scholarly journals Consistent Local Spectrum (Lcm) Inference for Predictive Return Regressions

2021 ◽  
Author(s):  
Torben G. Andersen ◽  
Rasmus Varneskov
Keyword(s):  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
P. Loza ◽  
A. Irmejs ◽  
Z. Daneberga ◽  
E. Miklasevics ◽  
E. Berga-Svitina ◽  
...  

Abstract Background Several recent studies in the Baltic region have found extended spectrum of pathogenic variants (PV) of the BRCA1/2 genes. The aim of current study is to analyze the spectrum of the BRCA1/2 PV in population of Latvia and to compare common PV between populations of the Baltic region. Methods We present a cohort of 9543 unrelated individuals including ones with cancer and unaffected individuals from population of Latvia, who were tested for three most common BRCA1 founder PV. In second line testing, 164 founder negative high-risk individuals were tested for PV of the BRCA1/2 using next generation sequencing (NGS). Local spectrum of the BRCA1/2 PV was compared with the Baltic region by performing a literature review. Results Founder PV c.5266dupC, c.4035delA or c.181 T > G was detected in 369/9543 (3.9%) cases. Other BRCA1/2 PV were found in 44/164 (26.8%) of NGS cases. Four recurrent BRCA1 variants c.5117G > A (p.Gly1706Glu), c.4675G > A (p.Glu1559Lys), c.5503C > T (p.Arg1835*) and c.1961delA (p.Lys654fs) were detected in 18/44 (41.0%), 5/44 (11.4%), 2/44 (4.5%) and 2/44 (4.5%) cases respectively. Additionally, 11 BRCA1 PV and six BRCA2 PV were each found in single family. Conclusions By combining three studies by our group of the same cohort in Latvia, frequency of the BRCA1/2 PV for unselected breast and ovarian cancer cases is 241/5060 (4.8%) and 162/1067 (15.2%) respectively. The frequency of three “historical” founder PV is up to 87.0% (369/424). Other non-founder PV contribute to at least 13.0% (55/424) and this proportion probably will rise by increasing numbers of the BRCA1/2 sequencing. In relative numbers, c.5117G > A is currently the third most frequent PV of the BRCA1 in population of Latvia, overcoming previously known third most common founder variant c.181 T > G. In addition to three BRCA1 founder PV, a total of five recurrent BRCA1 and two recurrent BRCA2 PV have been reported in population of Latvia so far. Many of the BRCA1/2 PV reported in Latvia are shared among other populations of the Baltic region.


2017 ◽  
Vol 61 ◽  
pp. 208-222 ◽  
Author(s):  
Haroun Errachid Adardour ◽  
Maghnia Meliani ◽  
Mohamed Hicham Hachemi

2017 ◽  
Vol 60 (4) ◽  
pp. 791-806 ◽  
Author(s):  
Chunlan Jiang

AbstractA C*-algebra Ahas the ideal property if any ideal I of Ais generated as a closed two-sided ideal by the projections inside the ideal. Suppose that the limit C*-algebra A of inductive limit of direct sums of matrix algebras over spaces with uniformly bounded dimension has the ideal property. In this paper we will prove that A can be written as an inductive limit of certain very special subhomogeneous algebras, namely, direct sum of dimension-drop interval algebras and matrix algebras over 2-dimensional spaces with torsion H2 groups.


2019 ◽  
Vol 12 (8) ◽  
pp. 082010 ◽  
Author(s):  
Cong Shao ◽  
Guolu Yin ◽  
Lei Lv ◽  
Min Liu ◽  
Iroegbu Paul Ikechukwu ◽  
...  

Author(s):  
Z. Cherneva ◽  
C. Guedes Soares

The main goal of the present paper is to study the differences of the descriptors of the wave groups in the nonlinear case in comparison with the same parameters for a Gaussian process. The data analyzed are from a deep water basin of Marintek. They consist of sequence of five identical independent experimental runs of unidirectional waves measured at ten fixed points situated in different distances from the wave maker. Each series contain about 1800 waves. Thus the statistics collected from a given gauge comprise about 9000 waves combined in a number of wave groups. Because the series describe a process significantly different from the Gaussian one, an upper and lower envelopes are introduced as lines which connect the peaks of the crests and the lower points of the troughs respectively. Spline functions are applied to calculate these envelopes. Then, the mean high run and mean group length are estimated for different levels, their ensemble average over five experimental runs is found for every gauge and is compared with the results of the theory of Gaussian process. It is found that the values of the mean time intervals of the groups correlate with coefficient of kurtosis of the process. It is determined also that mean group length is shorter and the mean high run is larger for the nonlinear wave groups in comparison with the Gaussian wave groups. The modification of wave groups in space and time is investigated in the work as well. Wigner time-frequency spectrum with Choi-Williams kernel is applied to describe the process of entire modulation and demodulation of the groups. It is found that before formation of the high wave a wave down-shifting takes place. At this stage the local spectrum is relatively narrow and the group shrinks continuously. Close to the focus the time-frequency spectrum is very wide and the group has a triangle form. Further the high wave breaks and the wave group acquires the form of “three sisters.” The transform of the group continues by its disintegration, the local spectrum stands narrow and an up-shifting is observed.


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