scholarly journals A Review on Various Analytical Methodologies for Etoricoxib

2021 ◽  
Vol 11 (1) ◽  
pp. 61-70
Author(s):  
Malesh Prajapati ◽  
Dilip Bhagwan Yamgar ◽  
Mayur Narayan Desale ◽  
Bharti Fegade
Keyword(s):  
Analytical Method ◽  
Method Development ◽  
Biological Fluids ◽  
Regulatory Requirements ◽  
Tissue Extracts ◽  
Critical Process Parameters ◽  
Quantitative Results ◽  
Analytical Tools ◽  
Critical Process ◽  
Dose Form

Etoricoxib belongs to the class of highly selective COX-2 inhibitor NSAIDs. It is mostly used for the treatment of pain, arthritic conditions including rheumatoid arthritis and osteoarthritis. The current study focuses primarily on analytical and bioanalytical method development methodologies, as well as numerous methods established for the estimation of etoricoxib, whether in pharmaceutical dose form or in bulk. Analytical procedures are critical for determining compositions, as they allow us to obtain both qualitative and quantitative results utilising advanced analytical tools. The analytical method for Etoricoxib may be chromatographic, electrochemical, spectral or hyphenated.  These methods aid in the comprehension of critical process parameters as well as the minimization of their impact on precision and accuracy. Analytical method development is required to sustain high commercial product quality standards and to meet regulatory requirements. Following the reference, regulatory organisations in several nations have established standards and procedures for providing approval, authentication, and registration. Bioanalytical methods are designed to quantify the concentration of drug, metabolite, or typical biomarkers from various biological fluids including serum, urine, saliva and tissue extracts.

scholarly journals METHODS OF METOPROLOL ANALYSIS IN DRUGS AND BIOLOGICAL FLUIDS: REVIEW AND SUGGESTIONS

2020 ◽  
Vol 5 (2) ◽  
pp. 88-97
Author(s):  
M. M. Horyn ◽  
L. S. Logoyda
Keyword(s):  
Analytical Method ◽  
High Speed ◽  
High Performance ◽  
Method Development ◽  
High Efficiency ◽  
Biological Fluids ◽  
Dosage Forms ◽  
Pharmaceutical Chemistry ◽  
Components Separation ◽  
Analysis Methods

Background. Analytical method is increasingly implemented into fundamental pharmaceutical chemistry and analysis, considering their high sensitivity, accuracy, specificity and expressiveness. Objective. Metoprolol’s analytical method development was the research goal. Methods. The sources were world recognized journals (1990-2019) and key words used as filter were “metoprolol”, “spectrophotometry” “high-performance liquid chromatography, HPLC”, “quantitative analysis”, “validation”. Results. Chromatographic methods of analysis have the highest specificity and objectivity and allow qualitative and quantitative determination of Active Pharmaceutic Ingredient (API) in combined dosage forms and biological fluids without prior components separation. The main disadvantage of the described API analysis methods is long terms from the beginning of chromatography to API release and specific solvents used as the mobile phase in HPLC. New methods development and selection such chromatographic conditions that provide high speed and high efficiency at lower pressure of the system are essential. Also, the reduction of analysis time is achieved by simplifying the conditions for sample preparation. Conclusions. Analysts are constantly working on developing new analysis methods and their optimization in order to save time and consumables, which also ensures the efficiency of the developed method. There is no monograph on the substance or dosage forms of metoprolol in SPhU. Therefore, some of the developed methods should be suggested for the SPhU monograph, which is important for ensuring pharmacopoeial quality control of medicines in Ukraine.

scholarly journals A review on bioanalytical method development and pre-method validation concepts using SPE and LLE process by LC-MS/MS method

2021 ◽  
Vol 12 (2) ◽  
pp. 1353-1359
Author(s):  
Arun Kumar V ◽  
Vijey Aanandhi M ◽  
Gandhimathi R ◽  
Sumithra M
Keyword(s):  
Method Validation ◽  
Analytical Method ◽  
Method Development ◽  
Biological Fluids ◽  
Internal Standard ◽  
Pharmacokinetic Studies ◽  
Detection Techniques ◽  
Extraction Procedures ◽  
Highly Sensitive ◽  
Pharmacokinetic Properties

