The article deals with the issues of sustainable development of the Middle Volga region. The study analyzed both indicators of socio-economic development and environmental quality indicators of five regions — the Republic of Tatarstan, the Republic of Chuvashia ( Chuvash Republic), Penza, Ulyanovsk and Samara regions — and proposed mechanisms for the transition to sustainable development for these regions. The article outlines a set of measures to achieve sustainable development of the cluster of regions of the Middle Volga region, including the integration of sustainable development goals in regional and municipal development programs, will solve current socio-economic problems, as well as ensure sustainable growth of the region, based on a balance between economic growth, investment in the quality of life of the regions of the Middle Volga and respect for the environment and consumption of natural resources.