumor absorbed dose (450 mGy/MBq) for 188Re as compared with 131I. After application of 55.5 MBq 131I or 188Re, smaller tumors showed a similar average volume reduction of 86%, whereas in larger tumors volume reduction was significantly increased from 73% after 131I treatment to 85% after application of 188Re. Conclusion: Although in smaller prostate cancer xenografts both radionuclides seemed to be equally effective after prostate-specific antigen promoter-mediated NIS gene delivery, a superior therapeutic effect has been demonstrated for 188Re in larger tumors.

scholarly journals Noninvasive Imaging and Radiovirotherapy of Prostate Cancer Using an Oncolytic Measles Virus Expressing the Sodium Iodide Symporter

2009 ◽  
Vol 17 (12) ◽  
pp. 2041-2048 ◽  
Author(s):  
Pavlos Msaouel ◽  
Ianko D Iankov ◽  
Cory Allen ◽  
Ileana Aderca ◽  
Mark J Federspiel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Measles Virus ◽  
Sodium Iodide ◽  
Noninvasive Imaging ◽  
Sodium Iodide Symporter

scholarly journals A steep radioiodine dose response scalable to humans in sodium-iodide symporter (NIS)-mediated radiovirotherapy for prostate cancer

2012 ◽  
Vol 19 (12) ◽  
pp. 839-844 ◽  
Author(s):  
M A Trujillo ◽  
M J Oneal ◽  
S McDonough ◽  
R Qin ◽  
J C Morris
Keyword(s):  
Prostate Cancer ◽  
Dose Response ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter
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