Twinship and Childhood Atopic Disease: Understanding Early-Life Factors Among Discordant Twins in Ontario, Canada

2021 ◽  
Author(s):  
Kimball Zhang ◽  
Jingqin Zhu ◽  
Emilie Terebessy ◽  
Ivy Fong ◽  
Teresa To
Keyword(s):  
Early Life ◽  
Atopic Disease ◽  
Early Life Factors ◽  
Discordant Twins ◽  
Disease Understanding

Early life factors related to clinical manifestations of atopic disease but not to skin-prick test positivity in young children

2002 ◽  
Vol 13 (2) ◽  
pp. 105-112 ◽  
Author(s):  
Maria-Antonietta Stazi ◽  
Francesca Sampogna ◽  
GIuseppe Montagano ◽  
Michele E. Grandolfo ◽  
Marie-France Couilliot ◽  
...  
Keyword(s):  
Young Children ◽  
Skin Prick Test ◽  
Early Life ◽  
Clinical Manifestations ◽  
Atopic Disease ◽  
Prick Test ◽  
Early Life Factors

Influence of Early Life Factors on Jail Detention of African Americans As Adults

2014 ◽  
Author(s):  
Sarah J. Spann ◽  
Negar Fani ◽  
Bekh Bradley ◽  
Kerry Ressler
Keyword(s):  
African Americans ◽  
Early Life ◽  
Early Life Factors

Maternal age, birth order and other early-life factors: a family-level approach to exploring exceptional survival

2014 ◽  
Vol Volume 11 ◽  
pp. 267-294 ◽  
Author(s):  
Valérie Jarry ◽  
Alain Gagnon ◽  
Robert Bourbeau
Keyword(s):  
Birth Order ◽  
Early Life ◽  
Maternal Age ◽  
Family Level ◽  
Early Life Factors

scholarly journals The impact of early life factors on cognitive function in old age: The Hordaland Health Study (HUSK)

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Jens Christoffer Skogen ◽  
Simon Øverland ◽  
A David Smith ◽  
Arnstein Mykletun ◽  
Robert Stewart
Keyword(s):  
Cognitive Function ◽  
Old Age ◽  
Early Life ◽  
Health Study ◽  
Early Life Factors ◽  
The Impact

scholarly journals Early life factors and dental caries in 5-year-old children in China

2017 ◽  
Vol 64 ◽  
pp. 73-79 ◽  
Author(s):  
Xiangyu Sun ◽  
Eduardo Bernabé ◽  
Xuenan Liu ◽  
Jennifer E. Gallagher ◽  
Shuguo Zheng
Keyword(s):  
Dental Caries ◽  
Early Life ◽  
Early Life Factors

Association between early-life factors and risk of child-onset Crohnʼs disease among victorian children born 1983–1998: A birth cohort study

2009 ◽  
Vol 15 (6) ◽  
pp. 858-866 ◽  
Author(s):  
Anne-Louise Ponsonby ◽  
Anthony G. Catto-Smith ◽  
Angela Pezic ◽  
Sandy Dupuis ◽  
Jane Halliday ◽  
...  
Keyword(s):  
Cohort Study ◽  
Birth Cohort ◽  
Early Life ◽  
Birth Cohort Study ◽  
Early Life Factors

scholarly journals Association of intrauterine and early life factors with uterine leiomyomata in black women

2012 ◽  
Vol 22 (12) ◽  
pp. 847-854 ◽  
Author(s):  
Lauren A. Wise ◽  
Rose G. Radin ◽  
Julie R. Palmer ◽  
Lynn Rosenberg
Keyword(s):  
Black Women ◽  
Early Life ◽  
Uterine Leiomyomata ◽  
Early Life Factors

Early Life Factors for Overweight Risk Among Infants of Hispanic Immigrant Mothers

2019 ◽  
Vol 33 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Kathleen F. Gaffney ◽  
Deborah A. Kermer ◽  
Panagiota Kitsantas ◽  
Albert V. Brito ◽  
Katya M. Ramos ◽  
...  
Keyword(s):  
Early Life ◽  
Immigrant Mothers ◽  
Early Life Factors

Early life factors as predictors of age-associated deficit accumulation across 17 years from midlife into old age

2022 ◽  
Author(s):  
Markus J Haapanen ◽  
Juulia Jylhävä ◽  
Lauri Kortelainen ◽  
Tuija M Mikkola ◽  
Minna Salonen ◽  
...  
Keyword(s):  
Old Age ◽  
Early Life ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Frailty Index ◽  
Rate Of Change ◽  
Birth Cohort Study ◽  
Maternal Body Mass Index ◽  
Early Life Factors ◽  
Early Life Exposures

