scholarly journals EXPERIENCE OF SHORT-COURSE TREATMENT IN THOSE SUFFERING FROM MULTIPLE DRUG RESISTANT TUBERCULOSIS

2018 ◽  
Vol 96 (5) ◽  
pp. 36-41 ◽  
Author(s):  
A. A. Toktogonovа ◽  
Z. Dzh. Kyzаlаkovа ◽  
T. I. Petrenko ◽  
T. A. Kolpаkovа
Keyword(s):  
Standard Treatment ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Tuberculosis Patients ◽  
The Past ◽  
Resistant Tuberculosis ◽  
Short Course ◽  
Multiple Drug Resistant ◽  
Mdr Tb ◽  
Default Rate

The article presents the analysis of outcomes of short course treatment of tuberculosis patients with multiple drug resistance (MDR TB), which was twice shorter compared to standard treatment (9-12 months versus 20-14 months). The efficiency of short-course and standard treatment did not differ significantly in new MDR TB cases and those previously who had limited tuberculous lesions and received no therapy with second line drugs in the past (69.2% versus 68.2%), while the default rate was twice less (13.5% versus 27%, p = 0.03). Economic efficiency of treatment: costs of drugs for short-course treatment of MDR TB were 3 times lower compared to the standard one.

scholarly journals Short course treatment of pulmonary tuberculosis patients suffering from multiple drug resistance. The current situation and future perspectives

2021 ◽  
Vol 98 (12) ◽  
pp. 57-66
Author(s):  
A. E. Russkikh ◽  
D. M. Kutuzova ◽  
O. V. Lovacheva ◽  
A. G. Samoylova ◽  
I. A. Vasilyeva
Keyword(s):  
Multiple Drug Resistance ◽  
Term Treatment ◽  
Multiple Drug ◽  
Short Term ◽  
Short Term Treatment ◽  
Tuberculosis Patients ◽  
Treatment Regimens ◽  
Resistant Tuberculosis ◽  
Short Course ◽  
Multiple Drug Resistant

The article presents a review of 70 publications. It describes relevant data on drugs, timing, indications, efficacy, and safety of short-term treatment regimens for multiple drug resistant tuberculosis.

scholarly journals OTOTOXICITY IN MDR-TB PATIENTS ON CATEGORY-4 REGIMEN: A CASE REPORT

2020 ◽  
Vol 7 (2) ◽  
pp. 257-259
Author(s):  
Tanish Baqar ◽  
Sharique Ahmad ◽  
Silky Rai
Keyword(s):  
Case Report ◽  
Large Scale ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Medical Progress ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Mdr Tb

Multiple drug-resistant tuberculosis (MDR-TB) is a critical situation affecting adults as properly as children across the globe (1). To determine the incidence and risk factors associated with Multiple Drug Resistant Tuberculosis (MDR-TB) (2), we studied Ototoxicity on 18 culture confirmed MDR-TB patients in Eras' Lucknow Medical College and Hospital, Lucknow from September, 2019 to January, 2020. This case follows a well documented report of a patient describing an unusual and novel occurrence of ototoxicity when undergoing treatment concerning multiple drug resistance tuberculosis along with symptoms, signs, diagnosis, treatment and follow-up (3). For descriptive convenience, the patient will be classified as patient 1. The following case is the cornerstones of medical progress and provides many new ideas in medicine. Containing an extensive review of the relevant literature on the topic, the case report is a rapid short communication between busy clinicians who may not have time or resources to conduct large scale research.(4)

Synthesis and Anti-mycobacterium Study on Halo-substituted 2-aryl oxyacetohydrazones

2020 ◽  
Vol 16 (5) ◽  
pp. 618-628 ◽  
Author(s):  
Vijay J. Desale ◽  
Suraj N. Mali ◽  
Hemchandra K. Chaudhari ◽  
Maya C. Mali ◽  
Bapu R. Thorat ◽  
...  
Keyword(s):  
Uv Spectroscopy ◽  
Health Concern ◽  
Multiple Drug ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
H37rv Strain ◽  
Mdr Tb ◽  
Drug Regimens ◽  
Ft Ir ◽  
Mycobacteria Tuberculosis

