Noncanonical TGFβ Signaling Promotes Specialized Neuroretina Tip-Cell Sprouting and Blood-Retina Barrier Formation

2021 ◽  
Author(s):  
Georgia Zarkada ◽  
Joel P. Howard ◽  
Xue Xiao ◽  
Hyojin Park ◽  
Mathilde Bizou ◽  
...  
Keyword(s):  
Tgfβ Signaling ◽  
Tip Cell ◽  
Barrier Formation

173: Lipid Rafts are Negative Regulators of TGFβ Signaling in Ureteral Smooth Muscle Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 46-46
Author(s):  
Carlos R. Estrada ◽  
Theodora Danciu ◽  
Maximilian Stehr ◽  
Joseph Khoury ◽  
Keith R. Solomon ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Lipid Rafts ◽  
Muscle Cells ◽  
Negative Regulators ◽  
Tgfβ Signaling

Endothelial Tip Cell Invasive Behaviour During Sprouting Angiogenesis is Controlled by Myosin IIA-Dependent Inhibition of Arp2/3 Activity

2020 ◽  
Author(s):  
Ana M. Figueiredo ◽  
Pedro Barbacena ◽  
Rita Ferreira ◽  
Ana Russo ◽  
Silvia Vaccaro ◽  
...  
Keyword(s):  
Tip Cell ◽  
Sprouting Angiogenesis ◽  
Dependent Inhibition ◽  
Myosin Iia

TGFβ Signaling in Head and Neck Cancer Development and Metastases

2009 ◽  
pp. 163-183
Author(s):  
Stephen P. Malkoski ◽  
Jessyka G. Lighthall ◽  
Xiao-Jing Wang
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Development ◽  
Tgfβ Signaling

scholarly journals Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 336
Author(s):  
Roberta Melchionna ◽  
Paola Trono ◽  
Annalisa Tocci ◽  
Paola Nisticò
Keyword(s):  
Cancer Progression ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Tissue Homeostasis ◽  
Actin Dynamics ◽  
Human Tissues ◽  
Cellular Functions ◽  
Tgfβ Signaling ◽  
Physical Mechanisms ◽  
And Function

Human tissues, to maintain their architecture and function, respond to injuries by activating intricate biochemical and physical mechanisms that regulates intercellular communication crucial in maintaining tissue homeostasis. Coordination of the communication occurs through the activity of different actin cytoskeletal regulators, physically connected to extracellular matrix through integrins, generating a platform of biochemical and biomechanical signaling that is deregulated in cancer. Among the major pathways, a controller of cellular functions is the cytokine transforming growth factor β (TGFβ), which remains a complex and central signaling network still to be interpreted and explained in cancer progression. Here, we discuss the link between actin dynamics and TGFβ signaling with the aim of exploring their aberrant interaction in cancer.

scholarly journals An in vitro model of avian skin reveals evolutionarily conserved transcriptional regulation of epidermal barrier formation

2021 ◽  
Author(s):  
Julia Lachner ◽  
Sophia Derdak ◽  
Veronika Mlitz ◽  
Tanja Wagner ◽  
Karin Brigit Holthaus ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
In Vitro Model ◽  
Epidermal Barrier ◽  
Barrier Formation ◽  
Evolutionarily Conserved ◽  
Vitro Model
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