scholarly journals Prevention of Acute Graft-Versus-Host Reaction after Allogeneic Unrelated Hematopoietic Stem Cell Transplantation: Comparison of Effectiveness of Treatment Regimens Based on Anti-Thymocyte Globulin and Cyclophosphamide

2016 ◽  
Vol 9 (4) ◽  
pp. 391-397
Author(s):  
OV Pirogova ◽  
◽  
IS Moiseev ◽  
EV Babenko ◽  
OA Slesarchuk ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
Hematopoietic Stem ◽  
Graft Versus Host ◽  
Treatment Regimens ◽  
Comparison Of Effectiveness ◽  
Acute Graft

scholarly journals Diagnosis and staging of ophthalmic manifestations of the graft-versus-host reaction after allogeneic hematopoietic stem cell transplantation

2021 ◽  
Vol 14 (3) ◽  
pp. 91-102
Author(s):  
Natal’ya V. Chistyakova
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Clinical Manifestations ◽  
Graft Versus Host Reaction ◽  
Host Reaction ◽  
Hematopoietic Stem ◽  
Graft Versus Host

Graft-versus-host reaction is a common complication of allogeneic hematopoietic stem cell transplantation. This condition develops in approximately 4070% of patients. Its most common clinical manifestations include xerotic keratoconjunctivitis and cicatricial conjunctivitis. It is important to correctly diagnose and classify the ocular condition after surgery. Ocular graft-versus-host reaction can present as either classic acute or chronic form, acute form with late onset or with overlap syndrome. It may lead to severe ocular surface disease, which can significantly decrease the quality of life and restrict daily activities of patients. It is thus important to monitor the ocular condition closely since with early diagnosis of the condition and timely treatment start, risks of irreversible damage could be diminished. This article is dedicated to modern criteria of diagnosis and staging of ocular graft-versus-host reaction.

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