Abstract Background Early life exposures have been associated with the risk of frailty in old age. We investigated whether early life exposures predict the level and rate of change in a frailty index (FI) from midlife into old age. Methods A linear mixed model analysis was performed using data from three measurement occasions over 17 years in participants from the Helsinki Birth Cohort Study (n=2000) aged 57-84 years. A 41-item FI was calculated on each occasion. Information on birth size, maternal body mass index (BMI), growth in infancy and childhood, childhood socioeconomic status (SES), and early life stress (wartime separation from both parents), was obtained from registers and healthcare records. Results At age 57 years the mean FI level was 0.186 and the FI levels increased by 0.34 percent/year from midlife into old age. Larger body size at birth associated with a slower increase in FI levels from midlife into old age. Per 1kg greater birth weight the increase in FI levels per year was -0.087 percentage points slower (95% CI=-0.163, -0.011; p=0.026). Higher maternal BMI was associated with a higher offspring FI level in midlife and a slower increase in FI levels into old age. Larger size, faster growth from infancy to childhood, and low SES in childhood were all associated with a lower FI level in midlife but not with its rate of change. Conclusions Early life factors seem to contribute to disparities in frailty from midlife into old age. Early life factors may identify groups that could benefit from frailty prevention, optimally initiated early in life.

FC 059EARLY LIFE FACTORS AND ADULT KIDNEY FUNCTION ESTIMATED BY CYSTATIN C AND CREATININE GLOMERULAR FILTRATION RATE EQUATIONS AND ALBUMINURIA: A SWEDISH COHORT STUDY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Agne Laucyte-Cibulskiene ◽  
Shantanu Sharma ◽  
Peter M Nilsson ◽  
Anders Christensson
Keyword(s):  
Regression Analysis ◽  
Birth Weight ◽  
Kidney Function ◽  
Cystatin C ◽  
Early Life ◽  
Postnatal Growth ◽  
Lower Birth Weight ◽  
Adult Kidney ◽  
Early Life Factors

Abstract Background and Aims Renal functional capacity is influenced by factors acting early in life, such as intrauterine environment, maturity, birth weight, length at birth, placental weight etc. Early life factors are responsible for the number of nephrons a person starts life with, and the consequence of a low nephron number is earlier kidney ageing and chronic kidney disease (CKD). Notably, most reports addressing early life factors in the context of adult kidney function use creatinine-based eGFR equations and/or albuminuria and lack longer follow-up (<30 years). Therefore, we aimed to identify early life factors associated with kidney function, determined by different creatinine and cystatin C equations and urinary albumin-to-creatinine ratio (UACR), more than 40 years later. Method 94 women and 494 men, born 1923-50, who participated in The Malmo Diet and Cancer (MDC) study were analyzed. Perinatal data records including birth weight (BW), birth length, head circumference, gestational age, placenta weight (PW) and mother related risk factors were collected from hospital and regional state archives. After a follow-up of 46 to 67 years study subjects underwent physical examination, blood pressure measurements and estimation of glomerular filtration rate (eGFR) using 4 different equations: Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2012 creatinine and cystatin C formula (CKD-EPI_creatinine, CKD-EPI_cystatin C), cystatin C eGFR equation based on Caucasian, Asian, pediatric, and adult cohorts (CAPA), the Lund-Malmö revised creatinine based eGFR equation (LM_rev). Urinary albumin-to-creatinine ratio (UACR) was measured in morning urine samples, albuminuria was defined as UACR ⩾3 mg/mmol. Birth weight z-scores (gender specific BWz and combined BWz) acquired by using the equation as reported by Marsal et al.(1996). Four growth mismatch phenotypes defined by combining low or high BW z-score (lowBWz or hiBWz respectively) with lower or higher body mass index at 20 years of age (lowBMI20 ir hiBMI20 respectively). Results Linear regression analysis of early life factors indicated that in females birth weight was positively associated with kidney function measured by both CAPA and CKD-EPI_cystatin C. In the whole population, birth weight adjusted for gestational age and sex, together with prematurity were independently associated to CKD-EPI_cystatin C, while BW/PW ratio was related to LM_rev. Logistic regression analysis showed that only gender specific BWz and combined BWz shared the same odds ratios for age and pulse pressure adjusted albuminuria in males (OR 0,75 (95%CI [0,58; 0,96]). While analyzing postnatal growth mismatch we found that females with hiBWz/lowBMI20 phenotype had significantly worse kidney function acquired by both cystatin C equations compared to those with lowBWz/lowBMI20 phenotype (p=0.044 for CAPA, p=0.040 for CKD-EPI_cystatin C). The logistic regression analysis revealed that hiBWz/hiBMI20 phenotype was related to lower risk of age and pulse pressure adjusted albuminuria (OR 0,35 (95%CI[0,12;0,93]) Conclusion Here we report that lower birth weight in females is associated with worse kidney function determined by cystatin C eGFR equations, while in males lower birth weight z-score is a risk factor for albuminuria in adulthood. Postnatal growth catch-up is not related to worse kidney function. We identified the protective phenotype (hiBWz/hiBMI20) for albuminuria in males and the unfavorable phenotype (hiBWz/lowBMI20) for kidney function in females. This suggests that lower birth weight and postnatal growth curve have a potential sex specific effect to kidney function and development of CKD in middle-aged Swedish subjects. Further studies are warranted to address early life factor prognostic accuracy in kidney function and outcomes prediction later in the lifetime.

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