The review article provides guidance for the development of a Bio-Analytical Method intended for the estimation of drugs in biological fluids. The development of a suitable analytical method for the identification, isolation and quantification of different drugs and or their metabolites from biological fluids is an essential and challenging component of pharmacokinetic studies. The uses of detection techniques that are highly sensitive and specific for the quantification of drugs and or metabolites in biological fluids are preferred. To collect the information on physiochemical, pharmacokinetic, chromatographic and extraction procedures of the drug/Metabolites from available sources, e.g. Medline, Journals, Analytical abstract, Physician Desk Reference, Library etc. Summarize the physiochemical, pharmacokinetic properties, chromatographic and extraction procedures. Select the equipment according to the availability and sensitivity. Select the initial chromatographic conditions and also identify the extraction. The selection of Internal standard should be similar to the analyte. Prepare the required solutions and stock dilutions at the required concentration. Tune the instrument with suitable solutions and optimize parameters for Q1/Q3 ions. Condition the system and column with the selected mobile phase. Perform pre-method validation experiments. Select the best weighing factors for the standards. Compile all the chromatograms and raw data and archive since the development of a Bio-Analytical method for a given drug is so essential to start with, this guidance for approaching and conclude for a suitable method that later can be validated. It is important to note that this is intended to identify minimal criteria for producing consistent and comparable data. This procedure is applicable to the methods that are to be developed for the estimation of drugs and metabolites from biological fluids using any chromatographic devices in the Bio- Analytical Department.

scholarly journals Designing ultra-small nanostructured lipid carriers: critical process parameters

2020 ◽  
Author(s):  
Maria Mendes ◽  
João Basso ◽  
João Sousa ◽  
Alberto Pais ◽  
Carla Vitorino
Keyword(s):  
Process Parameters ◽  
Nanostructured Lipid Carriers ◽  
Critical Process Parameters ◽  
Critical Process

Green analytical method for the determination of sofosbuvir, ledipasvir, ribavirin and complex silymarin flavonoids simultaneously in biological fluids

2021 ◽  
Vol 164 ◽  
pp. 105964
Author(s):  
Amira F. El-Yazbi ◽  
Yasmine Khalifa ◽  
Mohammed A.W. Elkhatib ◽  
Ahmed F. El-Yazbi
Keyword(s):  
Analytical Method ◽  
Biological Fluids

scholarly journals An In-Process Intervention to Mitigate the Effect of Built-Up Edges in Micromilling

2017 ◽  
Vol 5 (4) ◽  
Author(s):  
Robert G. Altman ◽  
James F. Nowak ◽  
Johnson Samuel
Keyword(s):  
Machining Process ◽  
Burr Formation ◽  
Tool Runout ◽  
Part Geometry ◽  
Intervention Technique ◽  
Mechanical Removal ◽  
Working Volume ◽  
G Code ◽  
Critical Process Parameters ◽  
Critical Process

This paper is focused on developing an in-process intervention technique that mitigates the effect of built-up edges (BUEs) during micromilling of aluminum. The technique relies on the intermittent removal of the BUEs formed during the machining process. This is achieved using a three-stage intervention that consists first of the mechanical removal of mesoscale BUEs, followed by an abrasive slurry treatment to remove the microscale BUEs. Finally, the tool is cleaned using a nonwoven fibrous mat to remove the slurry debris. An on-machine implementation of this intervention technique is demonstrated, followed by a study of its influence on key micromachining outcomes such as tool wear, cutting forces, part geometry, and burr formation. In general, all relevant machining measures are found to improve significantly with the intervention. The key attributes of this intervention that makes it viable for micromachining processes include the following: (i) an experimental setup that can be implemented within the working volume of the microscale machine tool; (ii) no removal of the tool from the spindle, which ensures that the intervention does not change critical process parameters such as tool runout and offset values; and (iii) implementation in the form of canned G-code subroutines dispersed within the regular micromachining operation.

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