What Affects Factor Loading Uncertainty and Expected Returns? The Role of Accounting Quality

2021 ◽  
Author(s):  
Bin Miao ◽  
Chenkai Ni ◽  
Charles Shi

2012 ◽  
Vol 26 (1) ◽  
pp. 158-207 ◽  
Author(s):  
Christopher S. Armstrong ◽  
Snehal Banerjee ◽  
Carlos Corona


Author(s):  
Chris S. Armstrong ◽  
Snehal Banerjee ◽  
Carlos Corona






2020 ◽  
Vol 117 (21) ◽  
pp. 11409-11420 ◽  
Author(s):  
Shrabasti Roychoudhury ◽  
Suravi Pramanik ◽  
Hannah L. Harris ◽  
Mason Tarpley ◽  
Aniruddha Sarkar ◽  
...  

Formation of G-quadruplex (G4) DNA structures in key regulatory regions in the genome has emerged as a secondary structure-based epigenetic mechanism for regulating multiple biological processes including transcription, replication, and telomere maintenance. G4 formation (folding), stabilization, and unfolding must be regulated to coordinate G4-mediated biological functions; however, how cells regulate the spatiotemporal formation of G4 structures in the genome is largely unknown. Here, we demonstrate that endogenous oxidized guanine bases in G4 sequences and the subsequent activation of the base excision repair (BER) pathway drive the spatiotemporal formation of G4 structures in the genome. Genome-wide mapping of occurrence of Apurinic/apyrimidinic (AP) site damage, binding of BER proteins, and G4 structures revealed that oxidized base-derived AP site damage and binding of OGG1 and APE1 are predominant in G4 sequences. Loss of APE1 abrogated G4 structure formation in cells, which suggests an essential role of APE1 in regulating the formation of G4 structures in the genome. Binding of APE1 to G4 sequences promotes G4 folding, and acetylation of APE1, which enhances its residence time, stabilizes G4 structures in cells. APE1 subsequently facilitates transcription factor loading to the promoter, providing mechanistic insight into the role of APE1 in G4-mediated gene expression. Our study unravels a role of endogenous oxidized DNA bases and APE1 in controlling the formation of higher-order DNA secondary structures to regulate transcription beyond its well-established role in safeguarding the genomic integrity.



1995 ◽  
Vol 55 (1) ◽  
pp. 58-97 ◽  
Author(s):  
B. Zorina Khan

Economic development depends on the establishment of appropriate institutions, such as a patent system that defends property rights in inventions. Skeptics argue that patents in early America were unenforceable because judges arbitrarily ruled against patentees. I examine 795 patent cases to assess the role of the courts and find that judges protected patent rights because they believed that inventors were motivated by expected returns. Although changes occurred in the 1850s, the courts consistently upheld the view that the patent system fostered economic growth. If inventive activity indeed responded to material incentives, this finding implies that the legal system stimulated technical change by reinforcing the effectiveness of the patent system.The laws of the United States are extremely favorable to the division of property.—Alexis de Tocqueville, Democracy in America



Author(s):  
Verrnica de FFtima Santana ◽  
Alex Augusto Timm Rathke ◽  
Isabel Lourenno ◽  
Fllvia ZZboli Dalmmcio




Author(s):  
Juan M. Garcca Lara ◽  
Beatriz Garcia Osma ◽  
Araceli Mora ◽  
Mariano P. Scapin


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