scholarly journals Integrated Single-Cell Transcriptomics and Chromatin Accessibility Analysis Reveals Novel Regulators of Mammary Epithelial Cell Identity

2019 ◽  
Author(s):  
Nicholas Pervolarakis ◽  
Peng Sun ◽  
Guadalupe Gutierrez ◽  
Quy H. Nguyen ◽  
Darisha Jhutty ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Single Cell ◽  
Mammary Epithelial Cell ◽  
Chromatin Accessibility ◽  
Mammary Epithelial ◽  
Cell Identity ◽  
Accessibility Analysis

scholarly journals Integrated Single-Cell Transcriptomics and Chromatin Accessibility Analysis Reveals Regulators of Mammary Epithelial Cell Identity

Cell Reports ◽  
2020 ◽  
Vol 33 (3) ◽  
pp. 108273
Author(s):  
Nicholas Pervolarakis ◽  
Quy H. Nguyen ◽  
Justice Williams ◽  
Yanwen Gong ◽  
Guadalupe Gutierrez ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Single Cell ◽  
Mammary Epithelial Cell ◽  
Chromatin Accessibility ◽  
Mammary Epithelial ◽  
Cell Identity ◽  
Accessibility Analysis

scholarly journals Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity

2019 ◽  
Author(s):  
Nicholas Pervolarakis ◽  
Quy H. Nguyen ◽  
Guadalupe Gutierrez ◽  
Peng Sun ◽  
Darisha Jhutty ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Single Cell ◽  
Mammary Epithelial Cell ◽  
Cell Types ◽  
Regulatory Elements ◽  
Chromatin Accessibility ◽  
Mammary Epithelial ◽  
Secretory Cells ◽  
Basal Cells ◽  
Accessibility Analysis

ABSTRACTThe mammary epithelial cell (MEC) system is a bi-layered ductal epithelial network consisting of luminal and basal cells, which is maintained by a lineage of stem and progenitor cell populations. Here, we used integrated single-cell transcriptomics and chromatin accessibility analysis to reconstruct the cell types of the mouse MEC system and their underlying gene regulatory features in an unbiased manner. We define previously unrealized differentiation states within the secretory type of luminal cells, which can be divided into distinct clusters of progenitor and mature secretory cells. By integrating single-cell transcriptomics and chromatin accessibility landscapes, we identified novel cis- and trans-regulatory elements that are differentially activated in the specific epithelial cell types and our newly defined luminal differentiation states. Our work provides an unprecedented resource to reveal novel cis/trans regulatory elements associated with MEC identity and differentiation that will serve as a valuable reference to determine how the chromatin accessibility landscape changes during breast cancer.

scholarly journals Inhibition of the RUNX1-CBFβ transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking

Oncotarget ◽  
2020 ◽  
Vol 11 (26) ◽  
pp. 2512-2530
Author(s):  
Joshua T. Rose ◽  
Eliana Moskovitz ◽  
Joseph R. Boyd ◽  
Jonathan A. Gordon ◽  
Nicole A. Bouffard ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Epithelial Cell ◽  
Mammary Epithelial Cell ◽  
Mammary Epithelial ◽  
Cell Identity ◽  
Gene Bookmarking ◽  
Transcription Factor Complex

Role of p53 Mammary Epithelial Cell Senescence

2005 ◽  
Author(s):  
Goberdhan P. Dimri
Keyword(s):  
Epithelial Cell ◽  
Mammary Epithelial Cell ◽  
Cell Senescence ◽  
Mammary Epithelial
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