Environmental Exposure to Perfluoroalkyl Substances in Early Pregnancy, Maternal Glucose Homeostasis and the Risk of Gestational Diabetes: A Prospective Cohort Study

Abstract Background: Preterm birth (PTB, < 37 completed weeks’ gestation) is one of the global public health concerns. Epidemiologic evidence on the potential impact of perfluoroalkyl substances (PFAS) on PTB is still limited and inconsistent. We aimed to investigate the associations between prenatal PFAS exposure and PTB among singleton live births.Methods: We studied 2849 mother-infant pairs in the Shanghai Birth Cohort (SBC) from 2013 to 2016. Ten PFAS in maternal plasma in early pregnancy (gestational age, median (interquartile range): 15 (13 - 16) weeks) were measured. Primary outcomes were duration of gestation, PTB, spontaneous PTB and clinically indicated PTB. A linear regression model was used to assess the associations between ln-transformed PFAS and duration of gestation (in weeks). Logistic regression models were applied to estimate the relative risks of these outcomes. Results: The incidence of overall PTB was 4.8% (95% confidence limit: 4.0% - 5.6%, n = 136) in this study population. In the linear regression analyses, PFAS were not associated with the duration of gestation after controlling for potential confounders. In the multiple logistic models, no significant associations were observed between PFAS and overall PTB, spontaneous or indicated PTB. Conclusion: Our prospective cohort study shows that maternal plasma PFAS concentrations in early pregnancy was not associated with gestational length, overall PTB, spontaneous or indicated PTB.

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Perfluoroalkyl Substances Exposure in Early Pregnancy and Preterm Birth in Singleton Pregnancies: A Prospective Cohort Study

10.21203/rs.2.17401/v1 ◽

2019 ◽

Author(s):

Xiaona Huo ◽

Lin Zhang ◽

Rong Huang ◽

Liping Feng ◽

Weiye Wang ◽

...

Keyword(s):

Logistic Regression ◽

Cohort Study ◽

Preterm Birth ◽

Regression Model ◽

Prospective Cohort Study ◽

Early Pregnancy ◽

Prospective Cohort ◽

Maternal Plasma ◽

Perfluoroalkyl Substances ◽

Duration Of Gestation

Abstract Background: Preterm birth (PTB, < 37 completed weeks’ gestation) is one of the global public health concerns. Epidemiologic evidence on the potential impact of perfluoroalkyl substances (PFAS) on PTB is still limited and inconsistent. We aimed to investigate the associations between prenatal PFAS exposure and PTB among singleton live births. Methods: We studied 2849 mother-infant pairs in the Shanghai Birth Cohort (SBC) from 2013 to 2016. Ten PFAS in maternal plasma in early pregnancy were measured. Primary outcomes were duration of gestation, PTB, spontaneous PTB and clinically indicated PTB. A linear regression model was used to assess the associations between ln-transformed PFAS and duration of gestation (weeks). A logistic regression model was applied to estimate the risks of these outcomes within a ln-transformed continuous PFAS concentrations and across non-transformed quartiles of PFAS concentrations. A Cox proportional hazards model was also used to examine the associations by treating PFAS as continuous ln-transformed variables. Results: The incidence of overall PTB was 4.8% (95% confidence limit: 4.0% - 5.6%) in this study population. In the linear logistic regression analyses, PFAS were not associated with duration of gestation after controlling for potential confounders. In the multiple logistic model and Cox model analyses, no significant associations were observed between PFAS and overall PTB, spontaneous PTB or indicated PTB. Conclusion: Our prospective cohort study shows that maternal plasma PFAS concentrations in early pregnancy was not associated with gestational length, overall PTB, spontaneous PTB or indicated PTB.

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