Background: The treatment of multiple-drug-resistant tuberculosis (MDR-TB) with currently available marketed drugs remains a global health concern. The cases of resistant tuberculosis patients are increasing day by day. Objective: The objective of this study is to highlight the need of developing shorter, simpler and tolerable drug regimens. Methods: In the present study, we synthesized various halo-substituted 2-aryloxyacetohydrazones via a series of reactions from halo-substituted phenols. All the compounds were characterized by using various spectroscopic methods, such as NMR, FT-IR, UV spectroscopy, etc. Results: All the synthesized hydrazones showed theoretically good interactions with enzyme enoyl reductase (pdb id: 4tzk). All the synthesized compounds (5a-5o) showed moderate to good activity (3.125-100 μg/mL) against Mycobacteria tuberculosis, H37RV strain. Conclusion: Our results would pave a new way for the development of more effective Anti-TB agents in the future.

Analisis of budget costs with different treatment efficiencies of newly diagnosed tuberculosis patients with multiple drug resistant pathogen

2021 ◽  
Vol 9 (3) ◽  
pp. 5-10
Author(s):  
N.V. Kuznetsov ◽  
A.S. Lesonen ◽  
U.M. Markelov ◽  
E.D. Mikhailova
Keyword(s):  
Drug Resistance ◽  
Rapid Determination ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
Multiple Drug Resistant ◽  
Treatment Gaps ◽  
Mdr Tb ◽  
Polymerase Chain ◽  
The Republic

The article presents the results of predicting the dynamics of the spread of new cases of tuberculosis (TB) with multiple drug resistance (MDR) in the Republic of Karelia, as well as the costs of treating patients with tuberculosis, considering the different effectiveness of treatment. It has been demonstrated that while enhancing efficiency of treatment, due to the rapid determination of drug resistance by the method of polymerase chain reaction and a decrease in treatment gaps (using food kits), the effectiveness of treatment is significantly increased and the prevalence of MDR-TB decreases, which leads to significant budget savings.

scholarly journals EXPERIENCE OF TREATMENT OF MULTIPLE DRUG RESISTANT TUBERCULOSIS PATIENTS WITH BEDAQUILINE IN AMUR REGION

2018 ◽  
Vol 96 (6) ◽  
pp. 45-50 ◽  
Author(s):  
L. Yu. Tikhonova ◽  
V. V. Sokolova ◽  
I. A. Tarasyuk ◽  
A. M. Ekimenko ◽  
M. A. Cherenkova ◽  
...  
Keyword(s):  
Cardiac Toxicity ◽  
Previous Treatment ◽  
Amur Region ◽  
Multiple Drug ◽  
Tuberculosis Patients ◽  
Resistant Tuberculosis ◽  
Sputum Microscopy ◽  
Multiple Drug Resistant ◽  
Extensive Drug Resistance ◽  
Sputum Conversion

The article describes the safety and efficiency evaluation of chemotherapy regimens containing bedaquiline used in 23 tuberculosis patients with multiple and extensive drug resistance in Amur Region. Treatment with bedaquiline (24 weeks) and other anti-tuberculosis drugs was highly effective based on sputum conversion criteria: sputum microscopy – 86.7% (13/15; 95% CI 62.1-96.3%), culture ‒ 82.6%, (19/23; 95% CI 62.7-93.0%), and cavity healing ‒ 73.9% (17/23; 95% CI 53.6-87.5%), of them patients with previous treatment failure made 43.6% (10/23). The best outcomes were achieved in the patients with new tuberculosis and relapses. A satisfactory safety profile was demonstrated during this trial piloting chemotherapy regimens containing bedaquiline, no cardiac toxicity was registered.

scholarly journals Risk factors for multiple drug resistant tuberculosis relapses

2020 ◽  
Vol 98 (11) ◽  
pp. 21-26
Author(s):  
А. S. Аlliluev ◽  
O. V. Filinyuk ◽  
E. E. Shnayder ◽  
P. N. Golubchikov ◽  
D. E. Аmichba
Keyword(s):  
Risk Factors ◽  
Medical Center ◽  
Multiple Drug ◽  
Sputum Smear ◽  
Smear Microscopy ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Mdr Tb

The objective of the study: to identify risk factors for relapses in patients after the effective course of chemotherapy for multiple drug resistant tuberculosis (MDR TB). Subjects and methods. Medical files of 346 adult MDR TB patients were analyzed, they all had the effective treatment as per regimen IV in Tomsk Phthisiopulmonology Medical Center in 2009-2011. They were divided into 2 groups: Group 1 included 35 patients who developed a relapse of tuberculosis over the next 5 years; Group 2 consisted of 311 patients who had no relapse of the disease over the next 5 years. Results. The relapse rate in effectively treated MDR TB patients made 10.1% (35/346 patients). The following social factors contributed to higher chances of the relapse: retirement age (p = 0.045; OR = 2.86 [1.14-7.20]) and disability due to somatic diseases (p < 0.001; OR = 4.82 [2.13-10.90]); while biomedical factors were the following: HIV infection (OR = 19.19 [5.29-69.56]), mental illness (OR = 5.85 [2.27-15.03]), tobacco smoking (OR = 3.16 [1.08-9.20]). People with history of tuberculosis relapses (OR = 12.17 [4.19-35.34]) have higher chances of relapse, as well as those having the following characteristics of the tuberculosis disease during the effective chemotherapy course: destruction of lung tissue (OR = 7.48 [1.76-31.80]), positive results of sputum smear microscopy (OR = 2.91 [1.28-6.61]), persisting bacterial excretion (by culture) after 2 months of chemotherapy (OR = 4.98 [2.41-10.29]).

scholarly journals Machine Learning for Prediction of Relapses in Multiple Drug Resistant Tuberculosis Patients

2021 ◽  
Vol 99 (11) ◽  
pp. 27-34
Author(s):  
A. S. Аlliluev ◽  
O. V. Filinyuk ◽  
E. E. Shnаyder ◽  
S. V. Аksenov
Keyword(s):  
Machine Learning ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Gradient Boosting ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Mdr Tb

The objective of the study: to evaluate the possibility of using machine learning algorithms for prediction of relapses in multiple drug resistant tuberculosis (MDR TB) patients.Subjects and Methods. Сlinical, epidemiological, gender, sex, social, biomedical parameters and chemotherapy parameters were analyzed in 346 cured MDR TB patients. The tools of the scikit-learn library, Version 0.24.2 in the Google Colaboratory interactive cloud environment were used to build forecasting models.Results. Analysis of the characteristics of relapse prediction models in cured MDR TB patients using machine learning algorithms including decision tree, random forest, gradient boosting, and logistic regression using K-block stratified validation revealed high sensitivity (0.74 ± 0.167; 0.91 ± 0.17; 0.91 ± 0.14; 0.91 ± 0.16, respectively) and specificity (0.97 ± 0.03; 0.98 ± 0.02; 0.98 ± 0.02; 0.98 ± 0.02, respectively).Five main predictors of relapse in cured MDR-TB patients were identified: repeated courses of chemotherapy; length of history of tuberculosis; destructive process in the lungs; total duration of treatment less than 22 months; and use of less than five effective anti-TB drugs in the regimen of chemotherapy.

scholarly journals Treatment of multiple drug-resistant tuberculosis (MDR-TB) in Iran

2005 ◽  
Vol 9 (6) ◽  
pp. 317-322 ◽  
Author(s):  
Seyed Mehdi Mirsaeidi ◽  
Payam Tabarsi ◽  
Kaveh Khoshnood ◽  
Majid Valiollah Pooramiri ◽  
Ali Rowhani-Rahbar ◽  
...  
Keyword(s):  
Multiple Drug ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multiple Drug Resistant ◽  
Mdr Tb
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